The link between parental psychological control, depressive symptoms and epigenetic changes in the glucocorticoid receptor gene (NR3C1)

Chubar, Viktoria; Luyten, Patrick; Goossens, Luc; Bekaert, Bram; Bleys, Dries; Soenens, Bart; Claes, Stephan

doi:10.1016/j.physbeh.2020.113170

Cited by 5 publications

(2 citation statements)

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“…In addition, the onset of MDD in co-twins was reported to be much earlier in monozygotic twins ( Glowinski et al, 2003 ). In addition, clinical and preclinical studies have disclosed the association of depressive symptoms in fathers or mothers with depressive symptoms in their adolescent offspring, suggesting genetic transmission from parent to offspring ( Chubar et al, 2020 ). Taken together, these findings show that genetic factors are important risk factors for adolescent depression.…”

Section: Risk Factors For Adolescent Major Depressive Disordermentioning

confidence: 99%

Depression in Adolescence and Brain-Derived Neurotrophic Factor

Lee

Shin²,

Song³

et al. 2022

Front. Mol. Neurosci.

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The incidence of depression among adolescents has been rapidly increasing in recent years. Environmental and genetic factors have been identified as important risk factors for adolescent depression. However, the mechanisms underlying the development of adolescent depression that are triggered by these risk factors are not well understood. Clinical and preclinical studies have focused more on adult depression, and differences in depressive symptoms between adolescents and adults make it difficult to adequately diagnose and treat adolescent depression. Brain-derived neurotrophic factor (BDNF) is known to play a critical role in the pathophysiology of many psychiatric disorders, including depression. However, there are still few studies on adolescent depression. Therefore, in this review paper, the causes and treatment of adolescent depression and the function of BDNF are investigated.

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Section: Risk Factors For Adolescent Major Depressive Disordermentioning

confidence: 99%

Depression in Adolescence and Brain-Derived Neurotrophic Factor

Lee

Shin²,

Song³

et al. 2022

Front. Mol. Neurosci.

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“…In children and adolescents, the few published studies have inconsistent results. In one study, NR3C1 methylation moderated the effect of maternal support during stress on anxious attachment 18 months later (Bosmans et al., 2018), but other recent work found no association between parental psychological control and NR3C1 methylation (Chubar et al., 2020). In both samples, participants were school‐aged and adolescents, and there has been no work in the preschool age range.…”

Section: Introductionmentioning

confidence: 95%

Examining the biological impacts of parent–child relationship dynamics on preschool‐aged children who have experienced adversity

Coe,

Daniels,

Huffhines

et al. 2024

Developmental Psychobiology

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Parent–child relationship dynamics have been shown to predict socioemotional and behavioral outcomes for children, but little is known about how they may affect biological development. The aim of this study was to test if observational assessments of parent–child relationship dynamics (cohesion, enmeshment, and disengagement) were associated with three biological indices of early life adversity and downstream health risk: (1) methylation of the glucocorticoid receptor gene (NR3C1), (2) telomere attrition, and (3) mitochondrial biogenesis, indexed by mitochondrial deoxyribonucleic acid (DNA) copy number (mtDNAcn), all of which were measured in children's saliva. We tested hypotheses using a sample of 254 preschool‐aged children (M age = 51.04 months) with and without child welfare‐substantiated maltreatment (52% with documented case of moderate‐severe maltreatment) who were racially and ethnically diverse (17% Black, 40% White, 23% biracial, and 20% other races; 45% Hispanic) and from primarily low‐income backgrounds (91% qualified for public assistance). Results of path analyses revealed that: (1) higher parent–child cohesion was associated with lower levels of methylation of NR3C1 exon 1D and longer telomeres, and (2) higher parent–child disengagement was associated with higher levels of methylation of NR3C1 exon 1D and shorter telomeres. Results suggest that parent–child relationship dynamics may have distinct biological effects on children.

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