The lipid-mediated hypothesis of fumonisin B1 toxicodynamics tested in model membranes

Theumer, Martín G.; Clop, Eduardo M.; Rubinstein, H.R.; Perillo, Marı́a A.

doi:10.1016/j.colsurfb.2008.01.002

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…Use of physicochemical techniques to investigate the interaction of a range of molecules with model membranes (particularly Langmuir films and vesicles) is becoming a fertile area of study. For example, the effects of lipoplexes,28, 29 biosurfactants,30 biopolymers and proteins,31–33, designer peptides34, 35 bile salts36 and cholesterol37–39 on the membrane structure. Several of these studies have focused on mixtures of lipids,29, 36, 37, 40 ,42 but to date few studies have attempted to recreate the complexity of biological membranes (e.g., using red blood cell lipids [41] ) and to the authors knowledge none have tried to make models relating to endocytic vesicles.…”

Section: Resultsmentioning

confidence: 99%

Interaction of an Endosomolytic Polyamidoamine ISA23 with Vesicles Mimicking Intracellular Membranes: A SANS/EPR Study

Griffiths

Nilmini

Carter

et al. 2010

Macromolecular Bioscience

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The mechanism of ISA23 · HCl interaction with model membrane vesicles (80-100 nm in diameter) was investigated using EPR in conjunction with SANS. For EPR, 16-DSE was dissolved in the vesicle membrane to measure its dynamics and polarity, whereas a spin-labeled (Tempo)-ISA 23 analogue was used to give a measure of the polymer flexibility. When ISA23 was added to the external vesicle surface, no interaction was found. This observation conflicts with the reported ability to lyse RBC, but is in agreement with recent studies that showed no effect on membrane permeability when a PAA was added to an incubation medium containing isolated lysosomal vesicles. The vesicle-mimetic models used here provide a new and useful tool for studying endosomolytic polymer/membrane interactions.

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Section: Resultsmentioning

confidence: 99%

Interaction of an Endosomolytic Polyamidoamine ISA23 with Vesicles Mimicking Intracellular Membranes: A SANS/EPR Study

Griffiths

Nilmini

Carter

et al. 2010

Macromolecular Bioscience

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“…As to FB1, toxicity has indeed been associated with detrimental effects on lipid metabolism, including effects on phospholipids and fatty acids, yielding patterns closely resembling those found in hepatocyte nodules obtained with cancer initiation/promotion models (Gelderblom et al., ; Howard et al., ; Gelderblom, Moritz, Swanevelder, Smuts, & Abel, ; Riedel, Abel, Swanevelder, & Gelderblom, ; Riedel et al., ). Alterations in lipid composition and stable interactions of FB1 with polar head groups of membrane lipids could modify basic membrane characteristics such as membrane permeability and fluidity, as well as induce structural changes in biomembranes (Abel, Smuts, De Villiers, & Gelderblom, ; Gelderblom et al., ; Burger, Abel, Snijman, Swanevelder, & Gelderblom, ; Theumer, Clop, Rubinstein, & Perillo, ; Riedel et al., ). Specific conditions beneficial for the clonal expansion of initiated cells could emerge that simultaneously inhibit the proliferation of non‐initiated surrounding cells (Farber, ; Laconi, Pani, & Farber, ; Gelderblom et al., ; Riedel et al., ).…”

Section: Mechanisms Of Action Of Fumonisinsmentioning

confidence: 99%

Exposure, Occurrence, and Chemistry of Fumonisins and their Cryptic Derivatives

Braun

Wink

2018

Comp Rev Food Sci Food Safe

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Fumonisins are mycotoxins mainly produced by Fusarium proliferatum and Fusarium verticillioides. Because of their wide distribution, the potential health hazard, and economic significance, they are considered one of the most important mycotoxin classes. Epidemiological evidence suggests a relationship between the Fusarium load in corn, exposure to fumonisins, and esophageal cancer. However, mechanisms of actions of fumonisins are not yet fully resolved and epidemiological studies suffer from various confounding factors. Correspondingly, the most relevant congener of the fumonisin family (fumonisin B 1 ) has been classified as possibly carcinogenic to humans and maximum limits have been set for corn and corn-based products. However, many non-corn-based products are also susceptible to fumonisin contamination. Indeed, some of them contain very high amounts of fumonisins, but enter the market legally. Furthermore, fumonisin exposure of consumers is probably consistently being underestimated because only a fraction of fumonisins can be detected by routine analysis. The bioavailability and toxicity of most nondetectable (cryptic) forms has not been resolved. In this work, we review the developments of cancer research into fumonisins since their discovery in 1988 until today and provide an overview of the contributions of various foodstuffs to fumonisin exposure, including those products that have been largely neglected in the past. In conclusion, (1) corn remains the principal source of fumonisin ingestion, but fumonisins in non-corn-based commodities require continuous monitoring;(2) cryptic fumonisins should be included in risk assessment studies; and (3) certain population groups (for example children) may suffer from enhanced exposure and could face increased health risks.

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“…Fumonisins are toxic metabolites produced predominantly by Fusarium verticillioides , one of the most common molds present globally on maize and other agricultural products (1–3). Areas of low and high esophageal cancer incidence in the former Transkei region of South Africa have been shown to correlate with low and high levels of fumonisin-contaminated home-grown maize, respectively (4).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of the proliferation of human normal esophageal epithelial cells by fumonisin B1 and its mechanism

Wang

Huang

et al. 2013

Experimental and Therapeutic Medicine

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Previous epidemiological studies have demonstrated a correlation between fumonisin B1 (FB1) and human esophageal cancer in China, Iran and South Africa. The purpose of this study was to investigate the effects of FB1 on the proliferation, cell-cycle and apoptosis of normal human esophageal epithelial cells (HEECs) and to explore the molecular mechanisms of these effects. The proliferation of HEECs treated with FB1 was assessed using a colorimetric assay, while analyses of the cell cycle and apoptosis were performed using flow cytometry and the measurement of the protein expressions of genes associated with the cell cycle was conducted using western blotting. The results showed that FB1 stimulated the proliferation of HEECs, decreased the percentage of cells in the G0/G1 phase and reduced apoptosis. The western blotting results showed that FB1 significantly increased the protein expression of cyclin D1 and significantly decreased the protein expression of cyclin E, p21 and p27. The results indicated that FB1 stimulated the proliferation of HEECs by affecting the cell cycle and apoptosis. This mechanism was associated with changes in cyclin D1, cyclin E, p21 and p27 expression.

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The lipid-mediated hypothesis of fumonisin B1 toxicodynamics tested in model membranes

Cited by 13 publications

References 43 publications

Interaction of an Endosomolytic Polyamidoamine ISA23 with Vesicles Mimicking Intracellular Membranes: A SANS/EPR Study

Interaction of an Endosomolytic Polyamidoamine ISA23 with Vesicles Mimicking Intracellular Membranes: A SANS/EPR Study

Exposure, Occurrence, and Chemistry of Fumonisins and their Cryptic Derivatives

Stimulation of the proliferation of human normal esophageal epithelial cells by fumonisin B1 and its mechanism

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