The liver fluke<i>Opisthorchis felineus</i>: biology, epidemiology and carcinogenic potential

Pakharukova, Maria Y.; Mordvinov, Viatcheslav A.

doi:10.1093/trstmh/trv085

Cited by 107 publications

(83 citation statements)

References 30 publications

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“…felineus (16) and a high prevalence of O. felineus infection in autopsy studies of patients with primary liver malignancies (fluke infection seen in 42 of 44 liver malignancy patients in one study) (32) . Additionally there are some animal data suggesting cholangiocarcinoma as a sequalae of O. felineus infection (33) .…”

Section: Cholangiocarcinomamentioning

confidence: 98%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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Section: Cholangiocarcinomamentioning

confidence: 98%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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“…Although malaria per se is not considered carcinogenic to humans by the IARC, the geographical association between the occurrence of malaria and that of Burkitt lymphoma provides a clue that malaria plays as a co-carcinogenic factor, together with EBV infection, for the development of Burkitt lymphoma (Molyneux et al, 2012). Other species of the genera Opisthorchis and Schistosoma are thought likely to be carcinogenic (Sripa et al, 2007, Pakharukova and Mordvinov, 2016). Intriguingly, Trypanosoma cruzi , the etiological agents of Chagas disease, displays apparently paradoxical roles in malignancy in exerting carcinogenic and anticancer properties (Krementsov, 2009, Sacerdote de et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity.

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“…not present in Opisthorchis . Juvenile Opisthorchis flukes ascend from the duodenum directly into the lumen of biliary tree [23,28].…”

Section: Discussionmentioning

confidence: 99%

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Gouveia

Pakharukova

Sripa

et al. 2019

Preprint

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50 Chronic infections with the flatworm parasites Opisthorchis viverrini, Clonorchis sinensis and 51 Schistosoma haematobium are classified as group 1 biological carcinogens, i.e. definitive causes 52 of cancer. In addition, we reported findings that support the inclusion of Opisthorchis felineus in 53 this list of biological carcinogens. By contrast, infections with close phylogenetic relatives 54 including Fasciola hepatica have not been associated with carcinogenesis. Earlier reports revealed 55 of oxysterol metabolites of Opisthorchis liver fluke origin conjugated with DNA bases, suggesting 56 that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of 57 the infection with these food-borne pathogens. Here we employed liquid chromatography-mass 58 spectrometry (LC-MS/MS) to investigate, compare and contrast spectrograms of soluble extracts 59 from F. hepatica adult worms from bile ducts of cattle with those from O. viverrini and O. felineus 60 from experimentally-infected hamsters. F. hepatica displayed a complex spectrophotometric 61 profile. F. hepatica and Opisthorchis spp. shared several common compounds including oxysterol-62 like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of these Opisthorchis 63 species included far fewer compounds than F. hepatica. These findings support the postulate that 64 oxysterol-like metabolites of parasite origin can initiate carcinogenesis and they point to a 65 molecular basis for the inconsistencies among major groups of liver flukes concerning infection-66 induced malignancy. 67 (202 words) 68 69 70 71 72 73 4 74 Author Summary 75 Several species of trematodes are parasites of the human hepatobiliary tract. Infection with 76 two of these flukes, Clonorchis sinsensis and Opisthorchis viverrini, fresh water fish-borne 77 parasites that occur in East Asia is classified as group 1 carcinogens by the International Agency 78 for Research on Cancer (IARC), i.e. definitive causes of cancer in humans. By contrast, infection 79 with a different liver fluke, Fasciola hepatica, does not lead to malignant transformation of the 80 biliary tract. Given the close phylogeny of all three parasites, this difference in carcinogenicity is 81 intriguing and, if explained, likely of value in novel therapeutic approaches. The importance of the 82 current findings is informative because they present a mass spectrometric analysis and catalog of 83 the similarities and differences between fluke of the genus Opisthorchis and F. hepatica, 84 potentially identifying carcinogenic metabolites of liver fluke origin. These metabolites can be 85 expected to provide deeper understanding of helminth infection induced malignancy. 86 (149 words) 87 88 89 90 91 92 Keywords 93 Fasciola hepatica, Opisthorchis viverrini; Opisthorchis felineus; oxysterols; DNA adducts 94 95 5 96 97 More than 20% of cancer in the developing world are caused by infections [1]. The World 98 Health Organization's International Agency for Research on Cancer (IARC) recognizes ...

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The liver flukeOpisthorchis felineus: biology, epidemiology and carcinogenic potential

Cited by 107 publications

References 30 publications

Human liver flukes

Human liver flukes

Parasite Infection, Carcinogenesis and Human Malignancy

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

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