The long shadow of our chemical past – High DDT concentrations in fish near a former agrochemicals factory in England

Jürgens, Monika D.; Crosse, John D.; Hamilton, Patrick B.; Johnson, Andrew C.; Jones, Kevin C.

doi:10.1016/j.chemosphere.2016.07.078

Cited by 35 publications

(28 citation statements)

References 47 publications

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“…Decades after being banned, wild fish from many locations in western Europe still contain elevated levels of DDT. For example, in a recent study from the UK, in which 81 roach ( Rutilus rutilus ) were collected from 13 southern English river sites between 2007 and 2012, very high ∑DDT concentrations, e.g., in average 88 μg kg –1 w/w, were found in fish from one site (Jürgens, Crosse, Hamilton, Johnson, & Jones, ). Roach from the other sites contain about 5 μg kg –1 .…”

Section: Introductionmentioning

confidence: 99%

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Metabolic effects of p,p′‐DDE on Atlantic salmon hepatocytes

Søfteland¹

2017

J of Applied Toxicology

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Decades after being banned in many countries, DDT and its metabolites are still considered major environmental hazards. The p,p'-DDE isomer, the DDT metabolite found in highest concentration in aquaculture feeds, is an endocrine disruptor with demonstrated ability to induce epigenetic effects. This study aimed at examining the impact of p,p'-DDE on Atlantic salmon. Primary hepatocytes were exposed to four concentrations of p,p'-DDE (0.1, 1, 10, 100 μm) for 48 hours, and endpoints included cytotoxicity, global DNA methylation, targeted transcription and metabolomics profiling (100 μm). p,p'-DDE was moderately cytotoxic at 100 μm. No impact was seen on global DNA methylation. Vtg1 and esr1 transcription, markers of endocrine disruption, was most strongly induced at 10 μm p,p'-DDE, while ar showed strongest response at 100 μm. Metabolomics profiling showed that p,p'-DDE at 100 μm most strongly affected carbohydrate metabolism, primary bile acid metabolism, leucine, isoleucine and valine metabolism, diacylglycerol and sphingolipid metabolism. Observed changes in lipid levels suggest that p,p'-DDE interferes with phospholipid membrane biosynthesis. Elevation of bile acid levels in p,p'-DDE-exposed hepatocytes indicates upregulation of synthesis of bile acids after cytochrome P450 activation. Pathway analysis showed that the superpathway of methionine degradation was the most significantly affected pathway by p,p'-DDE exposure, while endocrine system disorder topped the diseases and disorder ranking. In conclusion, this work predicts an endocrine response to p,p'-DDE exposure, and demonstrates how this legacy pesticide might interfere with mechanisms linked to DNA methylation in Atlantic salmon hepatocytes.

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Section: Introductionmentioning

confidence: 99%

“…rutilus) were collected from 13 southern English river sites between 2007 and 2012, very high DDT concentrations, e.g., in average 88 μg kg -1 w/w, were found in fish from one site (Jürgens, Crosse, Hamilton, Johnson, & Jones, 2016). Roach from the other sites contain about 5 μg kg -1 .…”

mentioning

confidence: 99%

Metabolic effects of p,p′‐DDE on Atlantic salmon hepatocytes

Søfteland¹

2017

J of Applied Toxicology

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“…Los pesticidas contienen compuestos químicos que resisten en distintos niveles la degradación y obligan a que cada uno de ellos deba ser tratado de modo particular para su eliminación o reducción (Domene, 2012). Se ha estudiado el tratamiento del DDD en agua a través de la nanofiltración (Pang et al, 2010;Jürgens et al, 2016), con residuos de bagazo de la industria azucarera (Gupta y Ali, 2001), materiales mesoporosos Fe-SBA-15 (Wang et al, 2012), fotodegradación (Ananpattarachai y Kajitvichyanukul 2015) y degradación a través de microorganismos (Carrillo-Pérez et al, 2004;Orozco-Borbón et al, 2008) y hongos (Thomas y Gohil, 2011).…”

Section: Introductionunclassified

Clinoptilolita natural mexicana tratada con plata para remover DDD en agua

et al. 2020

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Se estudió el efecto de la temperatura y de la variación de la concentración de plata en una clinoptilolita natural para remover DDD. Mediante las técnicas MEB-EDX y BET se analizó a la muestra natural y modificada. En las pruebas cinéticas se encontró que el equilibrio se presenta a los 180 minutos de contacto y que la plata incrementa la eficiencia de remoción. El proceso presenta una cinética por quimisorción, ya que se ajustó al modelo de pseudo segundo orden y los coeficientes de determinación variaron en un intervalo de 0.9933 a 0.9997. Por las isotermas de adsorción se obtuvo que la máxima concentración adsorbida es de 0.19 mg/g y los datos ajustaron perfectamente al modelo de Langmuir, en el cual se observa que la constante b, relacionada con la energía de adsorción, disminuye cuando hay aumento en la temperatura, lo que indica un decremento de la adsorción a altas temperaturas, teniendo que el orden de adsorción es 25 °C > 35 °C > 45 °C. Se concluye que el proceso es de naturaleza exotérmica, al tener que la adsorción es mayor cuando la temperatura es menor, corroborado por el cálculo de los parámetros termodinámicos (ΔH°, ΔG° y ΔS°).

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“…Sci. 2019, 9, 1722 2 of 11 p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), one of the main metabolites of DDT, can exist for decades in soils and aquatic sediments and have adverse effects on humans and the environment [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Addition of Carbonaceous Material to Aquatic Sediments for Sorption of Lindane and p,p’-Dichlorodiphenyldichloroethylene

Guo

Chen

Wang³

et al. 2019

Applied Sciences

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Isomers of hexachlorocyclohexanes (HCHs) and metabolites of dichlorodiphenyltrichloroethanes (DDTs) are still frequently detected worldwide in considerable amounts, even decades after their prohibition. Carbonaceous materials (CMs) have been shown to significantly reduce risks of propagation to humans by binding the hydrophobic organochlorine pesticides (OCPs) present in aquatic sediments. In the present study, black carbons extracted from natural sediments, and artificially produced black carbons, including black carbons by burning rice straw at 450 and 850 °C, and a commercial activated carbon were compared to investigate the factors affecting the sorption of γ-HCH (lindane) and p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) on CMs. The results indicated that when the proportion of CMs to total organic carbon (ƒCM/ƒOC) was greater than 0.35, CMs played a leading role in the sorption of lindane and p,p’-DDE by the sediments. The sorption contribution rate of CMs could reach up to 64.7%. When the ratio of ƒCM/ƒOC was less than 0.10, CMs played a minor role in the sorption. In addition, the nonlinearity of the sorption isotherms was strengthened with the increasing the proportion of CMs to total organic carbon. Our findings show that ƒCM/ƒOC value is a principal parameter for assessing the sorption capacity of sediments added by CMs for OCPs.

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The long shadow of our chemical past – High DDT concentrations in fish near a former agrochemicals factory in England

Cited by 35 publications

References 47 publications

Metabolic effects of p,p′‐DDE on Atlantic salmon hepatocytes

Metabolic effects of p,p′‐DDE on Atlantic salmon hepatocytes

Clinoptilolita natural mexicana tratada con plata para remover DDD en agua

Addition of Carbonaceous Material to Aquatic Sediments for Sorption of Lindane and p,p’-Dichlorodiphenyldichloroethylene

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