The location of atrial receptors in the dog: a physiological and histological study

Coleridge, J. C. G.; Hemingway, A. P.; Holmes, Robert L.; Linden, R. J.

doi:10.1113/jphysiol.1957.sp005750

Cited by 139 publications

(108 citation statements)

References 32 publications

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“…Respiration was recorded with an optical manometer attached to a side arm on the tracheal cannula, or to a fish-tailed cannula in the lateral pleural space when the animal was breathing spontaneously. Details of the recording techniques have been described previously (Coleridge, Hemingway, Holmes & Linden, 1957).…”

Section: Action Potential 8tudie8mentioning

confidence: 99%

A search for pulmonary arterial chemoreceptors in the cat, with a comparison of the blood supply of the aortic bodies in the new‐born and adult animal

Coleridge¹,

Coleridge²,

Howe³

1967

The Journal of Physiology

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SUMMARY1. Electrophysiological and histological techniques have been employed to search for pulmonary arterial chemoreceptors in kittens and cats.2. In cats, impulses were recorded from vagal fibres arising from chemoreceptors in the aortico-pulmonary region. The receptors were identified by their response to hypoxia, and their location was investigated by comparing the effects of injecting drugs at various sites in the pulmonary and systemic circulations. In only one of a large number of experiments did a chemoreceptor appear to receive pulmonary rather than systemic arterial blood.3. No chemoreceptor impulses were evoked when a segment of the pulmonary artery was perfused as described by Duke, Green, Heffron & Stubbens (1963).4. The vasculature of the aortico-pulmonary bodies was displayed by micro-dissection following injection of coloured gelatin masses, and the bodies were examined histologically. In the new-born kitten, the pulmonary artery invariably furnished a branch to some aortic bodies but the vessel frequently anastomosed with systemic arteries. As post-natal development proceeded the vessel became occluded, and in most kittens more than a month old and in forty-one of forty-three cats the aortic bodies were supplied wholly by systemic arteries.5. It was concluded that a pulmonary arterial supply to aortic bodies in the adult animal is an uncommon variation owing to the abnormal persistence of a foetal condition.6. Results indicated that the nomenclature introduced by Howe (1956) is, with slight modification, a useful method of classifying the various groups of aortic bodies according to their position, blood supply and innervation. 2,3 Physiol. i9I

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Section: Action Potential 8tudie8mentioning

confidence: 99%

A search for pulmonary arterial chemoreceptors in the cat, with a comparison of the blood supply of the aortic bodies in the new‐born and adult animal

Coleridge¹,

Coleridge²,

Howe³

1967

The Journal of Physiology

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“…The brown-colored baroreceptive areas with positive ChE activity were small patches composed of fine fibrous nets, which probably correspond to the areas of fine plexiform nerve fibers as revealed by silver impregnation (8) or methylene blue staining (8,9,14,21,22). The enzyme activity demonstrated in the cardiac baroreceptor is non-specific ChE as was proven by the inhibition experiment.…”

Section: Discussionmentioning

confidence: 88%

“…On the basis of evidence obtained from physiological experiments (7,8,23) it has been generally accepted that cardiac baroreceptors exist in the atria of the mammalian heart. Morphological identification of presumable baroreceptors has been carried out by methylene blue staining (8,9,14,21,22) and by silver impregnation (8).…”

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Electron microscopic histochemistry of cholinesterase activity in the baroreceptor of the cat atrial endocardium.

Yokota

Idé

Mitatori

et al. 1983

Acta Histochem. Cytochem

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“…However, owing to technical difficulties, there is little direct information about the respiratory changes in effective right atrial pressure in the intact cat, and none about the changes in the left atrium; and although atrial impulse activity has been recorded in the dog (e.g. Henry & Pearce, 1956;Coleridge, Hemingway, Holmes & Linden, 1957) it has not been directly related to effective atrial pressure in the intact dog. Consequently, in the absence of more direct information, it is interesting that some parallels can be found between the changes in impulse frequency in atrial fibres (Whitteridge, 1948;Paintal, 1953) and the changes in effective atrial pressure during respiration described in this paper.…”

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The variations with respiration in effective right and left atrial pressures in the dog

Coleridge¹

1959

The Journal of Physiology

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Opdyke & Brecher (1950) have described the effect of respiration on effective right and left atrial pressures in anaesthetized dogs. Like all previous workers, they had first to open the chest in order to cannulate the left atrium; but Opdyke & Brecher then closed the chest and reduced the pneumothorax to restore natural respiration. However, with the development of a technique for cannulating the left atrium through the trachea (ARlison & Linden, 1953) and its application to the recording of effective atrial pressures in the dog (Coleridge & Linden, 1953), it became possible to make a direct study of the respiratory changes in effective pressure in the two atria without the necessity of opening the chest. This paper reports the respiratory changes in atrial pressures recorded by this method. The results differ in several respects from the findings of Opdyke & Brecher (1950). The results will also be discussed in relation to the respiratory variations in the discharge of receptors situated in the atria or great veins near the heart. METHODSExperiments were performed on ten dogs; two were anaesthetized with ether and chloralose (0-1 g/kg intravenously) and the remainder, following premedication with morphine sulphate (3 mg/kg subcutaneously), were given intravenously 0-25 ml./kg of a 1:1 mixture of Dial Compound (allobarbitone-urethane, Ciba) and sodium pentobarbitone (Nembutal, Abbott Laboratories Ltd.) solutions, followed 1 hr later by morphine sulphate (1.5 mg/kg subcutaneously).Pressure recording. The animals were placed supine with their chests intact. Pressures were recorded simultaneously from the right and left atria, and the aorta; intrathoracic pressure was recorded from the right medial pleural space. The right atrium was cannulated through the right external jugular vein, the left atrium and the right medial pleural space were approached through the trachea, and the aorta was cannulated through the left carotid artery, which was ligated. The technique of cannulation and the optical manometers used for recording pressures have been described previously (Coleridge & Linden, 1954).Complete manometer systems had undamped natural frequencies of 180 c/s for the right atrial system, 120 c/s for the left atrial system and 200-400 c/s for the arterial pressure recording system;

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The location of atrial receptors in the dog: a physiological and histological study

Cited by 139 publications

References 32 publications

A search for pulmonary arterial chemoreceptors in the cat, with a comparison of the blood supply of the aortic bodies in the new‐born and adult animal

A search for pulmonary arterial chemoreceptors in the cat, with a comparison of the blood supply of the aortic bodies in the new‐born and adult animal

Electron microscopic histochemistry of cholinesterase activity in the baroreceptor of the cat atrial endocardium.

The variations with respiration in effective right and left atrial pressures in the dog

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