The Lifestyle Interventions and Independence for Elders Pilot (LIFE-P): 2-Year Follow-up

Rejeski, W. Jack; Marsh, Anthony P.; Chmelo, Elizabeth; Prescott, Abbie J.; Dobrosielski, Meredith A.; Walkup, Michael P.; Espeland, Mark A.; Miller, Michael E.; Kritchevsky, Stephen B.

doi:10.1093/gerona/gln041

Cited by 86 publications

(80 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Is associated with Frailty ↓ IGF-1, ↓ DHEAS, ↓ free testosterone [77] IGF insulin-like growth factor, DHEAS dehydroepiandrosterone sulfate hormones is clear, and there is also a decrease in dehydroepiandrosterone (sulfate), growth hormone and IGF-1 [69]. Abnormal hormone levels in women are also associated with frailty (Table 4).…”

Section: Pathophysiologymentioning

confidence: 99%

“…A real-life primary outcome, even if improvements in surrogates are achieved, should be based on dependency. The ongoing lifestyle interventions and independence for elders study (The LIFE study), a multicenter Phase III trial of physical activity or health education in 1,600 high-risk sedentary older persons, has operationalized the primary outcome of major mobility disability as the inability to perform the 400-meter walk [77,78].…”

Section: The Way Aheadmentioning

confidence: 99%

See 1 more Smart Citation

Frailty and sarcopenia: definitions and outcome parameters

et al. 2012

View full text Add to dashboard Cite

An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.

show abstract

Section: Pathophysiologymentioning

confidence: 99%

Section: The Way Aheadmentioning

confidence: 99%

Frailty and sarcopenia: definitions and outcome parameters

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Despite the limited number of studies comparing the effects of strength training, endurance training, and concurrent training interventions on functional test performance, it is important to highlight the positive effect of concurrent training on the functional capacity of elderly populations (Binder et al 2004;Pahor et al 2006;Rejeski et al 2009;Izquierdo et al 2012). In the study by Rejeski et al (2009), 2 years of combined endurance and strength training resulted in an improved 400-m walking speed and physical performance battery that included balance, 4 m of selfpaced walking speed, and chair stands.…”

Section: Long-term Concurrent Training Programsmentioning

confidence: 99%

“…In the study by Rejeski et al (2009), 2 years of combined endurance and strength training resulted in an improved 400-m walking speed and physical performance battery that included balance, 4 m of selfpaced walking speed, and chair stands. In another study, Binder et al (2004) demonstrated enhanced scores in an assessment of muscle strength, gait, balance, body composition, and quality of life after 5 years of a physical therapy program that was composed of strength and endurance training in elderly men and women who had experienced surgical repair of a proximal femur fracture.…”

Section: Long-term Concurrent Training Programsmentioning

confidence: 99%

How to simultaneously optimize muscle strength, power, functional capacity, and cardiovascular gains in the elderly: an update

Izquierdo

2013

AGE

View full text Add to dashboard Cite

The purpose of the present study was to review the scientific literature that investigated concurrent training adaptations in elderly populations, with the aim of identifying the optimal combination of both training program variables (i.e., strength and endurance) to avoid or minimize the interference effect in the elderly. Scielo, Science Citation Index, MEDLINE, Scopus, SPORTDiscus, and ScienceDirect databases were searched. Concurrent training is the most effective strategy by which to improve neuromuscular and cardiorespiratory functions as well as functional capacity in the elderly. The volume and frequency of training appears to play a critical role in concurrent training-induced adaptations in elderly subjects. Furthermore, new evidence indicates that the intra-session exercise order may influence the magnitude of physiological adaptations. Despite the interference effect on strength gains that is caused by concurrent training, this type of training is advantageous in that the combination of strength and endurance training produces both neuromuscular and cardiovascular adaptations in the elderly. The interference phenomenon may be observed in elderly subjects when a moderate weekly volume of concurrent training (i.e., three times per week) is performed. However, even with the occurrence of this phenomenon, the performance of three concurrent training sessions per week appears to optimize the strength gains in relative brief periods of training (12 weeks). Moreover, performing strength prior to endurance exercise may optimize both neuromuscular and cardiovascular gains.

show abstract

“…This might suggest that in older individuals regular physical activity may provide physiological improvements which in turn reduce "the rate of aging" [25]. A number of reports from large epidemiological studies have shown that increasing habitual physical activity prevents the decline in mobility-related physical performance in older adults [26][27][28][29][30][31]. These studies assessed habitual physical activity using subjective reports (i.e., questionnaires) [32].…”

Section: Introductionmentioning

confidence: 99%

The Applicability of the Activities of Daily Living Age Scale in Japanese Community-Dwelling Adults Aged 75 Years or Older

Seino¹

2015

Fam Med Med Sci Res

View full text Add to dashboard Cite

Our aim is to investigate the applicability of the activities of daily living age scale (ADLA) through the examination of the degree to which physical functionality is enhanced by habitual exercise in older Japanese aged 75 years and older. Participants comprised 598 community-dwellings older Japanese (386 women 79.0 ± 3.5 and 212 men 79.1 ± 3.8), who were divided in 2 groups of a non-exercise (NE) and an active group (A). The ADLA equation is an instrument that estimates participants' physical functioning regarding ADL using data obtained previously from 1006 subjects. All participants completed a comprehensive battery of 3 physical performance items that formed the basis for the ADLA equation. The developed equations are as follow: ADLA for women = 0.447 (chronological age: CA) -5.49 (ADL scoreADLS) + 44.17; and ADLA for men = 0.519CA -4.27ADLS + 38.26. In women the mean of ADLA of NE group (78.9 ± 4.3 years) were significantly lower than their mean of CA (79.4 ± 3.5 years, p<0.05). Meanwhile there were no significant difference among the mean of ADLA of the NE group in men (80.0 ± 5.1 years) and their mean of CA (79.7 ± 4.2). The ADLA mean of A group in women (76.3 ± 3.7 years) and in men (77.3±3.4 years) were significantly lower than their mean of CA (78.6 ± 3.5 and 78.4 ± 3.3 years, p<0.01) respectively. The result indicates that ADLA scale has validity application. Through the responsiveness of the ADLA scale we conclude that exercise habituation affects overall physical function even on people over 75 years and older, possessing significantly higher level of physical fitness than those who do not exercise regularly. They showed a remarkably older ADLA.

show abstract

The Lifestyle Interventions and Independence for Elders Pilot (LIFE-P): 2-Year Follow-up

Abstract: Older adults who have compromised physical function are able to sustain some of the benefits derived from participating in structured PA 2 years after supervised treatment has been terminated.

Cited by 86 publications

References 15 publications

Frailty and sarcopenia: definitions and outcome parameters

Frailty and sarcopenia: definitions and outcome parameters

How to simultaneously optimize muscle strength, power, functional capacity, and cardiovascular gains in the elderly: an update

The Applicability of the Activities of Daily Living Age Scale in Japanese Community-Dwelling Adults Aged 75 Years or Older

Contact Info

Product

Resources

About