The long noncoding RNA LTCONS5539 up-regulates the TRAF6-mediated immune responses in miiuy croaker (Miichthys miiuy)

Pan, Jiajia; Zheng, Wei; Sun, Yuena; Xu, Tianjun

doi:10.1016/j.fsi.2022.05.042

Cited by 5 publications

(3 citation statements)

References 60 publications

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“…However, its activity is coordinated through the interactions of its regulatory genes with other genes. For example, the lncRNA LTCONS5539 modulates innate immunity through the upregulation of TRAF6 in the mouse croaker (Pan et al 2022 ). In addition, Gao et al ( 2021 ) demonstrated that miR-2187 modulates the NF-κB and IRF3 pathways by targeting TRAF6 in fish.…”

Section: Discussionmentioning

confidence: 99%

“…GO analysis of cis-target genes of differentially expressed lncRNAs revealed enrichment of immune-related terms, such as regulation of phagosome maturation, negative regulation of interleukin-6 production, and negative regulation of tumor necrosis factor production, which have been reported to be regulated by the TRAF6 gene (Nagashima et al 2018 ). Pan et al ( 2022 ) investigated the role of lncRNA LTCON5539 and demonstrated that LTCON5539 increased the expression of antiviral genes and chemokines via the upregulation of TRAF6 gene expression. Additionally, IRL stimulates the NF-κB signaling pathway by binding to miR-27c-3p in fish (Zheng et al 2021a ).…”

Section: Discussionmentioning

confidence: 99%

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Effect of TRAF6 -knockout on gene expression and lncRNA expression in Epithelioma papulosum cyprini (EPC) cells

Abdellaoui,

Kim,

Kim

2023

Animal Cells and Systems

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TRAF6 is a key immune gene that plays a significant role in toll-like receptor signal transduction and activates downstream immune genes involved in antiviral immunity in fish. To explore the role of TRAF6 in Epithelioma papulosum cyprini (EPC) cells, we knocked out the TRAF6 gene using the Clustered Regularly Interspaced Short Palindromic Repeats-Cas9 (CRISPR-Cas9) technique and then analyzed the transcriptomes of the knockout cells. In this study, we identified that 232 transcripts were differentially expressed in naive cells. Using the pipeline, we identified 381 novel lncRNAs in EPC cells, 23 of which were differentially expressed. Gene Ontology enrichment analysis demonstrated that differentially expressed genes (DEG) are implicated in various immune processes, such as neutrophil chemotaxis and mitogen-activated protein kinase binding. In addition, the KEGG pathway analysis revealed enrichment in immune-related pathways (Interleukin-17 signaling pathway, cytokine-cytokine receptor interaction, and TNF signaling pathway). Furthermore, the target genes of the differentially expressed lncRNAs were implicated in the negative regulation of interleukin-6 and tumor necrosis factor production. These results indicate that lncRNAs and protein-coding genes participate in the regulation of immune and metabolic processes in fish.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of TRAF6 -knockout on gene expression and lncRNA expression in Epithelioma papulosum cyprini (EPC) cells

Abdellaoui,

Kim,

Kim

2023

Animal Cells and Systems

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“…In addition, C. butyricum regulates other metabolic pathways in the gut, as demonstrated by metabolomic analysis. For instance, C. butyricum can produce postbiotics, including bacteriocins and lipoteichoic acid, which regulate antioxidation and antibacterial functions ( Pan, 2006 ; Gao et al , 2011 ; Junghare et al. , 2012 ).…”

Section: Butyricum Interacts With Gut Microbes Toregulate Intestinal ...mentioning

confidence: 99%

Regulatory Effects of the Probiotic <i>Clostridium butyricum</i> on Gut Microbes, Intestinal Health, and Growth Performance of Chickens

et al. 2023

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Clostridium butyricum is an important probiotic for chickens and exerts various biological activities, including altering the composition of the intestinal microbiota, competing with other microorganisms for nutrients, improving the integrity of the intestinal mucosal system, changing the intestinal barrier, and improving overall host health. Intestinal microbes also play vital roles in maintaining the intestinal barrier, regulating intestinal health, and promoting chicken growth. During chicken production, chickens are vulnerable to various stressors that have detrimental effects on the intestinal barrier with significant economic consequences. C. butyricum is a known probiotic that promotes intestinal health and produces the short-chain fatty acid butyric acid, which is beneficial for the growth performance of chickens. This review elucidates the development and utilization of C. butyricum to improve intestinal barrier function and growth performance in chickens through its probiotic properties and interactions with intestinal microbes.

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Long noncoding RNA LTCONS6801 up-regulates TBK1 mediated antiviral innate immunity in miiuy croaker, Miichttys miiuy

Song¹,

Zheng²,

Xin³

et al. 2023

Fish & Shellfish Immunology

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The long noncoding RNA LTCONS5539 up-regulates the TRAF6-mediated immune responses in miiuy croaker (Miichthys miiuy)

Cited by 5 publications

References 60 publications

Effect of TRAF6 -knockout on gene expression and lncRNA expression in Epithelioma papulosum cyprini (EPC) cells

Effect of TRAF6 -knockout on gene expression and lncRNA expression in Epithelioma papulosum cyprini (EPC) cells

Regulatory Effects of the Probiotic <i>Clostridium butyricum</i> on Gut Microbes, Intestinal Health, and Growth Performance of Chickens

Long noncoding RNA LTCONS6801 up-regulates TBK1 mediated antiviral innate immunity in miiuy croaker, Miichttys miiuy

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