“…For reasons discussed above, the superior position of the MSO is arguably a factor contributing to high incidences of MS pathology among humans (Souza et al, 2016). While numerous studies have investigated the frequency of MS pathology (Ikeda, 1996;Perloff et al, 2000;Sánchez Fernández et al, 2000;Slavin et al, 2005;Roberts, 2007) and the position of the MSO relative to specific nasal landmarks for surgical purposes (Myerson, 1932;Van Alyea, 1936;Prasanna and Mamatha, 2010;Souza et al, 2016), few studies have systematically investigated how variations in MS size and/or shape relate to MSO position (an exception being Souza et al, 2016, see below). While human MSs are often described as pyramidal in shape, with the medial wall acting as the base of the pyramid and its apex extending laterally toward the zygoma (Skillern, 1923;Amedee, 1993;Singh and Tabaee, 2016;Souza et al, 2016), the size and shape of the MS are extremely variable at both the population (Shea, 1977;Fernandes, 2004b;Holton et al, 2013;Butaric, 2015;Butaric and Maddux, 2016;Maddux and Butaric, 2017) and individual levels (Anagnostopoulou et al, 1991;Amedee, 1993;Miller and Amedee, 1997;Uchida et al, 1998;Kim et al, 2002;Fernandes, 2004a).…”