The link between hepatitis C virus and diabetes mellitus: Improvement in insulin resistance after eradication of hepatitis C virus

Hum, Justine; Jou, Janice H.

doi:10.1002/cld.694

Cited by 24 publications

(36 citation statements)

References 13 publications

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“…The proteins secreted by adipose tissue such as leptin and adiponectin assist in the regulation of glycometabolism, lipometabolism, and energetic metabolism [30,53]. Also, the particular adiponectin could improve insulin sensitivity.…”

Section: The Probable Mechanismsmentioning

confidence: 99%

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Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Zhao

Xing

Wang

et al. 2019

Journal of Diabetes Research

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Diabetes mellitus (DM) is a common chronic disease affecting humans globally. During the last few years, the incidence of diabetes has increased and has received more attention. In addition to growing DM populations, DM complications are involving injuries to more organs, such as the heart and cerebral vessel damage. DM complications can reduce quality of life and shorten life spans and eventually also impede social and economic development. Therefore, effective measures to curb the occurrence and development of diabetes assist in improving patients’ quality of life, delay the progression of DM in the population, and ease a social burden. The liver is regarded as an important link in the management and control of DM, including the alleviation of glucose metabolism and lipid metabolism and others via glucose storage and endogenous glucose generation from glycogen stored in the liver. Liver cirrhosis is a very common chronic disease, which often lowers the quality of life and decreases life expectancy. According to a growing body of research, diabetes shows a close correlation with hepatitis, liver cirrhosis, and liver cancer. Moreover, coexistence of liver complications would accelerate the deterioration of patients with diabetes. Liver cirrhosis and diabetes influence each other. Thus, in addition to pharmacological treatments and lifestyle interventions, effective control of cirrhosis might assist in a better management of diabetes. When it comes to different etiologies of liver cirrhosis, different therapeutic methods, such as antiviral treatment, may be more effective. Effective control of cirrhosis might be a strategy for better management of diabetes.

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Section: The Probable Mechanismsmentioning

confidence: 99%

“…Also, the particular adiponectin could improve insulin sensitivity. Upregulated secretion of tumor necrosis factor-α (TNF-α), and enhancive suppressor of cytokine signaling 3 (SOCS3) [53] lead to increased expression of ROS and other proinflammatory cytokines, affecting insulin signaling and cell dysfunction [54].…”

Section: The Probable Mechanismsmentioning

confidence: 99%

Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Zhao

Xing

Wang

et al. 2019

Journal of Diabetes Research

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“…The relationship between hepatitis C virus and T2DM has been well documented (1). Among patients at risk for T2DM with HCV, there is an 11-fold higher incidence of T2DM (2).…”

Section: Discussionmentioning

confidence: 99%

Replacing Insulin with Anti-Virals: A Clinical Vignette on Diabetes and HCV Treatment

Lorigiano

Sulkowski

Mixter

2020

AACE Clinical Case Reports

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Objective: There is growing evidence to support a connection between type 2 diabetes mellitus (T2DM) and chronic hepatitis C virus (HCV). Patients with hepatitis C have a substantially higher risk for developing type 2 diabetes and recently there have been several proposed mechanisms. Several retrospective studies have demonstrated a small but significant improvement in glycemic control after treatment of underlying hepatitis C virus. We describe a case that demonstrates the greatest recorded improvement in glycemic control after treatment of HCV in the setting of self-discontinuation of insulin therapy without behavioral modification. Methods: A 38-year-old obese female with uncontrolled T2DM (hemoglobin A1c [HbA1c] of 11.6% [103 mmol/mol]) was temporarily lost to follow-up and reported nonadherence to insulin therapy, metformin therapy, diet, or exercise. During this time, she was successfully treated for hepatitis C and became euglycemic without other interventions. Results: The patient's HbA1c decreased from 11.6 to 5.7% (103 to 39 mmol/mol) in the presence of weight gain and in the absence of any intervention other than hepatitis C treatment. Conclusion: Hepatitis C treatment may offer significant potential for improving insulin sensitivity and decreasing long-term complications of type 2 diabetes in certain patients. Universal treatment of HCV could offer benefits in both hepatic and extrahepatic clinical outcomes.

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“…In turn, this may help explain increased cardiovascular morbidity and mortality, (4) and virological cure results in diminished insulin resistance and progression to DM. (5) In HCV-infected LT recipients, the prevalence of DM is significantly increased compared with the noninfected, contributing to posttransplant metabolic syndrome and associated with accelerated fibrosis progression and impaired graft function. (6) In this issue of Liver Transplantation, 2 articles demonstrate that HCV cure ameliorates comorbidities after LT. Beig et al 7 report a retrospective singlecenter analysis of HCV-related LT patients treated with interferon (IFN)-free DAA regimens with metabolic profiles assessed at baseline and sustained virological response (SVR).…”

Section: See Articles On Pages 1031 and 1040mentioning

confidence: 99%

“…The mechanisms of this association are complex; they include direct viral effects, insulin resistance, and the dysregulation of cytokine cascades. In turn, this may help explain increased cardiovascular morbidity and mortality, and virological cure results in diminished insulin resistance and progression to DM . In HCV‐infected LT recipients, the prevalence of DM is significantly increased compared with the noninfected, contributing to posttransplant metabolic syndrome and associated with accelerated fibrosis progression and impaired graft function …”

mentioning

confidence: 99%

Achieving Cure From Hepatitis C Virus Is Good for More Than Just the Liver Graft

Agarwal

Brown

2018

Liver Transpl

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The link between hepatitis C virus and diabetes mellitus: Improvement in insulin resistance after eradication of hepatitis C virus

Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/11-3-reading-jou a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/11-3-interview-jou the interview with the author

Cited by 24 publications

References 13 publications

Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Replacing Insulin with Anti-Virals: A Clinical Vignette on Diabetes and HCV Treatment

Achieving Cure From Hepatitis C Virus Is Good for More Than Just the Liver Graft

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