The link between thyroid autoimmunity, depression and bipolar disorder

Jucevičiūtė, Neringa; Žilaitienė, Birutė; Aniulienė, Rosita; Vanagienė, Virginija

doi:10.1515/med-2019-0008

Cited by 21 publications

(17 citation statements)

References 49 publications

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“…Treatment-resistant MDD, increased severity of MDD, psychotic phenomenology, and somatic symptoms are all possible consequences of this comorbidity [ 24 ]. Patients with MDD may have immune system activation, which can develop into autoimmune thyroiditis and thyroid dysfunction [ 25 ]. Thyroid hormone replacement therapy has been shown to benefit individuals with hypothyroidism and MDD, particularly treatment-resistant patients or/and those with unusual symptoms [ 24 ].…”

Section: Reviewmentioning

confidence: 99%

Hypothyroidism and Depression: A Narrative Review

Nuguru¹,

Rachakonda²,

Sripathi³

et al. 2022

Cureus

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There has been an established relationship between hypothyroidism and depression. Studies have demonstrated that somatostatin and serotonin influence the hypothalamus-pituitary-thyroid axis, which links hypothyroidism to depression. Multiple studies concluded that undiagnosed, untreated, undertreated patients with hypothyroidism are at increased risk of developing depression. Autoimmune thyroiditis is also associated with an increased risk of depression. Elevated thyroid-stimulating hormone (TSH), antithyroglobulin (TgAb), and thyroid peroxidase antibodies (TPOAb) levels have all been linked to depression and an increased risk of suicide. Moreover, hypothyroidism is known to be one of the leading causes of treatment-resistant depression. Treating underlying hypothyroidism with thyroid replacement therapy could significantly improve mood disorders such as depression. Levothyroxine therapy is also used as adjunctive therapy to antidepressants in the management of depression, and it is known to improve the symptoms of depression rapidly when compared to antidepressants alone. This review strengthens the link between hypothyroidism and depression, and it also demonstrates how treating the underlying hypothyroidism in people who have been diagnosed with depression will be very beneficial.

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Section: Reviewmentioning

confidence: 99%

Hypothyroidism and Depression: A Narrative Review

Nuguru¹,

Rachakonda²,

Sripathi³

et al. 2022

Cureus

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“…Треба зазначити, що отримані авторами дані щодо особливостей психоемоційного стану жінок з неонкологічними захворюваннями ЩЗ, а саме, наявності у них переважно клінічно виражених (або донозологічних) тривожних, депресивних і астенічних феноменів, що мали нозоспецифічну вираженість в залежності від виду тиреопатії, співпадають з результатами інших дослідників [3,4,[7][8][9][12][13][14][15].…”

Section: результати та їх обговоренняunclassified

Features of Formation and Target-Differentiated Psychocorrection of Psychological Maladaptation in Women With Non-Cancer Thyroid Disease

Markova

Fedak

Varybrus

et al. 2019

PEP

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* Дослідження виконано в межах наукової тематики Харківської медичної академії післядипломної освіти МОЗ України «Порушення здоров'я сім'ї у кризових станах різного ґенезу. Причини, механізми розвитку, клінічні прояви і система психодіагностики, психокорекції, психопрофілактики» (номер державної реєстрації 0112U000972) та «Медико-психологічні наслідки соціального стресу та інформаційно-психологічної війни (макро-, мікросоціальні чинники дезадаптації, механізми формування, система психодіагностики, психокорекції, психопрофілактики)» (номер державної реєстрації 0117U000371). Установою, що фінансує дослідження, є МОЗ України. Автори гарантують повну відповідальність за все, що опубліковано в статті. Автори гарантують відсутність конфлікту інтересів і власної фінансової зацікавленості при виконанні роботи та написанні статті. Рукопис надійшов до редакції 25.03.2019.

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“…Postoje dokazi da disfunkcija imunološkog sistema smanjuje sinaptičku dostupnost monoamina [9,10,19].…”

Section: Diskusijaunclassified

“…Razvoj postpartalne depresije dovodi se u vezu sa povišenim vrijednostima antitijela na tiroidnu peroksidazu u tokom trudnoće, ali ne i nakon porođaja. Samim tim, rutinski skrining u trudnoći mogao bi rezultovati prevencijom postpartalne depresije [19,20].…”

Section: Diskusijaunclassified

Postpartal depression and thyroid disorders

Jandrić-Kočić¹

2019

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Introduction: Postpartum depression negatively affects a woman's quality of life and the development of a relationship with her child, which can have far-reaching consequences on the cognitive, behavioral and emotional development of the child. Etiology includes genetic predisposition, sudden hormonal changes, and sociodemographic factors. Case report: A 28-year-old patient, married, mother of a one-month-old boy. She graduated from the High school of economics, unemployed. She appears in the family medicine clinic due to chronic fatigue and bad mood, at the insistence of her husband, who thinks that she needs professional help. She grew up in a harmonious family. He gets along well with his wife, there are no existential problems. It denies previous illnesses. Neat appearance, inconspicuous posture and behavior, psychomotor diskette slowed down, more sparse spontaneous verbalization, slightly compromised volitional instinctual dynamisms, lowered basic mood. In the laboratory findings, hypothyroidism with elevated thyroid peroxidase antibody and antithyreoglobulin antibodies is detected. The thyroid ultrasound verifies the right lobe of 46x14x15mm, the left lobe of 48x13x12mm, inhomogeneous and easily hypoechoic structure. The Edinburgh Postnatal Depression Scale indicates the presence of depression (total score 18). The patient is referred for a consultative examination by a psychiatrist and a nuclear medicine specialist. Psychiatrist indicates the introduction of Sertralin 50 mg tablets (1x1/2 for the first seven days, then 1x1) and Bromasepam tablets 1,5 mg (2x1/2), nuclear specialist Levotiroskin sodium tablets 50 mcg (1x1/2 for 5 days and 1x1 for 2 days). After six months, withdrawal of the symptoms of the disease and exclusion of therapy by a psychiatrist. Conclusion: Autoimmune thyroid disease is a significant and often unrecognized cause of postpartum depression. Early detection and timely therapeutic intervention of these have a significant role in the prevention and successful treatment of postpartum depression.

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The link between thyroid autoimmunity, depression and bipolar disorder

Cited by 21 publications

References 49 publications

Hypothyroidism and Depression: A Narrative Review

Hypothyroidism and Depression: A Narrative Review

Features of Formation and Target-Differentiated Psychocorrection of Psychological Maladaptation in Women With Non-Cancer Thyroid Disease

Postpartal depression and thyroid disorders

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