This qualitative systematic review aims to comprehensively understand the experiences and perspectives of nurses infected with COVID‐19, addressing a significant gap in the current literature. Following the JBI meta‐synthesis approach, a rigorous search was conducted across nine electronic databases and references until January 16, 2023. Seventeen eligible studies underwent quality assessment using the JBI critical checklist. Data were synthesized using standardized tools, and the ConQual tool evaluated confidence in the findings. Seven key findings emerged, providing valuable insights into emotional experiences, adaptation to COVID‐19 challenges, influence of support systems, coping strategies, posttraumatic growth perceptions, and effects on professional identity and career advancement. The findings highlight emotional toll, adaptive strategies, and professional implications for nurses. Moreover, they emphasize the importance of support systems, coping mechanisms, and posttraumatic growth in promoting nurses' well‐being and resilience. These insights have practical implications for targeted interventions and support mechanisms to enhance infected nurses' well‐being and improve healthcare outcomes.