The Long-Term Course of Atopic Dermatitis

Temporal variation of Staphylococcus aureus clonal complexes in atopic dermatitis: a follow‐up study

“…Although it is most widely studied in children, the disease affects 2–10% of adults . In adulthood it may cause long‐lasting and severe symptoms, with a significant negative influence on health‐related quality of life . Skin barrier defects are a hallmark in AD and facilitate penetration and entry of microbes, giving patients with AD a predisposition to microbial skin infections .…”

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal

“…In assessing long‐term disease control, the study recorded objective and subjective outcomes at 4‐weekly intervals, proportion of topical and systemic rescue medication‐free days and incidence rate of flares (defined as worsening of AD requiring escalation or intensification of treatment). There are inherent challenges in studying a chronic, intermittent disease such as AD and, consequently, defining long‐term disease control is difficult, with no widely accepted or validated measure – a challenge that is currently being addressed by the HOME group.…”

How acute stress impacts the itch–scratch cycle in atopic dermatitis: a clinical lesson

“…In this context, it is of high importance to understand the clinically disruptive elements of these therapies and potential reasons for treatment nonresponders. Interestingly, there is still a lack of long‐term clinical research on the natural course of AD, which could address the above‐mentioned issues. This is most likely due to the methodological challenges of prospective studies, as AD is a lifelong disease .…”

“…Interestingly, there is still a lack of long‐term clinical research on the natural course of AD, which could address the above‐mentioned issues. This is most likely due to the methodological challenges of prospective studies, as AD is a lifelong disease . A longitudinal data analysis from the Pediatric Eczema Elective Registry of 5798 participants aged 2–26 years concluded that most patients in this cohort had active disease at all ages with only few or no periods of complete control without treatment .…”