The level of vitamin D using the LC–MS/MS method and related factors in healthy Korean postmenopausal women

Park, Eun Jung; Lee, Hong Soo; Lee, Sang Hwa; Shim, Kyung Won; Cho, Choo-Yon; Yoo, Byung Wook

doi:10.1111/jog.13745

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…In our study, a large percentage of the population presented 25-OH-D levels below the reference values when analyzed by LC-MS/MS. Authors such as Park et al [43] analyzed 25-OH-D levels by LC-MS/MS in a population of postmenopausal women, and recorded the same high prevalence of vitamin D deficiency (82%) as in our study. This confirmed that despite use of the gold standard for the analytical determination of vitamin D, the levels of this vitamin were low.…”

Section: Discussionsupporting

confidence: 82%

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

et al. 2020

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Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D. A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44–76 years of age were included. Two randomized groups—placebo and magnesium (500 mg/day)—were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography—tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects. The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (p < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.

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Section: Discussionsupporting

confidence: 82%

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

et al. 2020

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“…We used LC-MS/MS to test serum 25(OH) D concentrations in current study. LC-MS/MS is widely accepted in clinical laboratories to differentiate between vitamin-D deficiency and sufficiency, because of its excellent analytical specificity and sensitivity [ 36 – 39 ].…”

Section: Discussionmentioning

confidence: 99%

25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children’s study (JECS)

et al. 2021

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Background The study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed the prevalence of vitamin D deficiency and insufficiency in 2-year-old Japanese children using data from a large ongoing birth cohort study. Methods Data for analysis was obtained from the Japan Environment and Children’s Study (JECS) and a Sub-Cohort Study (SCS) of JECS. We evaluated the children’s serum 25(OH) D levels by 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles, and the rates of vitamin D deficiency or insufficiency. We also presented a weighted prevalence rate for vitamin D deficiency or insufficiency among all children in JECS. Results After excluding children with missing 25(OH)D2 or 25(OH)D3 data, we analyzed 4655 remaining children, of whom 24.7% (95% CI, 23.5–26.0%) had vitamin D deficiency (< 20 ng/mL), and 51.3% (95% CI, 49.8–52.7%) were at risk of vitamin D insufficiency (20–30 ng/mL). The estimated prevalence of vitamin D deficiency and insufficiency among all children in JECS were 25.4% (95% CI, 24.1–26.7%) and 50.9% (95% CI, 49.4–52.4%). Vitamin D deficiency was found in 22.9% of boys and 26.5% of girls. Median serum 25(OH) D concentrations were lower among participants measured during winter and spring than among those measured in summer and autumn. The highest rate of vitamin D deficiency was observed in Hokkaido, the northernmost prefecture of Japan. Conclusion We analyzed data on serum 25(OH) D levels from a birth cohort study and found that vitamin D deficiency and insufficiency are very common among 2-year-old Japanese children. Sex, season, and latitude affect serum 25(OH) D concentrations.

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“…In our study, an inverse association was found between vitamin D status and fat mass. However, the weakness of this association might be explained by the presence of numerous factors which modulate fat mass, such as ethnicity, age [46], sun exposure habit, diet, and the season of the year in which the samples were taken, which can mean that even though a woman has a high fat mass, its influence on vitamin D status can lose strength [47,48]. In our study, due to the limited sample size, we could not control for some of these confounding factors.…”

Section: Discussionmentioning

confidence: 99%

Association between Body Fatness and Vitamin D3 Status in a Postmenopausal Population

et al. 2020

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Vitamin D is a micronutrient that plays a key role in phosphocalcic metabolism. The postmenopausal population presents a risk of deficiency in this vitamin due to hormonal alterations which, in the case of obesity, would be exacerbated. The objective was to assess the status of vitamin D in a postmenopausal population and determine the relationship of 25-hydroxivitamin D [25(OH)D] and its metabolites with anthropometric parameters. The study included 78 healthy postmenopausal women aged from 44 to 76. The nutrient intake assessment was carried out using the 24 h reminder (R24h). 25(OH)D was analyzed using ultra-high-performance liquid chromatography (UHPLC). A total of 80% and 68% of the women studied did not reach sufficient values of 25(OH)D and 25-hydroxivitamin D 3 [25(OH)D 3 ], respectively, which was inversely correlated with Body Mass Index (BMI) (r = −0.25, p = 0.04), hip perimeter (r = −0.26 and r = −0.24, all p < 0.05), arm circumference (r = −0.29, p = 0.01) and fat mass (r = −0.28 and r = −0.26, all p < 0.05). 25(OH)D 3 is the metabolite that contributed most to this association. In conclusion, 25(OH)D 3 levels are related to anthropometric parameters in the postmenopausal women in this study, confirming insufficient status in the majority of the population. Approach strategies are necessary to correct and avoid this risk in order to ensure future quality of life.

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The level of vitamin D using the LC–MS/MS method and related factors in healthy Korean postmenopausal women

Cited by 4 publications

References 28 publications

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children’s study (JECS)

Association between Body Fatness and Vitamin D3 Status in a Postmenopausal Population

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