The level of vitamin D in the serum correlates with fatty degeneration of the muscles of the rotator cuff

Oh, Joo Han; Kim, S. H.; Kim, J. H.; Shin, Y. H.; Yoon, Jong Pil; Oh, Chung Hee

doi:10.1302/0301-620x.91b12.22481

Cited by 82 publications

(82 citation statements)

References 42 publications

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“…21 In addition, two studies reported an association between low 25(OH)D levels and fatty degeneration of thigh and rotator cuff muscles. 23,24 This potential effect of vitamin D on muscle biology is likely to affect creatinine production. Indeed, an increase in creatininemia due to enhanced creatinine production without variation in GFR has been reported under calcitriol therapy.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Outcomes After Renal Transplantation

Bienaimé

Girard

Anglicheau

et al. 2013

Journal of the American Society of Nephrology

101

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Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period, but the association between vitamin D status with renal outcomes is not well described in this population. Here, we studied a prospective cohort of 634 kidney recipients who underwent transplantation at a single institution between January 2005 and June 2010. In this cohort, low 25-hydroxyvitamin D concentrations 3 months after transplantation did not predict early death or graft loss but were independently associated with lower measured GFR at 12 months (P=0.001) and higher risk for interstitial fibrosis and tubular atrophy (P=0.01). In contrast, levels of calcium, phosphorus, calcitriol, parathyroid hormone, or fibroblast growth factor-23 were not consistently associated with any of the studied outcomes. In conclusion, low 25-hydroxyvitamin D concentration measured 3 months after transplantation is an independent risk factor for interstitial fibrosis progression and is associated with a lower GFR 1 year after transplantation. 24: 831-841, 201324: 831-841, . doi: 10.1681 Kidney transplantation is the preferred treatment for the increasing number of patients with ESRD. Transplantation allows patients to avoid the heavy constraints associated with dialysis therapy and is associated with a lower mortality and morbidity than is hemodialysis. 1 Evolution of GFR in transplant recipients appears to be imprinted at an early stage after the surgery. Indeed, the estimated GFR (eGFR) reached 1 year after transplantation is critically associated with allograft outcome. 2,3 This observation prompts research on modifiable factors affecting GFR in the first year after transplantation. J Am Soc NephrolVitamin D is a critical hormone controlling mineral homeostasis. It promotes phosphate and calcium absorption by the gut and increases calcium reabsorption by the renal distal tubule, thereby providing the positive calcium and phosphorus flux required for bone mineralization.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Outcomes After Renal Transplantation

Bienaimé

Girard

Anglicheau

et al. 2013

Journal of the American Society of Nephrology

101

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“…It has also been implicated in the risk of overall mortality [26], cancer [19,21,26], diabetes [21,26], musculoskeletal disorders [16,26], hypertension [21,26], heart disease [21,26], multiple sclerosis [19], stroke [21], and even falls [4,8,20]. Recent epidemiologic data suggest a widespread deficiency of vitamin D [13,18].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Insufficiency in Patients With THA: Prevalence and Effects on Outcome

Lavernia

Villa

Iacobelli

et al. 2013

Clin Orthop Relat Res

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Background The consequences of vitamin D insufficiency in the elderly remain controversial. The prevalence and potential effects of its chronic insufficiency on quality of life and physical function in patients undergoing THA have received little attention.Question/purposes We determined (1) prevalence of preoperative vitamin D insufficiency in patients undergoing THA and (2) relationships of insufficiency to patientperceived outcomes (PPOs) and hip scores. Methods We retrospectively reviewed 62 consecutive patients who underwent 66 primary THAs. We excluded two patients with missing data and the second hip of bilateral THAs, leaving 60 patients (60 hips) for final inclusion. Based on preoperative plasma 25-hydroxyvitamin-D3 levels, patients were retrospectively assigned into a normal or insufficient group. We used two different thresholds (20 and 30 ng/mL) to define insufficiency; groups were set twice. We compared demographics, BMI, American Society of Anesthesiologists score, Charlson Comorbidity Index; albumin, transferrin, calcium levels; and total lymphocyte count between groups. The insufficient group had a higher mean BMI with the 20-ng/mL cutoff but not with the 30-ng/mL cutoff. We compared the 20-ng/mL cutoff groups (adjusting for BMI) and the 30-ng/mL cutoff groups in terms of preoperative and postoperative Quality of Well-being Scale, SF-36, WOMAC, Harris hip, and Merle d'Aubigné-Postel scores. Mean followup was 11 months (range, 3-24 months). Results The prevalence of vitamin D insufficiency was 30% (using 20 ng/mL) and 65% (using 30 ng/mL). Preoperative and postoperative Harris hip and Merle d'Aubigné-Postel scores were lower in patients with

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“…There are substances that have an anabolic effect on muscle and could potentially counteract the formation of interfiber gaps induced by atrophy, which are known to be filled with fat. Several pharmacological substances influence the development, growth, and repair mechanisms of muscle, namely, anabolic steroids [11][12][13][14][15][16][17][18][19][20] , growth hormones [21][22][23][24] , b-2 agonists, heparan sulfate 25 , xanthine derivatives 26 , creatine 27 , and vitamin D 28 . Of all of these substances, anabolic steroids seem best suited for clinical application.…”

mentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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To our knowledge, this is the first documentation of partial prevention of important muscle alterations after retraction of the supraspinatus musculotendinous unit caused by tendon disruption. Nandrolone decanoate administration in the phase after tendon release prevented fatty infiltration of the supraspinatus muscle and reduced functional muscle impairment caused by myotendinous retraction in this rabbit rotator cuff model, but two of seven rabbits that received the drug developed infections. Background: Muscles of the rotator cuff undergo retraction, atrophy, and fatty infiltration after a chronic tear, and a rabbit

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The level of vitamin D in the serum correlates with fatty degeneration of the muscles of the rotator cuff

Cited by 82 publications

References 42 publications

Vitamin D Status and Outcomes After Renal Transplantation

Vitamin D Status and Outcomes After Renal Transplantation

Vitamin D Insufficiency in Patients With THA: Prevalence and Effects on Outcome

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

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