The Liver Flukes: Clonorchis sinensis, Opisthorchis spp, and Metorchis spp.

Murrell, K. D.; Pozio, Edoardo

doi:10.14321/waterpathogens.44

Cited by 10 publications

(10 citation statements)

References 53 publications

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“…China and Japan), where Parafossarulus striatulus, Bulimus striatulus [66][67][68] and Bythinia sp. [69] can act as the first intermediate host. Adult trematodes commonly inhabit the bile duct and gallbladder of mammals, including humans, causing hepatitis and, in severe cases, even death [70,71].…”

Section: Discussionmentioning

confidence: 99%

Trematode diversity reflecting the community structure of Danish freshwater systems: molecular clues

et al. 2021

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Background Digenean trematodes are parasitic platyhelminths that use several hosts in their life cycles and are thereby embedded in various ecosystems affected by local environmental conditions. Their presence in a habitat will reflect the presence of different host species and, as such, they can serve as ecological indicators. Only limited information on the occurrence of trematodes and their link to other trophic levels in the Danish freshwater ecosystems is currently available.Therefore, the main aim of the present study was to increase our knowledge in this field. Methods Snails were sampled from 21 freshwater lakes in Denmark, following which shedding procedures were performed, cercariae were recoved and the released parasites were identified using molecular tools (PCR and sequencing). Results A total of 5657 snail hosts belonging to ten species were identified, revealing a highly diverse parasite fauna comprising 22 trematode species. The overall trematode prevalence was 12.6%, but large variations occurred between host species. The snail host Lymnaea stagnalis showed the highest prevalence and also exhibited the highest diversity, accounting for 47.6% of the species richness. Conclusions This survey contributes updated information on parasite–host relations and compatibility and may assist in describing the ecological structure of the investigated Danish freshwater ecosystems.

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Section: Discussionmentioning

confidence: 99%

Trematode diversity reflecting the community structure of Danish freshwater systems: molecular clues

et al. 2021

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“…viverrini : the family Bithyniidae and C . sinensis : the family Thiaridae and Bithyniidae) [79] with 3–4 copies of EC-SODs have a relatively broad spectrum of intermediate snail hosts than blood flukes ( S . japonicum : Oncomelania hupensis , S .…”

Section: Discussionmentioning

confidence: 99%

The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome

Xu¹,

Xu²,

Sun³

et al. 2019

PLoS Negl Trop Dis

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Angiostrongylus cantonensis (rat lungworm) is the etiological agent of angiostrongyliasis, mainly causing eosinophilic meningitis or meningoencephalitis in human. Although the biology of A. cantonensis is relatively well known, little is understood about the mechanisms of the parasite’s development and survival in definitive hosts, or its adaptation to a broad range of snail intermediate hosts. Here, we generate a high-quality assembly of a well-defined laboratory strain of A. cantonensis from Guangzhou, China, by using Illumina and PacBio sequencing technologies. We undertake comparative analyses with representative helminth genomes and explore transcriptomic data throughout key developmental life-cycles of the parasite. We find that part of retrotransposons and gene families undergo multiple waves of expansions. These include extracellular superoxide dismutase (EC-SOD) and astacin-like proteases which are considered to be associated with invasion and survival of the parasite. Furthermore, these paralogs from different sub-clades based on phylogeny, have different expression patterns in the molluscan and rodent stages, suggesting divergent functions under the different parasitic environment. We also find five candidate convergent signatures in the EC-SOD proteins from flukes and one sub-clade of A. cantonensis. Additionally, genes encoding proteolytic enzymes, involved in host hemoglobin digestion, exhibit expansion in A. cantonensis as well as two other blood-feeding nematodes. Overall, we find several potential adaptive evolutionary signatures in A. cantonensis, and also in some other helminths with similar traits. The genome and transcriptomes provide a useful resource for detailed studies of A. cantonensis-host adaptation and an in-depth understanding of the global-spread of angiostrongyliasis.

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“…Вторым промежуточным (дополнительным) хозяином служат рыбы семейства карповых, из которых наибольшее значение играют язь, плотва, елец, линь, гольян, пескарь и др. Человек заражается при употреблении в пищу рыбы, содержащей жизнеспособные метацеркарии возбудителя [1,2,22]. Меторхоз, вызванный различными видами возбудителя, широко распространен и регистрируется в Европе (Белоруссия, Великобритания, Германия, Испания, Молдавия, Украина, Франция), России, Азии (Казахстан, Китай (включая Тайвань), Корея, Япония, Вьетнам), Северной Америке (США, Канада) [1,2,22,23].…”

Section: клонорхозunclassified

“…Молекулярно-генетическому анализу может быть подвергнут интраоперационный или аутопсийный материал (содержимое желчных протоков, желчного пузыря или печени) [2,5,23,24,25]. Лечение и профилактика проводятся как при описторхозе [5,22].…”

Section: клонорхозunclassified

Trematodoses of the liver, bile ducts and pancreatic ducts (invasions caused by hepatic flukes)

Чуелов

Россина

2020

Det. infekc.

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The paper summarizes the information currently available in the literature on the etiology, life cycles, epidemiology, pathogenesis, pathomorphology, clinical manifestations, diagnosis, etiotropic therapy, and prevention of human liver, bile ducts and pancreatic ducts trematodiases: fascioliasis, opisthorchiasis, clonorchiais, metorchiasis, pseudamphistomiasis, amphimeriasis, dicrocoeliasis, eurytremiasis.

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The Liver Flukes: Clonorchis sinensis, Opisthorchis spp, and Metorchis spp.

Cited by 10 publications

References 53 publications

Trematode diversity reflecting the community structure of Danish freshwater systems: molecular clues

Trematode diversity reflecting the community structure of Danish freshwater systems: molecular clues

The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome

Trematodoses of the liver, bile ducts and pancreatic ducts (invasions caused by hepatic flukes)

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