The Locus of the Peripheral Vasodilator Action of Ethyl Alcohol, Tetraethylammonium and Priscoline

The Effect of Benzazoline (2-Benzyl-4,5-Imidazoline Hydrochloride) (Priscoline) On Renal Function in Hypertensive Man

“…In both animals and man, its principal action appears to be sympatholytic and adrenolytic (1,2), but sympathomimetic (3) and histamine-like (1) effects have also been described. Its most consistent action seems to be a peripheral vasodilating one (4,5). More generally, it inhibits the effect of epinephrine or even reverses its effect when administered prior to it (6)(7)(8)(9).…”

Use of Vasodilator Drugs in the Treatment of Diabetic Arteriosclerosis Obliterans*

“…Priscoline 2 has been used orally (14, 15), intramuscularly, intravenously (16, 17) and intra‐arterially (18) for about eight years, so that its value is well established. It is a combination of the histamine nucleus and the epinephrine nucleus, and therefore has a direct vasodilatory effect and also produces a peripheral adrenergic and sympathetic block (19). The oral dosage varies from 25 to 50 mg. every three to four hours.…”