The loci of carbonic anhydrase activitiy in the ciliary epithelium of the rabbit eye: Electrophysiological study with isolated ciliary epithelial bilayer.

Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs

“…We hypothesize that carbonic anhydrase inhibitors delivered by different routes affect membrane-bound versus cytosolic car-bonic anhydrase differently. Although isoenzyme IV of carbonic anhydrase located on basolateral membranes of nonpigmented ciliary epithelial cells undoubtedly plays a critical role in IOP control, 25 the function (and even the existence) of isoenzyme IV in the cytosol of nonpigmented ciliary epithelial cells is less clear. [26][27][28] In the multiple-dose trial of our study, a significant decrease in AHFR was observed in response to treatment.…”