The levels of human milk microRNAs and their association with maternal weight characteristics

Xi, Yangyang; Jiang, Xue; Li, R; Chen, M; Song, Wei; Li, X

doi:10.1038/ejcn.2015.168

Cited by 60 publications

(78 citation statements)

References 35 publications

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“…dFMR1 is not a conserved RISC component involved in RNAi as depletion of dFMR1 reduces RNAi efficiency in Drosophila S2 cells but not in mammals (Caudy et al, 2002). dFMR has been also implicated in the piRNA pathway (Bozzetti et al, 2015;Jiang et al, 2016).…”

Section: Additional Mirna and Rnai Factorsmentioning

confidence: 99%

“…Extracellular miRNAs were identified in a broad range of biological fluids (Pegtel et al, 2011;Huang et al, 2013;Kropp et al, 2014;Baglio et al, 2015;Dismuke et al, 2015;Wu et al, 2015). Apart from plasma, circulating miRNAs in milk are also intensely studied (Izumi et al, 2012;Kuruppath et al, 2013;Sun et al, 2013;Alsaweed et al, 2016c, b, a;Benmoussa et al, 2016;Xi et al, 2016).…”

Section: Extracellular Mirnas In Mammals and Their Transfermentioning

confidence: 99%

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Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Pačes

Nič²,

Novotný³

et al. 2017

EFS3

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This report is the outcome of an EFSA procurement aiming at investigating and summarising the state of knowledge on (I) the mode-of-action of dsRNA and miRNA pathways, (II) the potential for nontarget gene regulation by dsRNA-derived siRNAs or miRNAs, (III) the determination of siRNA pools in plant tissues and the importance of individual siRNAs for silencing. The report is based on a comprehensive and systematic literature search, starting with the identification and retrieval of~190,000 publications related to the research area and further filtered down with keywords to produce focused collections used for subsequent screening of titles and abstracts. The report is comprised of an (I) Introduction to the field of small RNAs, (II) a Data and Methodologies section containing strategies used for literature search and study selection, and (III) the Results of the literature review organized according to the three main procurement tasks. The outcome of the first task reviews dsRNA and miRNA pathways in mammals (including humans), birds, fish, arthropods, annelids, molluscs, nematodes, and plants. Eight taxon-dedicated chapters are based on~1,400 cumulative references chosen from~10,000 inspected titles and abstracts. We review conserved and divergent aspects of small RNA pathways and dsRNA responses in animals and plants including structure and function of key proteins as well as four basic mechanisms: genome-encoded posttranscriptional regulations (miRNA), degradation of RNAs by short interfering RNA pools generated from long dsRNA (RNAi), transcriptional silencing, and sequence-independent responses to dsRNA. The outcome of the second task focuses on base pairing between small RNAs and their target RNAs and predictability of biological effects of small RNAs in animals and plants. The outcome of the last task reviews methodology, siRNA pools, and movement of small RNAs in plants. Potential transfer of small RNAs between species and circulating miRNAs in mammals is described in the final chapter.

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Section: Additional Mirna and Rnai Factorsmentioning

confidence: 99%

Section: Extracellular Mirnas In Mammals and Their Transfermentioning

confidence: 99%

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Pačes

Nič²,

Novotný³

et al. 2017

EFS3

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“…Impact of maternal status on specific miRNA content in milk and their potential involvement in metabolic programming in offspring are not fully understood. There are some evidences suggesting that levels of several miRNAs in human milk are modulated by maternal diet, and some specific miRNAs in human milk are also affected by maternal weight . miRNA expression in dams and offspring's tissues are also influenced by maternal consumption of different types of fatty acids during early pregnancy .…”

Section: Introductionmentioning

confidence: 99%

Cafeteria Diet Consumption during Lactation in Rats, Rather than Obesity Per Se, alters miR‐222, miR‐200a, and miR‐26a Levels in Milk

Pomar

Castro

Picó

et al. 2019

Molecular Nutrition Food Res

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Scope The aim of the present study is to investigate in nursing rats the impact of cafeteria‐diet feeding during lactation (cafeteria dams) on specific miRNA levels in breast milk and to discern them from the effects of maternal adiposity per se (postcafeteria dams). Methods and results Milk samples are collected from control, cafeteria, and postcafeteria dams at three time points of lactation (days 5, 10, and 15) and levels of selected miRNAs (miR‐222, miR‐203, miR‐200a, miR‐103, miR‐27a, and miR‐26a) were determined. Levels in milk of miR‐222 rise while miR‐103 and miR‐27 fall throughout lactation. Moreover, at day 15 of lactation, cafeteria dams present higher miR‐222 and lower miR‐200a and miR‐26a levels in milk than controls. No differences are found in postcafeteria dams compared with controls. At weaning, the offspring of cafeteria dams, but not the offspring of postcafeteria dams, displays lower expression levels of Cdkn1c (a validated target gene of miR‐222) in liver than controls. Conclusion Cafeteria diet intake in nursing rats, rather than obesity per se, leads to alterations in specific miRNA levels, which, through the milk supply, may alter expression of target genes and potentially affect offspring phenotype.

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“…Studies investigating miRNA expression in relation to pre-pregnancy body mass index among pregnant women or their offspring, however, are few. 19–20 To our knowledge, only one recent study conducted in Europe, investigated circulating miRNAs in pregnancy in relation to pre-pregnancy body mass index (BMI). 21 In two well-characterized cohorts, the Omega study and the Pregnancy Outcomes and Community Health (POUCH) study, based in Washington State and Michigan, respectively, we conducted secondary analyses of epigenome-wide data to examine whether pre-pregnancy BMI is associated with early-mid pregnancy circulating miRNA expression.…”

Section: Introductionmentioning

confidence: 99%

Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy

Enquobahrie

Wander

Tadesse

et al. 2017

Obesity Research & Clinical Practice

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Background Maternal pre-pregnancy overweight and obese status has been associated with a number of pregnancy complications and adverse offspring outcomes. Mechanisms for observed associations, however, are largely unknown. We investigated associations of pre-pregnancy body mass index with early-mid pregnancy epigenetic biomarkers, circulating microRNAs. Methods Peripheral blood was collected from participants (16–27 weeks gestation) of two multi-racial pregnancy cohorts, the Omega Study and the Pregnancy Outcomes and Community Health Study. Plasma miRNA expression was characterized using epigenome-wide (319 miRNAs) profiling among 20 pregnant women in each cohort. Cohort-specific linear regression models that included the predictor (pre-pregnancy body mass index), the outcome (microRNA expression), and adjustment factors (maternal age, gestational age at blood collection, and race) were fit. Results Expression of 27 miRNAs was positively associated with pre-pregnancy body mass index in both cohorts (p-values<0.05). A number of these differentially expressed miRNAs have previously been associated with adipogenesis (e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b). Identified miRNAs as well as their experimentally validated targets participate in pathways that involve organismal injury, reproductive system disease, connective tissue disorders, cancer, cellular development, growth and proliferation. Conclusion Pre-pregnancy body mass index is associated with circulating miRNAs in early-mid pregnancy.

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The levels of human milk microRNAs and their association with maternal weight characteristics

Abstract: Adipogenesis miRNAs were expressed in both colostrum and mature milk and were related to maternal weight and infant gender. The miRNAs in human milk determined in this study provide a basis for future studies of their biological functions in infants.

Cited by 60 publications

References 35 publications

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Cafeteria Diet Consumption during Lactation in Rats, Rather than Obesity Per Se, alters miR‐222, miR‐200a, and miR‐26a Levels in Milk

Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy

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