The liberating force of ultrasound

Boulatov, Roman

doi:10.1038/s41557-020-00623-9

Cited by 13 publications

(15 citation statements)

References 12 publications

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“…A US mechanophore breakage (mechanochemical breakage of the polymer reactive units like cyclic rings) can occur in extracts’ solutions via the shear stress caused by the collapse of US-induced cavitation bubbles [ 37 , 38 ]. These modifications in the structure of extracted compounds caused by US can facilitate the bioavailability of the bioactive molecules extracted from plants [ 16 ]. However, the US higher than 50% had a negative effect on the PAs due to the formed radicals and H 2 O 2 by the cavitation’s bubbles [ 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…Xu et al [ 21 ] reported that 40 mL/g of S/S was the most efficient solvent concentration, which improved the solubility of PAs in the plant cells. Boulatov [ 16 ] reported that the US mechanochemistry affected overstretching carbohydrates’ polymers that lead to their fragmentation, which helps in releasing small molecules that are bound in their polymer chain.…”

Section: Resultsmentioning

confidence: 99%

“…For example, using US for extraction of PAs from different plant origins like grape seeds and knotweed rhizome bark at 40 °C for 15–20 min enhanced their extracted yields [ 14 , 15 ]. Boulatov [ 16 ] reported that the mechanochemical effects of the US results in overstretching of macromolecule polymers (like carbohydrate and protein chains) that lead to their fragmentation and release of phytochemicals. A comparison study of US-assisted and conventional extraction methods on tea leaves’ bioactive compounds showed that the breakdown of cells cytoarchitecture by US increased 20% of extracted bioactive phenolics [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound-Assisted Extraction Optimization of Proanthocyanidins from Kiwi (Actinidia chinensis) Leaves and Evaluation of Its Antioxidant Activity

Gouda

Zhu

et al. 2021

Antioxidants

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Using ultrasound (US) in proanthocyanidin (PA) extraction has become one of the important emerging technologies. It could be the next generation for studying the US mechnophore impact on the bioactive compound’s functionality. The objective of this study was to demonstrate the potential of US treatment on PAs extracted from kiwifruit (Actinidia chinensis) leaves, and to provide a comprehensive chemical composition and bioactivity relationship of the purified kiwifruit leaves PAs (PKLPs). Several methods like single-factor experiments and response surface methodology (RSM) for the four affected factors on US extraction efficiency were constructed. HPLC-QTOF-MS/MS, cytotoxicity analysis, and antioxidant activity were also demonstrated. In the results, the modeling of PA affected factors showed that 40% US-amplitude, 30 mL/g dry weight (DW) solvent to solid ration (S/S), and 70 °C for 15 min were the optimum conditions for the extraction of PAs. Furthermore, PKLPs exhibited significant radical scavenging and cellular antioxidant activity (p < 0.05). In conclusion, this study’s novelty comes from the broad prospects of using US in PKLP green extraction that could play an important role in maximizing this phytochemical functionality in drug discovery and food science fields.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound-Assisted Extraction Optimization of Proanthocyanidins from Kiwi (Actinidia chinensis) Leaves and Evaluation of Its Antioxidant Activity

Gouda

Zhu

et al. 2021

Antioxidants

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“…Beside, ones may keep eyes on novel drug liberation mechanism such as mechanochemistry. [252] The detailed mechanism of nanoprodrug assembling remains in its infancy therefore deserve more investigation, in particular the behavior of NPs at fluid-fluid interface. [253] The in situ observation of NPs formation, growth process and trajectory tracking are often technologically challenged and expensive.…”

Section: Remark and Outlookmentioning

confidence: 99%

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

et al. 2021

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This article provides a broad spectrum about the nanoprodrug fabrication advances co-driven by prodrug and nanotechnology development to potentiate cancer treatment. The nanoprodrug inherits the features of both prodrug concept and nanomedicine know-how, attempts to solve underexploited challenge in cancer treatment cooperatively. Prodrugs can release bioactive drugs on-demand at specific sites to reduce systemic toxicity, this is done by using the special properties of the tumor microenvironment, such as pH value, glutathione concentration, and specific overexpressed enzymes; or by using exogenous stimulation, such as light, heat, and ultrasound. The nanotechnology, manipulating the matter within nanoscale, has high relevance to certain biological conditions, and has been widely utilized in cancer therapy. Together, the marriage of prodrug strategy which shield the side effects of parent drug and nanotechnology with pinpoint delivery capability has conceived highly camouflaged Trojan horse to maneuver cancerous threats.

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“…[ 17 ] Recently, we provided the first example of US‐induced mechanochemical bond scission for the activation of drugs, underlining the potential of US for spatial and temporal regulation of medication. [ 18 , 19 ] Furthermore, the combination of nanoparticle systems with polymer mechanochemistry enabled increased drug loading efficiency and enhanced mechanical responses compared to systems relying exclusively on synthetic polymers. [ 20 ]…”

Section: Introductionmentioning

confidence: 99%

Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation

et al. 2022

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Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables the remote‐controlled drug release from their inactive parent macromolecules using ultrasound (US). To further expand the scope of the US‐controlled drug activation strategy, herein a mechano‐responsive nanoswitch for the selective activation of doxorubicin (DOX) to inhibit cancer cell proliferation is constructed. As a proof‐of‐concept, the synthesis, characterization, and US‐responsive drug activation evaluation of the mechano‐nanoswitch, which provides a blueprint for tailoring nanosystems for force‐induced pharmacotherapy is presented.

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The liberating force of ultrasound

Cited by 13 publications

References 12 publications

Ultrasound-Assisted Extraction Optimization of Proanthocyanidins from Kiwi (Actinidia chinensis) Leaves and Evaluation of Its Antioxidant Activity

Ultrasound-Assisted Extraction Optimization of Proanthocyanidins from Kiwi (Actinidia chinensis) Leaves and Evaluation of Its Antioxidant Activity

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation

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