Accessibility to food stores offering nutritious and affordable options is critical to ensure urban residents lead healthy lives. However, the uneven distribution of diverse food options in U.S. cities has raised concerns about marginalized communities’ ability to obtain affordable and nutritious food. Transportation-related issues, like car-oriented urban form and sprawl, have created food deserts in cities, making it hard for marginalized communities to access affordable and healthy food. This lack of access has recently drawn the attention of urban planners to address food access-related equity issues. Spatial interaction models can help measure food access by examining how grocery store supply, demand, and proximity affect individuals’ access to necessary food. However, these measures do not always consider the pricing of food items, which can significantly affect food access for low-income individuals and families. We use a highly disaggregated measure tailored to measuring inequitable food accessibility by factoring grocery store pricing into various types of supply and demand. Then, using regional socio-demographic thresholds, we identify target population groups and perform a series of equity analyses using our food accessibility measure. Our results show that walking is more inequitable than driving to food stores and that African American and Hispanic minorities, the elderly, and carless households are more burdened than the reference groups (whites). Using our framework, we identify food deserts and provide spatial and empirical insights for policymakers and planners to address food insecurity and promote equitable access to healthy food.