The long non-coding RNA T cell leukemia homeobox 1 neighbor enhances signal transducer and activator of transcription 5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis

Chen, Guanyang; Lian, Dongbo; Жао, Леи; Wang, Zheng; Wuyun, Qiqige; Zhang, Nengwei

doi:10.1080/21655979.2022.2068781

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Further, they concluded that TLX1NB may be an early biomarker for the recurrence of low-grade gliomas. Chen et al ( 46 ) found that the expression of TLX1NB was up-regulated in colon cancer tissue. They confirmed that TLX1NB can promote the invasion, migration, and metastasis of colon cancer cells by promoting the phosphorylation of STAT5A and it also played an important role in regulating cancer.…”

Section: Discussionmentioning

confidence: 99%

Novel cuproptosis-related lncRNAs can predict the prognosis of patients with multiple myeloma

Chen,

Tang,

Chen

et al. 2023

Transl Cancer Res

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Background Cuproptosis-related long-stranded non-coding RNAs (lncRNAs) have several implications for the prognosis of multiple myeloma (MM). This research aimed to construct a prognostic risk model for MM patients and explore the potential signaling pathways in the risk group. Methods Cuproptosis-related lncRNAs were obtained from the co-expression analysis of cuproptosis-related genes and lncRNAs. Subsequently, twelve cuproptosis-related lncRNAs were selected to construct a prognostic risk model of MM patients by the least absolute shrinkage and selection operator (LASSO) regression. Then, the clinical data of these patients were randomly divided into the training group and the testing group. Next, patients were divided into the low- and high-risk groups according to the median risk score. The Kaplan-Meier survival analysis was performed to clarify the prognostic differences between risk subtypes. Besides, the Cox analysis was conducted to identify whether the risk score can be used as an independent prognostic factor. In addition, the receiver operating characteristic (ROC) curve analysis and the concordance index (C-index) curve analysis were performed to elucidate the value of risk score as a prognostic indicator. Finally, the differential risk analysis and functional enrichment analysis were carried out to identify the potential signaling pathways in the low- and high-risk groups. Results The results demonstrated that the overall survival (OS) of patients in the high-risk group was shorter than that in the low-risk group. There were significant differences in the expression of genes in MM patients between the high- and low-risk groups. The Gene Ontology (GO) analysis results showed that the differentially expressed risk-related genes (DERGs) were mainly concentrated on the collagen-containing extracellular matrix. According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis results, the DERGs may be related to the neuroactive ligand-receptor interaction and mitogen-activated protein kinase (MAPK) signaling pathway, indicating that they may be involved in the progression of tumors. Conclusions The findings of this study suggest that cuproptosis-related lncRNAs may be effective biomarkers for predicting the prognosis of MM patients, which is anticipated to contribute to the improvement of clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Novel cuproptosis-related lncRNAs can predict the prognosis of patients with multiple myeloma

Chen,

Tang,

Chen

et al. 2023

Transl Cancer Res

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“…There was an evident reduction in pulmonary metastatic nodules in experimental mice injected with TLX1NB-silenced-SW620 cells. Levels of p-STAT5A were found to be suppressed in the metastatic nodules from mice injected with TLX1NB-silenced-SW620 cells [ 64 ].…”

Section: Regulation Of Oncogenic Stat5 By Lncrnasmentioning

confidence: 99%

Interplay between JAK/STAT pathway and non-coding RNAs in different cancers

Farooqi,

Shepetov,

Rakhmetova

et al. 2024

Non-coding RNA Research

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Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer

et al. 2023

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Background: The molecular mechanism underlying the progression of gastric cancer (GC) remains unclear, the overexpression level of SALL4 has been demonstrated in many cancers and participated in tumorigenesis, however, it is still ambiguous for the expression and function of SALL4 in GC, especially its upstream mechanistic modulators.Method: Analysis of discrepant gene expression in GC and normal gastric tissues from The Cancer Genome Atlas (TCGA) dataset. Cultured GC cell lines were treated with siEZH2 and siKDM6A and checked for their in uences on SALL4, the transduction molecules of KDM6A/EZH2-SALL4-β-catenin signaling were quanti ed in the GC cells.Results: Here, we showed that only SALL4 levels of SALL family members were upregulated in nonpaired and paired GC tissues than those in corresponding normal tissues and were associated with its histological types, pathological stages, TNM stages, and overall survival from the TCGA dataset. SALL4 level was elevated in GC cells compared to normal gastric epithelial cell line (GES-1) and was correlated to cancer cell progression and invasion through the Wnt/β-catenin pathway in GC, which levels would be separately upregulated or downregulated by KDM6A or EZH2. Conclusion:We rst proposed and demonstrated that SALL4 promoted GC cell progression via the Wnt/βcatenin pathway, which was mediated by the dual regulation of EZH2 and KDM6A on SALL4. This mechanistic pathway in gastric cancer represents a novel targetable pathway.

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The long non-coding RNA T cell leukemia homeobox 1 neighbor enhances signal transducer and activator of transcription 5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis

Cited by 4 publications

References 38 publications

Novel cuproptosis-related lncRNAs can predict the prognosis of patients with multiple myeloma

Novel cuproptosis-related lncRNAs can predict the prognosis of patients with multiple myeloma

Interplay between JAK/STAT pathway and non-coding RNAs in different cancers

Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer

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