The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia

Hendler, Israel; Blackwell, Sean C.; Mehta, Shobha; Whitty, Janice E.; Russell, E. S.; Sorokin, Yoram; Cotton, David B.

doi:10.1016/j.ajog.2005.06.041

Cited by 237 publications

(219 citation statements)

References 21 publications

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“…In the obese there is also a significant increase in serum leptin level, a hormone that regulates appetite and influences metabolic rate. 51 This suggests that fat reserves already stored prior to pregnancy are mobilised and hence impact on the macronutrient supply funnelled towards the fetus in the overweight and obese. This might have far-reaching implications in the context of the developmental origins of health and disease.…”

Section: Discussionmentioning

confidence: 99%

Maternal abdominal subcutaneous fat thickness as a predictor for adverse pregnancy outcome: a longitudinal cohort study

Kennedy

Peek

et al. 2015

BJOG

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Objective To assess maternal abdominal subcutaneous fat thickness (SFT) measured by ultrasound as an independent predictor of adverse pregnancy outcomes.Design A prospective longitudinal cohort study performed on pregnancies delivered between 2012 and 2014.Setting Sydney, Australia.Population About 1510 pregnant women attending routine obstetric ultrasounds.Methods Maternal SFT was measured on routine ultrasounds at 11-14 weeks' gestation (SFT1) and 18-22 weeks' gestation (SFT2). SFT measurements were assessed for estimating risks for obesityrelated pregnancy outcomes using logistic regression modelling adjusted for maternal age, parity, smoking status and body mass index (BMI).Main outcome measures Hypertensive disease, gestational diabetes, caesarean section, low birthweight, preterm delivery, neonatal respiratory distress, Apgar scores, and admission to a neonatal intensive care unit.Results SFT1 and SFT2 were measured on 1461 and 1363 women, respectively. Mean thickness (range) were 21.2 mm (6.9-73.9) for SFT1 and 20.3 mm (7.5-68.0) for SFT2. Complete outcome data were available for 1385 pregnancies. In all, 54% of the women were overweight/obese. The SFT measures decreased from early to mid-pregnancy in overweight/obese women. There was moderate correlation between BMI and SFT1 (R 2 = 0.56) and BMI and SFT2 (R 2 = 0.55). In a multivariate model, SFT1 and SFT2 were better predictors for adverse pregnancy outcomes than BMI.Conclusion Maternal SFT is a significant independent predictor of adverse pregnancy outcomes. Incorporation of SFT into future models for adverse pregnancy outcome may prove valuable.

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Section: Discussionmentioning

confidence: 99%

Maternal abdominal subcutaneous fat thickness as a predictor for adverse pregnancy outcome: a longitudinal cohort study

Kennedy

Peek

et al. 2015

BJOG

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“…40 Adipose tissue is not inert, 41 but synthesizes leptin according to fat stores and signals metabolic status to the brain. Both in non-pregnant and pregnant states, increasing BMI is related to increasing levels of leptin 42 and is related to pathology with increased levels seen in pre-eclamptic and diabetic women. 43 Data also point to the involvement of leptin in mood disturbances including stress.…”

Section: Possible Mechanismsmentioning

confidence: 99%

Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts

et al. 2007

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Objectives: We examine whether pregnancy weight (pre-pregnancy body mass index (BMI) and/or weight gain) is related to core symptoms of attention deficit hyperactivity disorder (ADHD) in school-age offspring. Design: Follow-up of prospective pregnancy cohorts from Sweden, Denmark and Finland within the Nordic Network on ADHD. Methods: Maternal pregnancy and delivery data were collected prospectively. Teachers rated inattention and hyperactivity symptoms in offspring. High scores were defined as at least one core symptom rated as 'severe' and two as 'present' (approximately 10% of children scored in this range). Logistic regression and latent class analyses were used to examine maternal pregnancy weight in relation to children's ADHD core symptoms. Results: Teacher rated 12 556 school-aged children. Gestational weight gain outside of the Institute of Medicine guidelines was not related to ADHD symptoms (below recommendations: odds ratio (OR): 0.96; 95% confidence interval (CI): 0.81, 1.14; above recommendations: OR: 0.98; 95% CI: 0.82, 1.16). To examine various patterns of pre-pregnancy BMI and weight gain, we used latent class analysis and found significant associations between classes that included pre-pregnancy overweight or obesity and a high ADHD symptom score in offspring, ORs ranged between 1.37 (95% CI: 1.07, 1.75) and 1.89 (95% CI: 1.13, 3.15) adjusted for gestational age, birth weight, weight gain, pregnancy smoking, maternal age, maternal education, child gender, family structure and cohort country of origin. Children of women who were both overweight and gained a large amount of weight during gestation had a 2-fold risk of ADHD symptoms (OR: 2.10, 95% CI: 1.19, 3.72) compared to normal-weight women. Conclusions: We show for the first time that pre-pregnancy BMI is associated with ADHD symptoms in children. Our results are of public health significance if the associations are causal and will then add ADHD symptoms in offspring to the list of deleterious outcomes related to overweight and obesity in the prenatal period.

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“…Maternal obesity is associated with a complex interplay of metabolic abnormalities including hypertension, insulin resistance, hyperlipidemia, hypercoagulability, impaired endothelial function, inflammatory up-regulation (4), and altered adipokine profiles (5), which potentially contribute to the development of preeclampsia (6) and gestational hypertension.…”

Section: Introductionmentioning

confidence: 99%

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study

Callaway

McIntyre

O’Callaghan

et al. 2007

American Journal of Epidemiology

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Obesity is an important risk factor for hypertensive disorders of pregnancy, but most cases of hypertensive disorders of pregnancy occur in women of normal weight. There may be predisposing factors to both hypertensive disorders of pregnancy and obesity. To test this hypothesis, the authors compared changes in body mass index (weight (kg)/height (m) 2 ) over time in women with and without hypertensive disorders of pregnancy. They used data from 3,572 women who received antenatal care at a major public hospital in Brisbane, Australia, between 1981 and 1984 and who were followed up for 21 years. A total of 318 women (8.9%) had experienced hypertensive disorders in the index pregnancy, and 233 of them (73.3%) had a baseline body mass index of 25 kg/m 2 . After the authors adjusted for all potential confounding factors, they found that women with hypertensive disorders of pregnancy gained on average 1.35 kg/m 2 more (95% confidence interval: 0.80 kg/m 2 , 1.89 kg/m 2 ) in body mass index over 21 years than women without hypertensive disorders of pregnancy. The odds of gaining 5 kg/m 2 were 59% greater for women who experienced hypertensive disorders of pregnancy compared with those who did not (odds ratio = 1.59, 95% confidence interval: 1.24, 2.04). The authors concluded that hypertensive disorders of pregnancy are associated with increased weight gain over 21 years. body mass index; body weight; hypertension; pre-eclampsia; pregnancy; prospective studies; weight gain; women Abbreviations: BMI, body mass index; HDP, hypertensive disorders of pregnancy

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The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia

Cited by 237 publications

References 21 publications

Maternal abdominal subcutaneous fat thickness as a predictor for adverse pregnancy outcome: a longitudinal cohort study

Maternal abdominal subcutaneous fat thickness as a predictor for adverse pregnancy outcome: a longitudinal cohort study

Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study

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