The long noncoding RNA‐ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR‐145 pathway

Yang, Pengxiang; Yang, Yue; An, Wei; Xu, Jianyu; Zhang, Gan; Jie, Jing; Zhang, Qingyuan

doi:10.1111/jgh.13606

Cited by 83 publications

(66 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Linc-ROR has a regulatory role in multiple cancer types. [91][92][93][94][95][96] Recent studies have shown that linc-ROR may function as a molecular sponge for miR-145 targets, such as OCT4, SOX2 and Nanog. 92 Hou et al 91 examined linc-ROR in breast tissue specimens and breast cancer cell lines.…”

Section: Hox Transcript Antisense Intergenic Rna (Hotair)mentioning

confidence: 99%

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

Hardin

Zhang

Helein

et al. 2017

Laboratory Investigation

View full text Add to dashboard Cite

The cancer stem-like cell (CSC) hypothesis postulates that a small population of cells in a cancer has self-renewal and clonal tumor initiation properties. These cells are responsible for tumor initiation, growth, recurrence and for resistance to chemotherapy and radiation therapy. CSCs can be characterized using markers such as SSEA-1, SSEA-4, CD44, CD24, ALDEFLUOR and others. CSCs form spheres when they are cultured in serum-free condition in low attachment plates and can generate tumors when injected into immune-deficient mice. During epithelial to mesenchymal transition (EMT), cells lose cellular adhesion and polarity and acquire an invasive phenotype. Recent studies have established a relationship between EMT and increased numbers of CSCs in some solid malignancies. Non-coding RNAs such as microRNAs and long non-coding RNAs (lncRNAs) have been shown to have important roles during EMT and some of these molecules also have regulatory roles in the proliferation of CSCs. Specific lncRNAs enhanced cell migration and invasion in breast carcinomas, which was associated with the generation of stem cell properties. The tumor microenvironment of CSCs also has an important role in tumor progression. Recent studies have shown that the interaction between tumor cells and the local microenvironment at the metastatic site leads to the development of premetastatic niche(s) and allows for the proliferation of the metastatic cells during colonization. The role of exosomes in the microenvironment during the EMT program is currently a major area of research. This review examines CSCs and the relationship between EMT and CSCs in solid tumors with emphasis on thyroid CSCs. The role of non-coding RNAs and of the microenvironment in EMT and in tumor progression are also examined. This review also highlights the growing number of studies that show the close association of EMT and CSCs and the role of exosomes and other elements of the tissue microenvironment in CSC metastasis. A better understanding of these mechanisms will lead to more effective targeting of primary and metastatic malignancies.

show abstract

Section: Hox Transcript Antisense Intergenic Rna (Hotair)mentioning

confidence: 99%

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

Hardin

Zhang

Helein

et al. 2017

Laboratory Investigation

View full text Add to dashboard Cite

show abstract

“…Zhang et al indicated that lincRNA‐ROR could act as a p53 repressor in response to DNA damage . Yang et al manifested that lincRNA‐ROR decreases sensitivity to radiotherapy via the negative regulation of p53 and may represent a potential target for the treatment of colorectal cancer . Studies also indicated that lincRNA‐ROR is under control of p53, which means the lincRNA‐ROR level is increased when p53 is induced.…”

Section: The Possible Mechanism Of Lncrna In Dcmmentioning

confidence: 99%

“…What is more, in nasopharyngeal carcinoma (NPC), lincRNA‐ROR played an important role in the progression of NPC, and the mechanism by which NPC resists chemotherapy might be that lincRNA‐ROR suppresses p53 signal pathway . Several studies have shown that the role played by p53 depends on the nature and intensity of different stimuli, and this process is tightly regulated by ROR …”

Section: The Possible Mechanism Of Lncrna In Dcmmentioning

confidence: 99%

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

Luo

Liu

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

Diabetic cardiomyopathy (DCM) can cause extensive necrosis of the heart muscle by metabolic disorders and microangiopathy, with subclinical cardiac dysfunction, and eventually progress to heart failure, arrhythmia, and cardiogenic shock; severe patients may even die suddenly. Long noncoding RNAs (lncRNAs) are a class of nonprotein-coding RNAs longer than 200 nucleotides. They have critical roles in various biological processes, including gene expression regulation, genomic imprinting, nuclear-cytoplasmic trafficking, RNA splicing, and translational control. Recent studies indicated that lncRNAs extensively participate in the development of diverse cardiac diseases, such as cardiac ischaemia, hypertrophy, and heart failure. Little is known about lncRNA in DCM. In this review, we summarize the current literature on lncRNAs in DCM studies, aiming to provide new methods for DCM's future prevention and treatment strategies.

show abstract

“…Moreover, lncRNAs-ROR was reported as p53 upstream gene. Upregulated lncRNAs-ROR could weak radiosensitivity of CRC cells via sponging miR-145 and impeding p53 translation, play an inhibited role in radiotherapy effect to CRC [66]. …”

Section: P53 Signalling Pathwaymentioning

confidence: 99%

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Sun¹,

Wang²,

Chen³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future.

show abstract

The long noncoding RNA‐ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR‐145 pathway

Abstract: LincRNA-ROR decreases sensitivity to radiotherapy via the negative regulation of p53/miR-145 and may represent a potential target for the treatment of CRC.

Cited by 83 publications

References 39 publications

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Contact Info

Product

Resources

About