The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia

Abstract

Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-α and IL-6 in CAE patients. Methods. Plasma concentrations of TNF-α and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2 ± 12 years), and results were compared with age and sex-matched controls (n = 32) without coronary artery ectasia. TNF-α and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA). Results. Baseline characteristics of the two groups were similar. TNF-α and IL-6 levels were significantly higher in CAE group than controls (15.6 ± 11.2 pg/mL versus 7.8 ± 3.7 pg/mL, P < .001, and 17.2 ± 12.6 versus 7.6 ± 2.1 P < .0001, resp.). Conclusion. CAE patients showed increases in TNF-α and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-α and IL-6 levels.

Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease

“…However, some investigations assessing the role of inflammation in adult patients with coronary artery ectasia were conducted, and these studies reported higher levels of serum (IL)-6 and (TNF)-α, together with the accumulation of inflammatory cells in the medial layer of coronary arteries (27)(28)(29). Some other studies additionally found higher neutrophil to lymphocyte ratios in patients with coronary artery ectasia than in healthy controls, and they denoted that neutrophils cause important changes in vascular tissue by release of elastase, myeloperoxidase, free-oxygen radicals, and various hydrolytic enzymes (11,30).…”

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

“…Koroner arter ektazisi sıklığı farklı anjiyografik serilerde %0.2 ile %10 arasında rapor edilmiştir (1,3,15,18,19). Bizim çalışma-mızda KAE sıklığı %5.6 idi.…”

“…Bunu sol ön inen arter ve sirkumfleks arter izler. Ana koroner arterde ektazi oldukça nadirdir (1,19,20). Sıklığı açısından bizim çalışmamızda -da literatürde belirtildiği gibi-KAE en sık sağ koroner arterde görülmektedir (LAD, CX ve RCA için sırası ile %25, 33 ve 42) (1,3,15,(18)(19)(20).…”

Two Locations, Two Hits; Two Faces of The Sword: Co-Existence of Coronary and Cerebral Arterial Aneurysms

“…CA detected in 0.3%-5.3% of consecutive angiographic studies (3,4). Etiology of CA include atherosclerosis (%50), congenital anomalies (20%-30%), syphilis, polyarteritis nodosa, Takayasu arteritis, Kawasaki disease, scleroderma, Ehlers-Danlos syndrome, trauma (percutaneous coronary intervention), bacterial and mycotic infections, nitrite and herbicide products exposure (5), and other rare causes such as adult polycystic kidney disease (6).…”