The liver in infectious mononucleosis

Myocardial involvement in infectious hepatitis

“…There is a difference of opinion concerning the exact nature of the hepatic lesion in infectious mononucleosis and it may be indistinguishable from that seen in infectious hepatitis. The findings in the single case where liver tissue was available showed parenchymal cell damage and the presence of lipochrome-containing Kupffer cells which are in favour of a diagnosis of infectious hepatitis (Sullivan et al, 1957). Furthermore, infectious hepatitis is endemic in this country.…”

Transaminase and Liver-function Studies in Infectious Mononucleosis

“…The superiority of the transaminases over conventional liver-function tests in their sensitivity to liver injury and ability to reflect the patient's clinical state indicates that where transaminase determination is available other tests of liver function may be unnecessary. Like Sullivan et al (1957) we found that flocculation tests gave little information about. the extent or duration of liver involvement, whereas transaminase determination would seem the ideal laboratory test for following the course of illness, the effect of treatment, and the duration of liver damage.…”

“…Clinical (Mason and Adams, 1958), liver-function (Berk et al, 1948;Sullivan et al, 1957), and liver-biopsy (Nelson and Darragh, 1956;Sullivan et al, 1957) studies have indicated differences between the hepatitis of infectious mononucleosis and that of infective hepatitis. The transaminase pattern also differs from that found in infective hepatitis, since the levels are lower (they exceeded 500 units per ml.…”

“…However, the tests most often used to demonstrate impaired liver function, the thymol turbidity and the cephalin-cholesterol flocculation, are those which reflect alterations in serum proteins, alterations for which antibody production might be in part responsible; caution has therefore been exercised in regarding abnormal flocculation tests as evidence of liver damage. Nevertheless, Leibowitz (1953) in a review of clinical, chemical, biopsy, and post-mortem studies concluded that hepatitis was an integral feature of most, if not at all, cases of infectious mononucleosis, a conclusion confirmed by the almost invariable finding of inflammatory changes in the liver in the biopsy studies of Nelson and Darragh (1956) and Sullivan et al (1957). Wr6blewski and LaDue (1956) have shown that the levels of the serum glutamic-oxaloacetic and serum glutamic-pyruvic transaminases (S.G.O.T.…”

Hepatitis granulomatosa mit intrahepataler Cholestase

“…Im Gegensatz zu Kalk, der auch der Bangschen K rankheit einen zirrhogenen Einfluß zuschreibt, hält S h iff die nachfolgende Leberzirrhose für eine zufällige Koinzidenz beider K rankheits zustände. Es wird weiter angegeben, daß auch die Sarkoidose, welche in zwei Dritteln der Fälle die Leber betrifft [14,21], zur Vernarbung und bis zum Um bau des Lebergewebes führen kann.…”