The Lewis blood factors in American negroes

Miller, Edward B.; Rosenfield, Richard E.; Vogel, Peter; Haber, Gladys V.; Gibbel, Natalie

doi:10.1002/ajpa.1330120316

Cited by 48 publications

(26 citation statements)

References 11 publications

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“…formed by Le(a-b-) ABH non-secretors [104]. At first, this may seem surprising, but when it is appreciated that Le(ab-) non-secretors make small amounts of Lea, and Le(a-b-) secretors make small amounts of Leb [42], this is not un expected.…”

Section: Tissue Origin Of Plasma Lewis Glycolipidsmentioning

confidence: 99%

“…There is little orno serologically detectable Lea or Leb antigen in the saliva or plasma, although trace amounts of Lewis activity and cross-reactivity can be de tected [38,42,104,116]. Lea has been found in Le(a-b-) non-secretors' plasma and intestinal samples ( fig.…”

Section: Le(a-b-)mentioning

confidence: 99%

“…Similarly, low levels of Lewis antigens in the saliva of Lewis-negative individuals [38,104], and other related substances can also inhibit Lewis antiserum. Some monoclonal reagents, although spe cific for a given determinant on the intact red cell, may be neutralised by a related epitope in saliva, i.e.…”

Section: Salivaiy Abh and Lewis Substancesmentioning

confidence: 99%

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Lewis Histo-Blood Group System and Associated Secretory Phenotypes

Henry¹,

Oriol²,

Samuelson³

1995

Vox Sanguinis

127

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This review summarises present knowledge of the chemistry, immunology, genetics and clinical significance of antibodies in the Lewis and secretor histo- blood group systems. Although red cell serology has laid the foundations for these systems, more recent advances have been made by studying Lewis and related glycoconjugates with monoclonal antibodies, determining structures by mass spectrometry and NMR spectroscopy, identifying enzymes and their specificities, and identifying the genes by molecular biology. The expression of Lewis system antigens is dependent on Lewis and secretor loci. Fucosyltrans- ferases coded by genes at these loci compete and interact with each other and with other transferases to determine an individual’s Lewis and secretor phenotype. Exocrine epithelial cells, mostly of endodermal origin, synthesise the Lewis antigens which, as plasma glycolipids, are secondarily acquired by cells of the peripheral circulation. Phenotyping red cells is often regarded as a simple way of determining the Lewis and sometimes the secretor status of an individual; however, the red cell phenotype is influenced by many factors and may not necessarily reflect someone’s Lewis and secretor genotypes. Two main red cell Lewis groups are usually found, Lewis negative and Lewis positive. In Lewis-negative individuals, the secretor genotype does not affect the Lewis phenotype, but in Lewis-positive individuals, the non-secretor genotype generates the Le(a+b-) phenotype, the secretor genotype causes the Le(a-b+ ) phenotype, and the partial secretor genotype gives rise to the Le(a+b+) phenotype.

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Section: Tissue Origin Of Plasma Lewis Glycolipidsmentioning

confidence: 99%

Section: Le(a-b-)mentioning

confidence: 99%

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Lewis Histo-Blood Group System and Associated Secretory Phenotypes

Henry¹,

Oriol²,

Samuelson³

1995

Vox Sanguinis

127

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“…Other investigators (Makni et al, 1987;Miller et al, 1954;Mollicone et al, 1994;∅rntoft et al, 1991;Palatnik et al, 1987) have reported the existence of paradoxical erythrocyte/saliva discordance, that may have been explained previously by the presence of the weak Lewis allele (Le w ), which originates a fucosyltransferase that is less efficient than that codified by the dominant allele, thus determining a quantitative variation.…”

Section: Discussionmentioning

confidence: 98%

“…The frequency of Le(a-b-) in American Blacks is almost 30%, and some individuals secrete Lewis substances in their saliva (Miller et al, 1954). In African populations, the same phenotype can reach 40% (Mourant et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

2002

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The expression of the ABH and Lewis blood groups was determined in blood and saliva samples from two semi-isolated Black communities of Northern Brazil: Cametá and Alcântara. The distributions of ABO blood group phenotypes and the ABH secretor status frequencies showed no significant differences between these populations. In contrast, there was a difference regarding the frequency of the red blood cell Le(a-b-) phenotypes, associated with erythrocyte/saliva discordance, as confirmed by the observation that individuals with Le(a-b-) red cells have the Lewis antigen in their saliva, resulting in a nongenuine Le(a-b-) phenotype, whose frequency was higher in Alcântara.

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ABO, Lewis and P Groups and Ii Antigens

Klein¹,

Anstee²

2005

Mollison's Blood Transfusion in Clinical Medicine

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The Lewis blood factors in American negroes

Cited by 48 publications

References 11 publications

Lewis Histo-Blood Group System and Associated Secretory Phenotypes

Lewis Histo-Blood Group System and Associated Secretory Phenotypes

The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

ABO, Lewis and P Groups and Ii Antigens

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