The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism

Sen, Paromita; Sherwin, Eoin; Sandhu, Kawaljit Singh; Bastiaanssen, Thomaz F.S.; Moloney, Gerard; Golubeva, Anna V.; Fitzgerald, Patrick; Silva, Ana Paula Ventura Da; Chruścicka-Smaga, Barbara; Olavarría-Ramírez, Loreto; Druelle, Clémentine; Campos, David; Jayaprakash, Pooja; Rea, Kieran; Jeffery, Ian B.; Savignac, Hélène M.; Chetal, Sasha; Mulder, Imke; Schellekens, Harriët; Dinan, Timothy G.; Cryan, John F.

doi:10.1016/j.bbi.2022.08.007

Cited by 31 publications

(19 citation statements)

References 93 publications

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“…The strain regulates the feces microbial metabolite profile with increased expression of oxytocin, arginine, vasopressin, and its receptors. These metabolic changes were correlated with attenuation of social and behavioral deficits of the ASD mice in the study …”

Section: Routes Of Gut–brain Communicationmentioning

confidence: 73%

“…These metabolic changes were correlated with attenuation of social and behavioral deficits of the ASD mice in the study. 101 GIM dysbiosis has also been studied in a pediatric cohort of neurodevelopmental disorders (NDD) to show that the intestinal microbial diversity is significantly lower in NDD children compared to healthy children. 102 Neuroinflammation is one of the key characteristics of NDD.…”

Section: Microbiota Derivedmentioning

confidence: 99%

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Short-Chain Fatty Acids in the Microbiota–Gut–Brain Axis: Role in Neurodegenerative Disorders and Viral Infections

Majumdar

Venkatesh

Basu

2023

ACS Chem. Neurosci.

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The gut–brain axis (GBA) is the umbrella term to include all bidirectional communication between the brain and gastrointestinal (GI) tract in the mammalian body. Evidence from over two centuries describes a significant role of GI microbiome in health and disease states of the host organism. Short-chain fatty acids (SCFAs), mainly acetate, butyrate, and propionate that are the physiological forms of acetic acid, butyric acid, and propionic acid respectively, are GI bacteria derived metabolites. SCFAs have been reported to influence cellular function in multiple neurodegenerative diseases (NDDs). In addition, the inflammation modulating properties of SCFAs make them suitable therapeutic candidates in neuroinflammatory conditions. This review provides a historical background of the GBA and current knowledge of the GI microbiome and role of individual SCFAs in central nervous system (CNS) disorders. Recently, a few reports have also identified the effects of GI metabolites in the case of viral infections. Among these viruses, the flaviviridae family is associated with neuroinflammation and deterioration of CNS functions. In this context, we additionally introduce SCFA based mechanisms in different viral pathogenesis to understand the former’s potential as agents against flaviviral disease.

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Section: Routes Of Gut–brain Communicationmentioning

confidence: 73%

Section: Microbiota Derivedmentioning

confidence: 99%

Short-Chain Fatty Acids in the Microbiota–Gut–Brain Axis: Role in Neurodegenerative Disorders and Viral Infections

Majumdar

Venkatesh

Basu

2023

ACS Chem. Neurosci.

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“…A cohort study (n = 108) reported that a lower proportion of B. hansenii could increase the risk of AD (Haran et al, 2019). A new study demonstrated that oral Blautia stercoris MRx0006 can attenuate some of the behavioral deficits in an autismrelevant genetic mouse model (Sen et al, 2022). Additionally, a prospective study showed that the abundance of Blautia in PD patients was decreased, and the scores of neuropathological indicators were improved after fecal microbial transplantation with an increased abundance of Blautia (Kuai et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Profiling Blautia at high taxonomic resolution reveals correlations with cognitive dysfunction in Chinese children with Down syndrome

