The Lipid Handbook with CD-ROM

Harwood, John L.; Gunstone, Frank D.; Dijkstra, Albert J.

doi:10.1201/9781420009675

Cited by 300 publications

(339 citation statements)

References 149 publications

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“…1 Meat and milk of ruminants are the well known exceptions that contain a few percent of trans lipids produced by biohydrogenation during the process of rumination. 1 The cis configuration is known to increase the flexibility of lipid membranes, while the trans makes them stiff. Recently, health risks such as coronary heart disease (CHD) caused by trans lipids contained in food have been pointed out by medical researches.…”

Section: Introductionmentioning

confidence: 99%

High concentration trans form unsaturated lipids detected in a HeLa cell by Raman microspectroscopy

Onogi

Motoyama

Hamaguchi

2008

J Raman Spectroscopy

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High concentration trans form unsaturated lipids have been found in a HeLa cell by Raman microspectroscopy. Two C C stretch bands are observed simultaneously at 1669 cm −1 (trans form) and at 1656 cm −1 (cis form) in a Raman spectrum obtained from a small area (1 µm in diameter) in a HeLa cell. The intensity ratio 1669/1656 indicates that the concentration of the trans form is as high as that of the cis. It is demonstrated that Raman microspectroscopy provides a powerful and unique means for in situ and noninvasive structural characterization of unsaturated lipids in a living cell.

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Section: Introductionmentioning

confidence: 99%

High concentration trans form unsaturated lipids detected in a HeLa cell by Raman microspectroscopy

Onogi

Motoyama

Hamaguchi

2008

J Raman Spectroscopy

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“…Actually, hydrolysis forms MAG and DAG which are known for their emulsifying properties. The hydrophilic/lipophilic balance of partial acylglycerols is function of the chain length of FA esterified on the glycerol [22]. MAG and DAG resulting from the hydrolysis of trilaurin (12-MAG and 12-DAG) have a better hydrophilic/hydrophobic balance than MAG and DAG resulting from hydrolysis of triolein (18-MAG and 18-DAG).…”

Section: Lipase Selectivity Evaluationmentioning

confidence: 99%

Evaluation of Rhizopus oryzae Lipase for the Determination of Regiodistribution in Triacylglycerols with Medium Chain Fatty Acids

Pérignon¹,

Lecomte²,

Pina³

et al. 2011

J Americ Oil Chem Soc

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The nutritional profile and rheological behaviors of lipids is both due to fatty acid composition and regiodistribution on external and internal positions of triacylglycerol. Actual methods for regiodistribution analysis having some restrictions, there is still a need for investigating a safe, simple and environmentally friendly method for the sn-2 position analysis that could especially be used for the analysis of fats containing medium and short chain fatty acids. The objective of this study was to evaluate the 1,3-selectivity and typoselectivity of Rhizopus oryzae lipase in the presence of short/medium chain fatty acids in partial hydrolysis conditions used for regiodistribution analysis. Structured triacylglycerols containing eightcarbon-chain length fatty acids in the sn-2 position were chemically synthesized using DCC/DMAP coupling agent and purification steps by flash-chromatography. The final product showed very high purity and was used as the substrate for 1,3-selectivity evaluation. Typoselectivity was assessed by investigating partial hydrolysis of equimolar blends of homogeneous TAG. This study confirmed the 1,3-selectivity of Rhizopus oryzae lipase in the hydrolysis conditions used, and revealed that this lipase was less influenced by fatty acids chain length than pancreatic lipase. Considering this, Rhizopus oryzae lipase appeared to be a good candidate for regiodistribution analysis of fats containing medium and short chain fatty acids.

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“…Both types of PUFA are needed in a healthy diet [1] but there has been a continuous debate about the amounts and the ratio of n-3/n-6 PUFA which are required [2]. Although the plant-derived PUFA, linoleate and a-linolenate, are the main dietary components it is their 20C metabolites, arachidonate (ARA) and eicosapentaenoate (EPA), respectively, which are the direct precursors of the biologically-active eicosanoids.…”

Section: Introductionmentioning

confidence: 99%

Contrasting Effects of n‐3 and n‐6 Fatty Acids on Cyclooxygenase‐2 in Model Systems for Arthritis

Hurst

Rees

Randerson

et al. 2009

Lipids

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Cyclooxygenase-2 (COX-2) is intimately involved in symptoms of arthritis while dietary n-3 polyunsaturated fatty acids (PUFA) are thought to be beneficial. In these experiments, using both bovine and human in vitro systems that mimic features of arthritis, we show that the n-3 PUFA eicosapentaenoic acid (EPA) is able to reduce mRNA and protein levels of COX-2. Activity, as assessed through prostaglandin E(2) formation, was also reduced in a dose-dependent manner. These effects of EPA contrasted noticeably with the n-6 PUFA, arachidonic acid. The data provide direct evidence for a molecular mechanism by which dietary n-3 PUFA, such as EPA, can reduce inflammation and, hence, associated symptoms in arthritis.

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The Lipid Handbook with CD-ROM

Cited by 300 publications

References 149 publications

High concentration trans form unsaturated lipids detected in a HeLa cell by Raman microspectroscopy

High concentration trans form unsaturated lipids detected in a HeLa cell by Raman microspectroscopy

Evaluation of Rhizopus oryzae Lipase for the Determination of Regiodistribution in Triacylglycerols with Medium Chain Fatty Acids

Contrasting Effects of n‐3 and n‐6 Fatty Acids on Cyclooxygenase‐2 in Model Systems for Arthritis

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