The generation of machine tool spindle vibration is becoming prevalent as high-speed machining and lightweight design are being actively applied in the machining process. As the required machining accuracy increases, the machine tool spindle vibration generated in ultra-precision machining is the main cause of the deterioration of the machining quality. In this study, a TiC-SKH51 metal-matrix composite was used to suppress the machine tool spindle vibration. A vibration characteristic test was conducted to obtain the dynamic characteristics of the TiC-SKH51 and other testing materials. By comparing the results of the vibration characteristic test, the reliability of the finite element analysis software was confirmed. Then, dynamic and static analyses were performed to obtain the dynamic and static characteristics of the machine tool spindle model. The analysis results show that the TiC-SKH51 machine tool spindle can directly suppress the generation of spindle vibrations.