The Link between Brain Infarction and the Gut Microbiome —— Brain-Gut Axis

Abstract

Along with research going deep, a bidirectional microbial-gut-brain axis has been found between the brain and gut microbiota, it involves many biological networks such as neural network, neuroendocrine system, immune system and metabolic pathway. Stroke is a high incidence disease in the world, with a high mortality and disability rate. The injury mechanism of ischemic stroke is complex, including calcium overload in nerve cells, cytotoxic effect of excitatory amino acids, free radical and reperfusion injury, nerve cell apoptosis, etc. The current research hotspots have been in-depth into the molecular level, signaling pathway research and targeted therapy [1]. Further understanding of microbialgut-brain axis can provide more positive help for the prevention, treatment and prognosis of ischemic stroke.