The logit model as a way of integral assessment of oxidative stress induced by mechanical eye injury

Abstract

The eyes are exposed to aggressive environmental influences. The blood-ophthalmic barrier is one of the resistance mechanisms serving to protect the body. Mechanical eye trauma violates the integrity of the hematoophthalmic barrier and induces oxidative stress on the background of general inflammatory process with cellular structures disturbances. The aim of our study was to investigate the peculiarities of free radical processes and antioxidant protection of the organism under induced oxidative stress by mechanical eye injury. The experiment was conducted on males of six months of age in an amount of 150. In blood, liver, brain, heart and skeletal muscle tissues we studied the state of enzyme indicators of oxidative stress in the dynamics in intact animals and in rats with violation of the blood-ophthalmic barrier by mechanical eye injury and different types of therapy. Based on the data obtained, we performed an integral assessment of oxidative homeostasis in injured animals using a logistic model. The resulting logistic regression equations allow modifying the redox processes in the body by applying biologically active compounds as additional therapy, but are of more fundamental than practical interest, as they illustrate the interrelationships of lipid peroxidation-antioxidant system enzymes in the tissues under study.

Effect of quetiapine on morphologic manifestations of traumatic inflammation during mechanical impact on the blood-ophthalmic barrier

“…Group 2 rats received standard therapy for eye injury, group 3 animals received standard therapy with the addition of intraperitoneal quercetin injections, and group 4 received quercetin injections only. The detailed methodology of the experiment is presented in our previously published work [19]. Animals were maintained throughout the experiment on standard vivarium chow with free access to water and food [20].…”