Hou

Wu²,

Ren³

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionDown syndrome (DS), the presence of a supernumerary chromosome 21, is associated with cognitive dysfunction caused by early neurodegenerative processes. Alterations in the gut microbiota were observed in Chinese children with DS, and the genus Blautia was associated with cognitive function in these children. Therefore, it is crucial to understand the detailed composition of this group at the species level and to explore the effect of specific species on cognitive function.MethodsIn this study, Blautia-specific amplicon sequencing was conducted to identify the specific Blautia species in 15 children with DS and 15 matched healthy children.ResultsThe taxonomic analyses suggested that the Blautia taxa were clustered by disease status. The diversity of Blautia at the species level differed between DS patients and healthy controls, with the abundances of Blautia massiliensis and Blautia argi decreasing in DS children, while Blautia faecis was increased. Acetic acid, one of the metabolites of Blautia, was significantly reduced in the DS group. Of particular interest, Kyoto Encyclopaedia of Genes and Genomes analysis revealed decreased modules related to starch and sucrose metabolism and glycolysis. In addition, B. argi was positively related to DS cognitive scores, and B. faecis was negatively related to cognitive function, implying its role on the DS cognitive impairments. DiscussionOur study has important implications for understanding the important effects of specific species of Blautia on cognitive function and thus possibly provides a new strategy for future studies of cognitive improvement in individuals with DS.

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“…At the level of the brain, Oxt administration enhances functional connectivity between the ventral PFC and striatum, 126 which suggests that the mesocorticolimbic system is potentially involved in this Oxt‐mediated effects on ASD. Microbiome‐targeting strategies such as administration of Blautia stercoris MRx0006 ameliorate autistic‐like behavior and increase OXT protein levels and Oxt expression in the hypothalamus, in genetic mouse models of ASD (Shank3B −/− ) 19 (see Table 1). Administration of L. reuteri MM4‐1A to Shank3B −/− mice restored social interaction and VTA plasticity, effects which were prevented in mice lacking the Oxtr in dopaminergic neurons 17 .…”

Section: Physiological Functions Of Oxytocin and Effects Of The Micro...mentioning

confidence: 99%

“…Noteworthy, the probiotic Limosilactobacillus reuteri (formerly known as Lactobacillus reuteri ) has been shown to not only increase circulating Oxt levels 12 but also Oxt expression in the brain 13 in rodents, effects which have been linked with metabolism, 14,15 wound healing, 12 sociability and behavior 14,16,17 . Whilst the effects of Limosilactobacillus reuteri have been reviewed elsewhere, 16 recently other bacterial strains such as Blautia stercoris MRx006 and bacteria‐derived metabolites, such as 4‐ethylphenylsulfate (4EPS), have also demonstrated ability to modify social and sensorimotor behavior and hypothalamic Oxt expression in rodents 18,19 . Furthermore, a recent randomized controlled trial performed by Narmaki et al 20 showed that probiotic administration (multistrain probiotic ≈10 10 CFU per day, 12 weeks) increased Oxt serum levels in obese women with food addiction 20 .…”

Section: Introductionmentioning

confidence: 99%

Microbes, oxytocin and stress: Converging players regulating eating behavior

Cuesta-Marti

Uhlig

Muguerza

et al. 2023

J Neuroendocrinology

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Oxytocin is a peptide‐hormone extensively studied for its multifaceted biological functions and has recently gained attention for its role in eating behavior, through its action as an anorexigenic neuropeptide. Moreover, the gut microbiota is involved in oxytocinergic signaling through the brain‐gut axis, specifically in the regulation of social behavior. The gut microbiota is also implicated in appetite regulation and is postulated to play a role in central regulation of hedonic eating. In this review, we provide an overview on oxytocin and its individual links with the microbiome, the homeostatic and non‐homeostatic regulation of eating behavior as well as social behavior and stress.

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The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism

Cited by 31 publications

References 93 publications

Short-Chain Fatty Acids in the Microbiota–Gut–Brain Axis: Role in Neurodegenerative Disorders and Viral Infections

Short-Chain Fatty Acids in the Microbiota–Gut–Brain Axis: Role in Neurodegenerative Disorders and Viral Infections

Profiling Blautia at high taxonomic resolution reveals correlations with cognitive dysfunction in Chinese children with Down syndrome

Microbes, oxytocin and stress: Converging players regulating eating behavior

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