Wireless integrated microsystems (WIMS), also referred to with many names such as IoT/IoE, sensor nodes/motes, or smart nodes, represent portable and stand-alone devices that contain sensors, actuators, signal processing electronics, communication electronics, packaging, and power sources. During the past few years they have become an instrumental part of extending the microelectronics revolution that started many decades ago with the advent of integrated circuits. This paper reviews the past achievements in sensors/actuators, low-power electronics, wireless interfaces, packaging, and provides a perspective on the future trends in both technology and applications for these sensing microsystems and high-performance micro-instruments.