The liver in Hodgkin's disease—II. Histopathologic findings

Skovsgaard, Torben; Brinckmeyer, L.M.; Vesterager, L; Thiede, T; Nissen, Nis I.

doi:10.1016/0277-5379(82)90110-9

Cited by 19 publications

(4 citation statements)

References 11 publications

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“…Additionally, non‐necrotizing epitheloid granulomas have been documented in up to 25% 33 of cases. In our series, all cases uniformly revealed portal tract infiltration with admixed Hodgkin cells (Figure 2D) that ensured discrimination from non‐specific reactive changes occurring in approximately 50% of patients suffering from this disease 30,34 . Reed–Sternberg cells were detected in only two cases, emphasizing their rarity in hepatic infiltration; lobular and/or portal granulomas were recorded in seven cases.…”

Section: Discussionsupporting

confidence: 53%

Patterns of liver infiltration in lymphoproliferative disease

et al. 2008

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Section: Discussionsupporting

confidence: 53%

Patterns of liver infiltration in lymphoproliferative disease

et al. 2008

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“…Organ size is a poor predictor of tumor involvement, unless enlargement is massive 36. In approximately 60% of all patients with untreated HD, benign, mostly lymphocytic hepatic infiltrates are associated with enlargement of the liver,37 and 30% of all splenic enlargements are related to nonmalignant causes 38. Ahmann et al36 reported a sensitivity of 38% and a specificity of 61% for the detection of splenic lymphoma on the basis of organ enlargement.…”

Section: Discussionmentioning

confidence: 99%

2-(fluorine-18)fluoro-2-deoxy-D-glucose positron emission tomography in the detection and staging of malignant lymphoma

Buchmann

Reinhardt

Elsner

et al. 2001

Cancer

213

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BACKGROUND The authors undertook a prospective evaluation of the clinical value of 2‐fluoro [18‐]‐2‐deoxyglucose positron emission tomography (FDG‐PET) in the detection and staging of malignant lymphoma compared with computed tomography (CT) and bone marrow biopsy (BMB). METHODS Fifty‐two consecutive patients with untreated malignant lymphoma were evaluated prospectively in a bicenter study. FDG‐PET, CT, and BMB were performed for investigating lymph node/extranodal manifestations and bone marrow infiltration. Thirty‐three percnt of the discrepant results were verified by biopsy, magnetic resonance imaging, or clinical follow‐up (range, 4–24 month). RESULTS Altogether, 1297 anatomic regions (lymph nodes, organs, and bone marrow) were evaluated. FDG‐PET and CT scans were compared by receiver operating characteristic (ROC) curve analysis. The area under the ROC curve were as follows: lymph nodes, 0.996 (PET) and 0.916 (CT); extranodal, 0.999 (PET) and 0.916 (CT); supradiaphragmatic, 0.996 (PET) and 0.905 (CT); and infradiaphragmatic, 0.999 (PET) and 0.952 (CT). In these analyses, FDG‐PET was significantly superior to CT (P < 0.05), except in infradiaphragmatic regions, in which the two methods produced equivalent results. In detecting bone marrow infiltration, FDG‐PET was superior to CT and was equivalent to BMB. In 4 of 52 patients (8%), FDG‐PET led to an upstaging and a change of therapy. CONCLUSIONS Noninvasive FDG‐PET is very accurate in the staging of malignant lymphoma. Compared with standard staging modalities (CT and BMB), PET was significantly superior and led to changes in the therapy regimen for 8% of patients. Cancer 2001;91:889–99. © 2001 American Cancer Society.

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“… 23 Except for the massive enlargement of the organ, the organ size is a poor predictor of tumor involvement. In approximately 60% of all untreated lymphoma cases, benign diseases and mostly lymphocytic hepatic infiltrates have been found with enlarged livers, 24 and 30% of all enlarged spleens have been found with nonmalignant causes. 25 Ahmann et al 26 reported a specificity of 61% and a sensitivity of 38% for the detection of spleen lymphomas on the basis of organ enlargement.…”

Section: Discussionmentioning

confidence: 99%

PET-CT for Evaluation of Spleen and Liver 18F-FDG Diffuse Uptake Without Lymph Node Enlargement in Lymphoma

et al. 2016

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The aim of the study was to compare differences between lymphoma and inflammation as indicated by high diffuse uptake of 18F-fluorodeoxyglucose (18F-FDG) in the spleen, liver, and bone marrow without increased 18F-FDG uptake in the lymph nodes and without enlarged peripheral lymph nodes.Eighteen lymphoma patients and 14 inflammation patients were examined with 18F-FDG positron emission tomography–computer tomography (PET-CT). All patients displayed high diffuse uptake of 18F-FDG in the spleen, liver, and bone marrow without increased 18F-FDG uptake in the lymph nodes and without enlarged peripheral lymph nodes. Our analyses compared the maximum standardized uptake values (SUVmax) of 18F-FDG uptake ratios between the spleen/liver, the spleen/bone marrow, and the liver/bone marrow and further compared spleen sizes between lymphoma and inflammation patients.Using Student t test, no significant differences were found in the SUVmax ratios of spleen/liver and liver/bone marrow between the lymphoma and inflammation patients (t = 0.853, P = 0.401 > 0.05; t = 1.622, P = 0.115 > 0.05). However, the SUVmax ratio of the spleen/bone marrow of the lymphoma patients was significantly different from that of the inflammation patients (t = 2.426, P = 0.021 < 0.05). The spleen size between the lymphoma and inflammation patients was also significantly different (t = 2.911, P = 0.007 < 0.05).As indicated by 18F-FDG PET-CT, our study demonstrated that lymphoma and inflammation patients displayed a few differences despite both having high diffuse uptake of 18F-FDG in the spleen, liver, and bone marrow without enlarged peripheral lymph nodes and without increased 18F-FDG uptake in lymph nodes.

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The liver in Hodgkin's disease—II. Histopathologic findings

Cited by 19 publications

References 11 publications

Patterns of liver infiltration in lymphoproliferative disease

Patterns of liver infiltration in lymphoproliferative disease

2-(fluorine-18)fluoro-2-deoxy-D-glucose positron emission tomography in the detection and staging of malignant lymphoma

PET-CT for Evaluation of Spleen and Liver 18F-FDG Diffuse Uptake Without Lymph Node Enlargement in Lymphoma

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