Rivers host a myriad of invisible chemical solutes that define the baseline quality of life-sustaining flowing waters. River chemistry reflects the response of Earth's Critical Zone, the zone from the tree top to the bottom of groundwater, to external climate forcing and human perturbations (Brantley et al., 2017). River water originates from precipitation, most of which infiltrates and flows via subsurface and river corridors (Figure 1). Along its journey, water mobilizes solutes by interacting with roots, microbes, soils, sediments, and rocks. As it eventually exits at river outlets, it carries the chemical signature of its interactions along its flow paths, and reflect the relative magnitude of biogeochemical reactions that produce solutes and export processes that transport solutes (Li et al., 2021).River chemistry is essential in regulating carbon-climate feedbacks, water quality, and aquatic ecosystem health. Solutes such as dissolved organic and inorganic carbon (DOC and DIC) and nutrients readily transform in rivers and emit greenhouse gases including CO 2 , N 2 O, and CH 4 (