This research article aims to use Universal Design for Learning (UDL) and digital fabrication (DF) to create a tool for the inclusive teaching of chemistry, with the specific purpose of enhancing the teaching-learning process in organizing chemical elements. The Design-Based Research (DBR) methodology was employed. This methodology facilitated the design of a tool based on an alternative ordering to the traditional periodic table. Utilizing the principles of Universal Design for Learning and the implementation of digital fabrication technologies, especially 3D printing, it has been possible to link student-centered learning, inquiry-based learning, and hands-on learning. Experimental activities have been carried out with students and teachers from three schools in Catalonia, Spain, as well as validation with experts from the Spanish National Organization for the Blind (ONCE). The assessment discussion and analysis made by students, teachers and experts using mixed methods (quantitative and qualitative) is given. This research has exposed the synergy between universal design for learning and digital fabrication in learning and its contribution to improve the inclusive teaching-learning process.