“…In applications requiring metal-based or polymerbased microscale structures, the Lithographie, Galvanoformung, Abformung (LIGA) process is the preferred fabrication technology. The LIGA process, first developed using X-ray lithography of PMMA (Menz et al 1991;Mohr et al 1992;El-Kholi et al 1993;Kondo et al 1998;Ehrfeld and Schmidt 1998;Henry et al 1999;Guckel et al 2000;Singleton et al 2002;Schulz and Bade et al 2004;Heckele and Schomburg 2004), has been used to fabricate high-aspect-ratio microscale structures (HARMS) for applications in mechanical, electrical, chemical, and biomedical devices and systems (Menz et al 1991;Mohr et al 1992;El-Kholi et al 1993;Kondo et al 1998;Ehrfeld and Schmidt 1998;Henry et al 1999;Guckel et al 2000;Singleton et al 2002;Schulz and Bade et al 2004;Heckele and Schomburg 2004), including micro accelerator (Qu et al 1999), RF inductor (Sadler et al 2001), micro mixer/reactor (Yang et al 2004), polymerase chain reaction (PCR) system (Hupert and Witek 2003), and others. The molding replication step of the three-step LIGA process of lithography, electrodeposition, and molding is the most important for low-cost HARMS production.…”