The Linear Behavior of the System Middle Cerebral Artery Flow Velocity and Blood Pressure in Patients With Migraine

Müller, Martin; Marziniak, Martin

doi:10.1161/01.str.0000177886.94134.92

Cited by 37 publications

(30 citation statements)

References 23 publications

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“…It has previously been reported that dCA is impaired in migraineurs [9], [18]. Müller et al studied 22 migraine patients and 33 healthy controls and found that dCA phase and gain appeared to be completely different in migraineurs compared with healthy controls [9].…”

Section: Discussionmentioning

confidence: 96%

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Compromised Dynamic Cerebral Autoregulation in Patients with a Right-to-Left Shunt: A Potential Mechanism of Migraine and Cryptogenic Stroke

et al. 2014

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Background and PurposeThe relationship between right-to-left shunts (RLS) and migraine and cryptogenic stroke is not well understood. In this study, we investigated whether RLS are associated with impairment of dynamic cerebral autoregulation (dCA), which may play a role in migraine and cryptogenic stroke.MethodsSixty-six migraineurs were enrolled in the study, including 36 non-RLS patients and 30 RLS patients. Non-invasive continuous cerebral blood flow velocity and arterial blood pressure were recorded simultaneously from each patient by using transcranial Doppler and servo-controlled plethysmograph, respectively. Transfer function analysis was applied to derive autoregulatory parameters of gain, phase difference (PD), and autoregulation index.ResultsThe PD in migraineurs with RLS was 50.6±22.9 degrees, which was significantly lower than that observed in the non-RLS group (67.2±18.2 degrees, P<0.001). The PD in the large RLS group (45.4±22.6 degrees) was significantly lower than that of the small RLS group (64.9±17.1 degrees, P<0.01) and non-RLS group (P<0.001); however, the PD in the small RLS group was similar to that of the non-RLS group. The PD in the permanent group (48.8±19.9 degrees) was similar to that of the latent group (52.6±26.1 degrees), and both were significantly lower than that of the non-RLS group (P<0.05). The autoregulation index results were similar to the PD findings.ConclusionsdCA is impaired in migraineurs with large RLS, and this may represent a potential mechanism linking RLS, migraine, and cryptogenic stroke.

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Section: Discussionmentioning

confidence: 96%

“…Müller et al studied 22 migraine patients and 33 healthy controls and found that dCA phase and gain appeared to be completely different in migraineurs compared with healthy controls [9]. They suggested that this might be due to the lack of sympathetic and parasympathetic control of CBFV [9].…”

Section: Discussionmentioning

confidence: 99%

Compromised Dynamic Cerebral Autoregulation in Patients with a Right-to-Left Shunt: A Potential Mechanism of Migraine and Cryptogenic Stroke

et al. 2014

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“…Muller and Marziniak used frequency analysis of dynamic cerebral autoregulation to assess whether blood flow regulation disturbances may be found at the same frequencies of sympathetic and parasympathetic activity (35), and interpreted the impaired autoregulation observed in migraine patients as a possible lack of sympathetic and parasympathetic control of cerebral blood flow.…”

Section: Discussionmentioning

confidence: 99%

Increased Cerebral Vasomotor Reactivity in Migraine With Aura: An Autoregulation Disorder? A Transcranial Doppler and Near-Infrared Spectroscopy Study

et al. 2008

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Migraine with aura (MA) is associated with changes in cerebral blood flow (CBF), whereas the role of cerebral autoregulation is uncertain. This study aimed to evaluate basal CBF, cerebral blood volume (CBV) and vasomotor reactivity (VMR) in MA patients. Twenty-one controls and 16 MA patients (eight with side predominance) underwent simultaneous examination of flow velocity in the middle cerebral arteries by transcranial Doppler (TCD) and of near-infrared spectroscopy (NIRS) parameters [oxygen haemoglobin saturation: oxygen%, and total haemoglobin content (THC)] at rest and after hypercapnia. Cerebral VMR, THC and oxygen% increases were significantly greater on the predominant compared with the non-predominant migraine side, with both sides of patients without side predominance and with controls. These findings suggest altered autoregulation in MA patients, possibly secondary to impaired cerebrovascular autonomic control. Simultaneous TCD and NIRS investigation could represent a non-invasive approach to evaluate cerebral haemodynamics at the cortical and subcortical level.

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“…24 Using spontaneous ABP oscillations in 22 migraine patients (12 with MA), others found clearly pathological phase values in migraine patients in the MCA, both in MO and MA. 25 This led to the assumption of a neurogenic disturbance of the autoregulatory mechanism because of migraine-associated autonomic dysfunction. We could not confirm these results and found phase, gain, and Dx in the MCA to be unchanged between persons with and without migraine.…”

Section: Previous Studies On Migraine and Autoregulationmentioning

confidence: 99%

Cerebellar and Cerebral Autoregulation in Migraine

Reinhard

Schork

Allignol

et al. 2012

Stroke

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Background and Purpose-Silent ischemic brain lesions frequently occur in migraine with aura and are most often located in cerebellar border zones. This may imply an impairment of cerebellar blood flow autoregulation. This study investigated the characteristics of interictal cerebellar autoregulation in migraine with and without aura. Methods-Thirty-four patients (nϭ17, migraine without aura; nϭ17, migraine with aura) and 35 age-and sex-matched controls were studied. Triple simultaneous transcranial Doppler monitoring of one posterior inferior cerebellar artery, right posterior cerebral artery, and left middle cerebral artery was performed. Autoregulation dynamics were assessed from spontaneous blood pressure fluctuations (correlation coefficient index Dx) and from respiratory-induced 0.1-Hz blood pressure oscillations (phase and gain). Results-Compared with controls, the autoregulatory index Dx was higher (indicating less autoregulation) in the posterior inferior cerebellar artery (Pϭ0.0062) and middle cerebral artery (Pϭ0.0078) in migraine with aura, but not in migraine without aura. Phase and gain did not significantly differ between migraine patients and controls. No significant associations of autoregulation with clinical factors were found, including frequency of migraine attacks and orthostatic intolerance. Conclusions-This

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The Linear Behavior of the System Middle Cerebral Artery Flow Velocity and Blood Pressure in Patients With Migraine

Cited by 37 publications

References 23 publications

Compromised Dynamic Cerebral Autoregulation in Patients with a Right-to-Left Shunt: A Potential Mechanism of Migraine and Cryptogenic Stroke

Compromised Dynamic Cerebral Autoregulation in Patients with a Right-to-Left Shunt: A Potential Mechanism of Migraine and Cryptogenic Stroke

Increased Cerebral Vasomotor Reactivity in Migraine With Aura: An Autoregulation Disorder? A Transcranial Doppler and Near-Infrared Spectroscopy Study

Cerebellar and Cerebral Autoregulation in Migraine

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