2013
DOI: 10.1128/cvi.00458-12
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The Live Attenuated Actinobacillus pleuropneumoniae Triple-Deletion Mutant Δ apxIC Δ apxIIC Δ apxIV - ORF1 Strain, SLW05, Immunizes Pigs against Lethal Challenge with Haemophilus parasuis

Abstract: Haemophilus parasuis and Actinobacillus pleuropneumoniae both belong to the family Pasteurellaceae and are major respiratory pathogens that cause large economic losses in the pig industry worldwide. We previously constructed an attenuated A. pleuropneumoniae serovar 1 live vaccine prototype, SLW05 (⌬apxIC ⌬apxIIC ⌬apxIV-ORF1), which is able to produce nontoxic but immunogenic ApxIA, ApxIIA, and ApxIVA. This triple-deletion mutant strain was shown to elicit protective immunity against virulent A. pleuropneumoni… Show more

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Cited by 15 publications
(8 citation statements)
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“…H.parasuis strains Nagasaki, SH0165, and 29755 are all serotype 5 strains that were initially isolated from pigs with signs of Glässer's disease, and the results reported here confirm previous experimental reports in which disease occurred in swine following intranasal infection [16], [17], [26][29]. Strains 12939 and MN-H were also initially isolated from pigs with Glässer's disease, however coinfecting agents were also identified; porcine reproductive and respiratory syndrome virus in the case of strain 12939 and porcine circovirus type 2, bovine virus diarrhea virus, Pasteurella multocida , and Arcanobacterium pyogenes in the case of strain MN-H.…”
Section: Resultssupporting
confidence: 89%
“…H.parasuis strains Nagasaki, SH0165, and 29755 are all serotype 5 strains that were initially isolated from pigs with signs of Glässer's disease, and the results reported here confirm previous experimental reports in which disease occurred in swine following intranasal infection [16], [17], [26][29]. Strains 12939 and MN-H were also initially isolated from pigs with Glässer's disease, however coinfecting agents were also identified; porcine reproductive and respiratory syndrome virus in the case of strain 12939 and porcine circovirus type 2, bovine virus diarrhea virus, Pasteurella multocida , and Arcanobacterium pyogenes in the case of strain MN-H.…”
Section: Resultssupporting
confidence: 89%
“…Haemophilus parasuis , a Gram-negative bacterium of the Pasteurella group of organisms, is a respiratory pathogens of pigs ( Fu et al, 2013 ; Luan et al, 2013 ). It is mainly responsible for Glässer’s disease, which is characterized by polyserositis, arthritis, and meningitis ( Guo et al, 2011 ; Mullins et al, 2013 ; Moleres et al, 2015 ) and has caused large economic losses in the worldwide pig industry in recent years ( Vilalta et al, 2012 ; Zehr et al, 2012 ).…”
Section: Introductionmentioning
confidence: 99%
“…Vaccination with other members of the Pasteurellaceae family, as well as attenuated H . parasuis strains, can offer some cross-protection against virulent strains [ 6 , 7 , 13 ]. Subunit vaccines composed of bacterial ghosts, DNA, transferrin and other Haemophilus proteins have been evaluated, with the efficacy of the vaccines varying [ 14 18 ].…”
Section: Introductionmentioning
confidence: 99%