Highlights Hydro-fracturing is extensively used to increase the well productivity index, particularly in unconventional, tight and ultra-tight reservoirs. This expensive procedure, though, sometimes fails to meet expectations regarding the production enhancement. The leading explanations for this reduced performance is fracture clean-up inefficiency of the fracturing fluid (FF) that was primarily injected. In this study, a parametric investigation of FF clean-up effectiveness of fractures was performed with 143360 simulations (in 35 different sets) including injection, shut-in and production stages. Results pointed out that in general, factors that control the mobility of FF inside the fracture had the most significant impact on cleanup efficiency. Conversely, in tight and ultratight sets, particularly when the applied pressure drawdown for the duration of production stage was small, the impact of fluid mobility within the matrix on gas production loss was more noticeable, i.e., it is crucial how fluids flow inside the matrix rather than how fast fracture is cleaned. The larger the Pc the lower the production loss. The impact of Pc on GPL minimisation was stronger when pressure drawdown was small and/or shut-in time was prolonged. As the formation becomes tighter, this observation was more pronounced, in other words, for such formations, the impact of a change in pressure drawdown and/or shut-in time on Pc and GPL was more noticeable. The impact of Pc on minimising GPL is less noticeable in shorter fractures and vice versa. As the length of fracture reduced, quicker fracture clean-up was detected compared to those for longer fracture. These discoveries help us to better understand the hydraulic fracturing process and can be used to settle issues regarding the performance of hydraulic fracturing and to improve the design of hydro-fracturing operations, which is an expensive but popular stimulation method for tight and ultra-tight reservoirs.