The lncRNA HOXA11-AS Regulates Rab3D Expression by Sponging miR-125a-5p Promoting Metastasis of Osteosarcoma [Corrigendum]

Cao, Kejiang; Fang, Yueyang; Wang, Hao; Jiang, Zheng; Guo, Li; Hu, Yong

doi:10.2147/cmar.s353233

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“…Recent investigations showed that with the development of cervical cancer, the levels of miR-338-3p [5], miR-187 [6], and miR-433 [1] significantly decreased, but miR-221-3p expression upregulated [3]. Downregulation of miR-125a-5p had been revealed in colorectal cancer, gastric cancer, bladder cancer, and osteosarcoma [16,[41][42][43]. Our study found that miR-125a-5p levels also were downregulated in cervical cancer tissues, demonstrating that it could be connected with cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway

et al. 2020

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Background The carcinogenesis and progression of cervical cancer is a complex process in which numerous microRNAs are involved. The purpose of this study is to investigate the role of miR-125a-5p in progression of cervical cancer. Methods RT-qPCR was used to detect the expression of miR-125a-5p and GALNT7 in cervical cancer tissues and cell lines. Then, the miR-125a-5p mimic, miR-125a-5p inhibitor, GALNT7 siRNA, or/and pcDNA-GALNT7 were respectively transfected into HeLa and Caski cervical cancer cells, and Cell Counting kit-8 assay, Transwell assay and flow cytometry analysis were respectively used to observe cell proliferation, invasion and apoptosis. Subsequently, luciferase reporter gene assay was employed in confirming the target relationship between miR-125a-5p and GALNT7. MiR-125a-5p mimic or/and pcDNA-GALNT7 were transfected into the cervical cancer cells at the absence of epidermal growth factor (EGF) or not, and the pcDNA-GALNT7 was transfected into the cervical cancer cells at the absence of inhibitors of multiple kinases or not. Furthermore, the effect of miR-125a-5p on tumor growth was also studied using a xenograft model of nude mice. Results MiR-125a-5p was down-regulated in both cervical cancer tissues and cell lines and it inhibited cell proliferation and invasion of cervical cancer cells. MiR-125a-5p directly targeted and post-transcriptionally downregulated GALNT7 that was strongly upregulated in cervical cancer tissues and cell lines. Similar to the effect of miR-125a-5p mimic, silencing GALNT7 inhibited proliferation and invasion of cervical cancer cells. In addition, miR-125a-5p overexpression could counteract both GALNT7- and EGF-induced cell proliferation and invasion. GALNT7 promoted cell proliferation and invasion by activating the EGFR/PI3K/AKT kinase pathway, which could be abated by the inhibitors of the kinases. Moreover, the role of miR-125a-5p inhibited tumor formation in cervical cancer by suppressing the expression of GALNT7 in vivo. Conclusion In conclusion, miR-125a-5p suppressed cervical cancer progression by post-transcriptionally downregulating GALNT7 and inactivating the EGFR/PI3K/AKT pathway.

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Section: Discussionmentioning

confidence: 99%

miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway

et al. 2020

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show abstract

The lncRNA HOXA11-AS Regulates Rab3D Expression by Sponging miR-125a-5p Promoting Metastasis of Osteosarcoma [Corrigendum]

Abstract: The authors have advised due to an error at the time of figure assembly, Figure 3B on page 4512 is incorrect. The correct Figure 3 is shown below.

Cited by 1 publication

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miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway

miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway

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