The lipid profile in obese asthmatic children compared to non-obese asthmatic children

Fang, Li-Jung; Huang, Che-Sheng; Liu, Y.-C.; Su, Yu-Mao; Wan, Kong‐Sang

doi:10.1016/j.aller.2015.12.004

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…Results of a number of studies have also linked elevated lipid levels with the development of asthma/wheezing in children and adults (1,2,3,4,5,16). However, the results are inconsistent with those of other studies that show no association (12,13,17), or even a negative association, between elevated lipids and asthma/wheezing (11). The reported associations between asthma and lipid levels and insulin resistance (IR) appear to be independent of body mass index (BMI) (3).…”

Section: Introductioncontrasting

confidence: 96%

“…The discussion of this topic would not be complete without drawing attention to studies that did not find an association between lipids and asthma. Recently, Fang et al (17) compared the lipid profiles of obese asthmatic children with those of non-obese asthmatic children. The results showed that none of the asthmatic children had hypercholesterolemia and hypertriglyceridemia and that there were no differences in apo-A1 and apo-B between any of the BMI groups, nor were there differences in LDL levels (17).…”

Section: Discussionmentioning

confidence: 99%

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No Associations Between Serum Lipid Levels or HOMA-IR and Asthma in Children and Adolescents: A NHANES Analysis

Lü

Qiao

et al. 2019

Jcrpe

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Objective:Studies have reported inconsistent results on the associations between lipids and insulin resistance (IR) and asthma. The purpose of this study was to examine the associations between abnormal serum lipid levels and homeostatic model assessment-IR (HOMA-IR) and the presence of current asthma in children and adolescents.Methods:The United States National Health and Nutrition Examination Survey database from 1999 to 2012 was randomly searched for children (aged 3-11 years) and adolescents (aged 12-19 years) with and without asthma and with complete demographic and clinical data of interest. Logistic regression analyses were performed to examine associations between abnormal serum lipids, glucose and HOMA-IR and the current presence of asthma.Results:The data of 11,662 children (3 to 11 years of age) and 12,179 adolescents (12 to 19 years of age) were included in the analysis. The study group included 3,703 participants with asthma and 20,138 participants without asthma. The prevalence of self-reported current asthma was higher among participants aged between 3-11 years (52.9%) than among those aged between 12-19 years (50.7%). Multivariate analyses, after adjusting for sex, race, income-to-poverty ratio, low birth weight, prenatal maternal smoking, tobacco exposure, C-reactive protein level and body mass index Z-score, revealed no associations between elevated fasting plasma glucose, reduced high-density lipoprotein cholesterol, elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides and HOMA-IR and the presence of current asthma in children or adolescents.Conclusion:In this cross-sectional study, no association was found between abnormal serum lipids or HOMA-IR and the presence of current asthma in children or adolescents.

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Section: Introductioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

No Associations Between Serum Lipid Levels or HOMA-IR and Asthma in Children and Adolescents: A NHANES Analysis

Lü

Qiao

et al. 2019

Jcrpe

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“…To date, the findings of the studies about the correlation between dyslipidemia and asthma are contradictory [ 82 ]. One potential explanation is represented by ethnic metabolic differences.…”

Section: Different Clinical Subtypes Of the Obese-asthmatic Phenotmentioning

confidence: 99%

Asthma and Obesity in Children

et al. 2020

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Asthma and obesity are two major chronic diseases in children and adolescents. Recent scientific evidence points out a causative role of obesity in asthma predisposition. However, studies assessing the real impact of excessive weight gain on lung function in children have shown heterogeneous results. In this review, the pathological mechanisms linking obesity and development of asthma in children are summarized and factors influencing this relationship are evaluated. Common disease modifying factors including age, sex, ethnicity, development of atopic conditions, and metabolic alterations significantly affect the onset and phenotypic characteristics of asthma. Given this, the impact of these several factors on the obesity–asthma link were considered, and from revision of the literature we suggest the possibility to define three main clinical subtypes on the basis of epidemiological data and physiological–molecular pathways: obese-asthmatic and atopy, obese-asthmatic and insulin-resistance, and obese-asthmatic and dyslipidemia. The hypothesis of the different clinical subtypes characterizing a unique phenotype might have an important impact for both future clinical management and research priorities. This might imply the necessity to study the obese asthmatic child with a “multidisciplinary approach”, evaluating the endocrinological and pneumological aspects simultaneously. This different approach might also make it possible to intervene earlier in a specific manner, possibly with a personalized and tailored treatment. Surely this hypothesis needs longitudinal and well-conducted future studies to be validated.

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“…Moreover, although Skaaby et al [32] reported that atopy was associated with reversible Westernized lifestyle-related factors, they did not note a positive association between serum TC levels and AP. Recently, Fang et al [33] enrolled 160 pediatric asthmatic patients, divided into 4 subgroups, according to their BMI. All patients also underwent lipid profile measurements including ApoA1, ApoB, TC, LDL, HDL, and TG.…”

Section: Resultsmentioning

confidence: 99%

“…However, while several literature findings suggest the role of the lipid profile in the development of atopy [9], other reports differ on the direction of the abovementioned relationship [29,30,31,32,33]. Therefore, in the light of contrasting research strategy findings, through the revision of literature data, this systematic review aims to analyze the latest data and advances on the relationship between the onset of AP and related diseases and serum cholesterol levels.…”

Section: Introductionmentioning

confidence: 99%

Association between Allergies and Hypercholesterolemia: A Systematic Review

Manti

Cuppari²,

Marseglia³

et al. 2017

Int Arch Allergy Immunol

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Background: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. Methods: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations. Information on the study design, sample, intervention, comparators, outcome, time frame, and risk of bias were abstracted for each article. Results: Of 601 reviewed reports, 18 were included in this systematic review. Fifteen studies assessed the relationship between AP and serum cholesterol levels. Due to the lack both of observational and cross-sectional studies from the literature search at this time (only 8 studies also analyzed confounding factors) there is a high possibility of confounding variables (familial and genetic predisposition, age, gender, BMI, comorbidity, and medication status) that could not be ruled out. Conclusion: Existing studies are heterogeneous, making it difficult to draw broad conclusions. Future studies and more detailed analyses, considering confounding variables and including a larger and homogeneous population, are needed to strengthen the argument for a link between lipid metabolism and atopy.

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The lipid profile in obese asthmatic children compared to non-obese asthmatic children

Cited by 7 publications

References 31 publications

No Associations Between Serum Lipid Levels or HOMA-IR and Asthma in Children and Adolescents: A NHANES Analysis

No Associations Between Serum Lipid Levels or HOMA-IR and Asthma in Children and Adolescents: A NHANES Analysis

Asthma and Obesity in Children

Association between Allergies and Hypercholesterolemia: A Systematic Review

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