The Link Of Epstein Barr Virus Infection And Rheumatoid Arthritis Immunopathogenesis

Masdar, Huriatul

doi:10.26891/jik.v4i2.2010.79-88

Cited by 2 publications

(2 citation statements)

References 68 publications

(50 reference statements)

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“…This result is similar to other studies that demonstrated a link between EBV infection and RA pathogenesis. [16][17][18][19] One of the chronic autoantibody responses related to the development of RA is the anti-EBV antibody response. 20 Other studies have provided evidence about the association of EBV with RA, and have shown EBV to be the cause of RA.…”

Section: Discussionmentioning

confidence: 99%

Epstein–Barr Virus and Rheumatoid Arthritis in Cancer Patients Undergoing Chemotherapy in Al-Najaf Province, Iraq

Talib Al-Nafakh

2024

JCD

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Background: Some studies suggested a link between Epstein-Barr Virus (EBV) and rheumatoid arthritis, although the exact mechanism of this is not yet established. Cancer patients undergoing chemotherapy are more immunocompromised. Hence this study has demonstrated the role of EBV in rheumatoid arthritis in these patients.Objective: To study the relationship between Epstein-Bar viral infection and rheumatoid arthritis in cancer patients undergoing chemotherapy Patients and Methods: A cross-sectional study was conducted from September 1, 2021 to March 1, 2022. The study participants included 200 cancer patients who reported to the Middle Euphrates Cancer Center in Al Najaf for chemotherapy treatment. Cancer patients were diagnosed with cases of rheumatoid arthritis, according to rheumatologist physicians and serological tests. Five ml of blood was collected from every cancer patient. Each sample was screened for the presence of anti-EBV antibodies. The chi-square test was used to test the significance of the relationship between qualitative variables. A p value of less than or equal to 0.05 indicated a statistically significant difference.Results: Two hundred cancer patients were included in this study. Their age ranged from 17 to 73 years. Nearly half of them (47.5%) aged 30-50 years. Most of them were females (67.0%) and 60.5% of the participants lived in urban areas. More than one-third of participants (40.0%) had rheumatoid arthritis. More than half of them (53.0%) were EBV-positive. Statistical analysis showed a highly significant association between EBV and rheumatoid arthritis (p < 0.00001). No significant differences (p > 0.05) were found between different age groups regarding anti-EBV-IgM and IgG antibodies in rheumatoid and non-rheumatoid patients. On the other hand, PCR testing showed a statistically significant difference (p < 0.001) in non-rheumatoid patients and no significant difference in rheumatoid patients. Conclusion:A significant association was detected between EBV and rheumatoid arthritis in cancer patients treated by chemotherapy and this association was not related to EBV antibody levels.

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Section: Discussionmentioning

confidence: 99%

Epstein–Barr Virus and Rheumatoid Arthritis in Cancer Patients Undergoing Chemotherapy in Al-Najaf Province, Iraq

Talib Al-Nafakh

2024

JCD

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“…Several studies speculated that EBV infection is strongly associated with RA from different parts of the world [ 7 , 10 , 11 ]. In Pakistan, EBV has been detected in various lymphoma patients from different areas [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Frequency and association of Epstein-Barr Virus genotype in rheumatoid arthritis patients of Khyber Pakhtunkhwa, Pakistan

Munir,

Khan,

Khan

et al. 2023

PLoS ONE

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Background Rheumatoid arthritis (RA) is an immune-mediated, polyarthritis linked with various genetic and environmental causative agents. Among environmental triggers, Epstein-Barr Virus (EBV) is considered the most potent etiological agent. Objective This study aimed to investigate the prevalence of EBV and its genotypes in RA patients and to investigate their association with clinical and laboratory parameters of RA. Methodology This study included blood samples of RA and control healthy individuals (100 each). Blood samples along with clinical and laboratory parameters were collected from patients after consent in the Department of Rheumatology, at Lady Reading Hospital, in Peshawar Pakistan. Blood samples were processed for DNA extraction followed by PCR amplification for EBV detection and genotype discrimination. Results RA patients were 85 females and 15 males with a mean age of 40.13±14.05 years. EBV Type-1 was detected in 45% of RA and 9% of control cases. The mean disease duration of RA patients was 6.61±6.23 years. Out of 100 diseased patients, 43% were seropositive rheumatoid arthritis (SPRA) and showed a significant correlation with a family history of RA in EBV-positive individuals (P = 0.017). The demographic, clinical, and laboratory parameters of RA patients showed a non-significant association with EBV. Moreover, only a family history and Serum creatinine of RA patients showed a significant association with EBV (P = 0.0001 and P = 0.022 respectively). Conclusion It is concluded that EBV-1 is prevalent and associated with RA. Further investigation is required for detailed genetic analysis of EBV to determine its possible role in modulating the immune system in RA.

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The Link Of Epstein Barr Virus Infection And Rheumatoid Arthritis Immunopathogenesis

Cited by 2 publications

References 68 publications

Epstein–Barr Virus and Rheumatoid Arthritis in Cancer Patients Undergoing Chemotherapy in Al-Najaf Province, Iraq

Epstein–Barr Virus and Rheumatoid Arthritis in Cancer Patients Undergoing Chemotherapy in Al-Najaf Province, Iraq

Frequency and association of Epstein-Barr Virus genotype in rheumatoid arthritis patients of Khyber Pakhtunkhwa, Pakistan

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