2020
DOI: 10.1016/j.bbr.2020.112600
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The locus coeruleus noradrenergic system gates deficits in visual attention induced by chronic pain

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Cited by 8 publications
(3 citation statements)
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“…Painful emotional stimulation can also activate neurons in the LC. In addition, stress activates LC neurons and enhances NE synthesis and secretion, pain perception in the prefrontal lobe, and sympathetic activity [36]. Experimental studies have also found that peripheral nerve injury induces neuronal plasticity of inhibitory neurons releasing γ-aminobutyric acid (GABA) in the LC and spinal dorsal horn, resulting in induction of anxiety after pain [37].…”
Section: Discussionmentioning
confidence: 99%
“…Painful emotional stimulation can also activate neurons in the LC. In addition, stress activates LC neurons and enhances NE synthesis and secretion, pain perception in the prefrontal lobe, and sympathetic activity [36]. Experimental studies have also found that peripheral nerve injury induces neuronal plasticity of inhibitory neurons releasing γ-aminobutyric acid (GABA) in the LC and spinal dorsal horn, resulting in induction of anxiety after pain [37].…”
Section: Discussionmentioning
confidence: 99%
“…Numerous prior studies have argued, either directly or indirectly, that several neurotransmitter systems involved in pain processing may also be implicated in attentional activity regulation. 27,[46][47][48] This paper's objective is to review the evidence that indicates that different neuromodulators (GABA, ACH, DA, NA, and 5HT) play a direct or indirect role in pain and attention. However, there is currently no direct evidence linking the two.…”
Section: Neurotransmitters and Receptors In Pain And Attention Processesmentioning
confidence: 99%
“…Alertness during visual tasks is commonly assessed using pupillometry, which has been shown to be an objective and reliable method (Vogels et al 2018 ; Zele and Gamlin 2020 ). Pupillary dilatations are suggested to result from increased activity of locus coeruleus (Marshall 2000 , 2007 ; Czerniak et al 2021 ), which is related to level of alertness (Moazen et al 2020 ) and can be altered in presence of pain (Moazen et al 2020 ). In general, alertness measured via pupillary responses can be divided into the slow adapting pupil dilatations representing tonic alertness (attending to various objects simultaneously) and high frequency pupillary responses representing phasic alertness (attending to a specific object) (O’Bryan and Scolari 2021 ).…”
Section: Introductionmentioning
confidence: 99%