2022
DOI: 10.1007/s00586-021-07092-9
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The lexicon for periprosthetic bone loss versus osteolysis after cervical disc arthroplasty: a systematic review

Abstract: Background Periprosthetic bone loss is a common observation following arthroplasty. Recognizing and understanding the nature of bone loss is vital as it determines the subsequent performance of the device and the overall outcome. Despite its significance, the term “bone loss” is often misused to describe inflammatory osteolysis, a complication with vastly different clinical outcomes and treatment plans. Therefore, the goal of this review was to report major findings related to vertebral radiograp… Show more

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Cited by 14 publications
(18 citation statements)
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References 63 publications
(137 reference statements)
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“…Therefore, the cause of the observed osteolysis could not be determined. Regardless, the etiology of osteolysis is rarely studied in spinal implants and, specifically, the multifactorial relationship between osteolysis and successful fixation remains unclear, requiring further exploration 20 . Furthermore, the age of the patients included in this study was quite different (66 years vs. 36 years), which may have influenced the potential for bony ongrowth.…”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, the cause of the observed osteolysis could not be determined. Regardless, the etiology of osteolysis is rarely studied in spinal implants and, specifically, the multifactorial relationship between osteolysis and successful fixation remains unclear, requiring further exploration 20 . Furthermore, the age of the patients included in this study was quite different (66 years vs. 36 years), which may have influenced the potential for bony ongrowth.…”
Section: Discussionmentioning
confidence: 99%
“…[15][16][17] Further, case reports have identified infection and osteolysis as rare complications in M6-C devices. [18][19][20][21] Unfortunately, M6-L clinical studies and case reports are relatively rare, with the majority of studies assessing short-term outcomes and reporting overall reduction in pain and restoration of motion. 22,23 Furthermore, the presence of bony ongrowth and overall fixation of these devices have not been assessed for the M6 cervical or lumbar devices.…”
Section: Discussionmentioning
confidence: 99%
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“…Nevertheless, plain radiographic assessment remains the front-line patient assessment tool for cTDR [ 12 , 16 ]. Previous studies have underscored the need for classification of radiographic changes around cTDR including heterotopic ossification (HO) [ 17 , 18 ] and bone loss [ 12 , 19 ]. Bone loss around orthopedic implants can result from sepsis [ 20 , 21 ], or aseptically due to bone adaptation or remodeling due to stress shielding (sometimes referred to as “Wolff’s law”) [ 22 ], osteoporosis [ 23 ], fluid pressure [ 24 ], as well as the well-described chronic inflammatory reaction to wear debris termed “osteolysis” in peripheral joint arthroplasty [ 19 ].…”
Section: Introductionmentioning
confidence: 99%