The Lipids of Biological Membranes

Yèagle, Philip L.

doi:10.1016/b978-0-12-800047-2.00002-4

Cited by 31 publications

(48 citation statements)

References 6 publications

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“…A third peak is also present on the right side of the sharp peak red arrow . The position and appearance of this peak is comparable to the high-temperature shoulder arising from the presence of partially hydrated lipid molecules in DPPC containing 48 of water 35,36 . Therefore, this peak may arise due to modification of the hydration of the bilayer by PSO 4 .…”

Section: Phase Behavior and Hydration Properties Of Dspc-β-sitosterylsupporting

confidence: 50%

“…Thus, the remaining portion, i.e., the PSO 4 -poor fraction, is no longer a homogeneous gel phase coexisting with the excess free water. Instead, it exists as a mixture of an excess-watergel phase and partially hydrated lipid molecules of the kind described by Kodama et al 35 and Yeagle 36 . A schematic diagram of the modification of the hydration of the DSPC membrane by PSO 4 is depicted in Fig.…”

Section: Discussionmentioning

confidence: 99%

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Effects of <i>β</i>-Sitosteryl Sulfate on the Phase Behavior and Hydration Properties of Distearoylphosphatidylcholine: a Comparison with Dipalmitoylphosphatidylcholine

et al. 2018

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Section: Phase Behavior and Hydration Properties Of Dspc-β-sitosterylsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Effects of <i>β</i>-Sitosteryl Sulfate on the Phase Behavior and Hydration Properties of Distearoylphosphatidylcholine: a Comparison with Dipalmitoylphosphatidylcholine

et al. 2018

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“…If the interior of the cell is considered the actual place of reproduction, compartmentalization gives the appropriate environment to biological metabolic reactions and the highly selective kinetic barrier properties of the membrane regulate the exchange of matter and energy with the surroundings (Yeagle 2004).…”

Section: Introductionmentioning

confidence: 99%

Membrane Hydration: A Hint to a New Model for Biomembranes

Disalvo

2015

Subcellular Biochemistry

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The classical view of a biological membrane is based on the Singer-Nicholson mosaic fluid model in which the lipid bilayer is the structural backbone. Under this paradigm, many studies of biological processes such as, permeability, active transport, enzyme activity and adhesion and fusion processes have been rationalized considering the lipid membrane as a low dielectric slab of hydrocarbon chains with polar head groups exposed to water at each side in which oil/water partition prevails. In spite of several analyses and evidence available in relation to membrane hydration, water is not taken into account as a functional component. For this purpose, new insights in the water organization in restricted environments and the thermodynamical and mechanical properties emerging from them are specifically analysed and correlated.This chapter summarizes the progress of the studies of water in membranes along the book in order to give a more realistic structural and dynamical picture accounting for the membrane functional properties.

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“…1,2 To overcome these cellular barriers, nanocarriers, such as carbon nanotubes (CNTs), have been used widely to improve the delivery of drugs and interrogate cells due to their controlled°u id handling and displacing much less cellular materials in comparison to microcarriers. [3][4][5] In this regard, several studies have been done to investigate various aspects of the cell injection process.…”

Section: Introductionmentioning

confidence: 99%

Cellular Injection Using Carbon Nanotube: A Molecular Dynamics Study

Mahboobi

Taheri

Pishkenari

et al. 2015

NANO

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Determination of an injection condition which is minimally invasive to the cell membrane is of great importance in drug and gene delivery. For this purpose, a series of molecular dynamics (MD) simulations are conducted to study the penetration of a carbon nanotube (CNT) into a pure POPC cell membrane under various injection velocities, CNT tilt angles and chirality parameters. The simulations are nonequilibrium and all-atom. The force and stress exerted on the nanotube, deformation of the lipid bilayer, and strain of the CNT atoms are inspected during the simulations. We found that a lower nanotube velocity results in successfully entering the membrane with minimum disruption in the CNT and the lipid bilayer, and CNT's chirality distinctly a®ects the results. Moreover, it is shown that the tilt angle of the CNT in°uences the nanotube's buckling and may result in destroying the membrane structure during the injection process.

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The Lipids of Biological Membranes

Cited by 31 publications

References 6 publications

Effects of <i>β</i>-Sitosteryl Sulfate on the Phase Behavior and Hydration Properties of Distearoylphosphatidylcholine: a Comparison with Dipalmitoylphosphatidylcholine

Effects of <i>β</i>-Sitosteryl Sulfate on the Phase Behavior and Hydration Properties of Distearoylphosphatidylcholine: a Comparison with Dipalmitoylphosphatidylcholine

Membrane Hydration: A Hint to a New Model for Biomembranes

Cellular Injection Using Carbon Nanotube: A Molecular Dynamics Study

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