The levels of MDA-LDL in circulating immune complexes predict myocardial infarction in the VADT study

Lopes‐Virella, Maria F.; Hunt, Kelly J.; Baker, Nathaniel L.; Virella, Gabriel; Möritz, Thomas

doi:10.1016/j.atherosclerosis.2012.08.006

Cited by 46 publications

(38 citation statements)

References 28 publications

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“…Others have also shown the association of serum anti-MAA antibodies with diabetes [30], [31], and serum MAA-immune complexes with cardiovascular events in type 2 diabetic patients [32]. These data strongly suggest MAA has a role in CVD.…”

Section: Introductionmentioning

confidence: 77%

Unique Antibody Responses to Malondialdehyde-Acetaldehyde (MAA)-Protein Adducts Predict Coronary Artery Disease

et al. 2014

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Malondialdehyde-acetaldehyde adducts (MAA) have been implicated in atherosclerosis. The purpose of this study was to investigate the role of MAA in atherosclerotic disease. Serum samples from controls (n = 82) and patients with; non-obstructive coronary artery disease (CAD), (n = 40), acute myocardial infarction (AMI) (n = 42), or coronary artery bypass graft (CABG) surgery due to obstructive multi-vessel CAD (n = 72), were collected and tested for antibody isotypes to MAA-modifed human serum albumin (MAA-HSA). CAD patients had elevated relative levels of IgG and IgA anti-MAA, compared to control patients (p<0.001). AMI patients had a significantly increased relative levels of circulating IgG anti-MAA-HSA antibodies as compared to stable angina (p<0.03) or CABG patients (p<0.003). CABG patients had significantly increased relative levels of circulating IgA anti-MAA-HSA antibodies as compared to non-obstructive CAD (p<0.001) and AMI patients (p<0.001). Additionally, MAA-modified proteins were detected in the tissue of human AMI lesions. In conclusion, the IgM, IgG and IgA anti-MAA-HSA antibody isotypes are differentially and significantly associated with non-obstructive CAD, AMI, or obstructive multi-vessel CAD and may serve as biomarkers of atherosclerotic disease.

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Section: Introductionmentioning

confidence: 77%

Unique Antibody Responses to Malondialdehyde-Acetaldehyde (MAA)-Protein Adducts Predict Coronary Artery Disease

et al. 2014

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“…AGEs have been reported to be associated with traits including age (Jiang et al, 2012, Lopes-Virella et al, 2012), BMI, and waist to hip ratio (Amin et al, 2011), as well as gender (Jiang et al, 2012, B. K. Kilhovd, 2007) and a range of CVD risk factors including measures of blood pressure (Sourris et al, 2014), smoking (Fukushima et al, 2013), and LDL cholesterol (Lopes-Virella et al, 2012). However, the literature is conflicted.…”

Section: Discussionmentioning

confidence: 99%

“…Part of the reason for this complication is there is no consistent method of detecting AGEs, internal standards, nor standardized unit of measurements that are universally accepted (Singh et al, 2001). Multiple studies have suggested there is no association between AGEs and blood pressure (Lopes-Virella et al, 2012, Fukushima et al, 2013). Lopes-Virella et al also found no association between AGEs and BMI (Lopes-Virella et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Analysis of advanced glycation end products in the DHS Mind Study

Adams

Martelle

Raffield

et al. 2016

Journal of Diabetes and its Complications

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Aims Human studies of links between advanced glycation end-products (AGEs) and disease phenotypes are less common than studies of animal and cell models. Here, we examined the association of total AGEs with diabetes risk factors in a predominately type 2 diabetes (T2D) affected cohort. Methods AGEs were measured using an enzyme linked immunosorbant assay in 816 individuals from the DHS Mind Study (n=709 T2D affected), and association analyses were completed. Results Total AGEs were associated with estimated glomerular filtration rate (p= 0.0054; β= −0.1291) and coronary artery calcification (p= 0.0352; β= 1.1489) in the entire cohort. No significant associations were observed when individuals with T2D were analyzed separately. In individuals without T2D, increased circulating AGEs were associated with increased BMI (p= 0.02, β = 0.138), low density lipoproteins (p=0.046, β = 17.07) and triglycerides (p= 0.0004, β = 0.125), and decreased carotid artery calcification (p= 0.0004, β = −1.2632) and estimated glomerular filtration rate (p= 0.0018, β = −0.1405). Strong trends were also observed for an association between AGEs and poorer cognitive performance on the digit symbol substitution test (p=0.046, β = −6.64) and decreased grey matter volume (p=0.037, β = −14.87). Conclusions AGEs may play an important role in a number of phenotypes and diseases, although not necessarily in interindividual variation in people with T2D. Further evaluation of specific AGE molecules may shed more light on these relationships.

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“…The IgG auto-antibodies reacting with modified forms of LDL generate immune complexes [27] which could activate human macrophages and impact oxidative stress [28]. One of the oxidized forms, MDA-LDL, has been suggested as a diagnostic marker of coronary artery disease [11], plaque vulnerability [12], and acute coronary syndrome [13] and MDA-LDL immune complexes as a predictor of future myocardial infarction [29]. Also in our study, although the discriminating power of MDA-LDL for adverse events estimated by ROC analysis is not especially high on its own, it could be an important indicator of MACE after DES-PCI.…”

Section: Mda-ldl As An Indicator Of Late Adverse Clinical Events Aftementioning

confidence: 99%

Malondialdehyde-modified low-density lipoprotein is a predictor of cardiac events in patients with stable angina on lipid-lowering therapy after percutaneous coronary intervention using drug-eluting stent

Ito¹,

Fujita²,

Tani³

et al. 2015

Atherosclerosis

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The levels of MDA-LDL in circulating immune complexes predict myocardial infarction in the VADT study

Cited by 46 publications

References 28 publications

Unique Antibody Responses to Malondialdehyde-Acetaldehyde (MAA)-Protein Adducts Predict Coronary Artery Disease

Unique Antibody Responses to Malondialdehyde-Acetaldehyde (MAA)-Protein Adducts Predict Coronary Artery Disease

Analysis of advanced glycation end products in the DHS Mind Study

Malondialdehyde-modified low-density lipoprotein is a predictor of cardiac events in patients with stable angina on lipid-lowering therapy after percutaneous coronary intervention using drug-eluting stent

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