The long term effect of age and maternally derived antibodies against foot and mouth disease on the serological response following vaccination in young dairy calves

Elnekave, Ehud; Dekker, A.; Eblé, P.L.; Hemert-Kluitenberg, Froukje van; Gelman, Boris; Storm, Nick; Klement, Eyal

doi:10.1016/j.vaccine.2016.07.052

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…The higher prevalence of FMD in cattle > 4 years than other age groups may be explained by the different grazing strategies used for cattle in various age groups. Weaners and adult cattle > 4 years were more likely to be exposed to FMD virus as they frequently contacted other herds and wildlife during grazing, while for calves, the low prevalence could be due to protective effects of maternally inherited antibodies that wane off as age increases (Elnekave et al 2016 ). The median age-specific mortalities for FMD were reported the highest in calves and to decrease with increasing cattle age.…”

Section: Discussionmentioning

confidence: 99%

A participatory epidemiological study of major cattle diseases amongst Maasai pastoralists living in wildlife-livestock interfaces in Maasai Mara, Kenya

Nthiwa

Alonso²,

Odongo

et al. 2019

Trop Anim Health Prod

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Livestock-wildlife interactions promote the transmission of a wide range of infectious diseases that constraint livestock production. We used a participatory appraisal approach to find out and rank infectious diseases of concern to pastoralists in a zone of intense wildlife-livestock interaction and another zone with limited interactions. Four villages were selected purposively in areas with intensive cattle-wildlife interactions (zone 1), and another two in areas with low to moderate cattle-wildlife interactions (zone 2). Data were collected in focus group discussions (FGDs) using participatory epidemiological methods (PE); each group had 8–13 participants. Results of impact matrix scoring from all sites indicated that malignant catarrhal fever (MCF), anthrax, foot and mouth disease (FMD), contagious bovine pleuropneumonia (CBPP), east coast fever (ECF) and African animal trypanosomiasis (ATT), in decreasing order, had the highest impact on livestock production. A Kruskal–Wallis test revealed a significant difference in FMD annual prevalence between cattle age groups ( p < 0.001) and was the highest in animals > 4 years (median score of 32.5, range, 10–50). FMD had the highest impact on milk production, but based on veterinary costs (treatment costs), it was ranked second to CBPP. The study provides information on disease priorities that occur in the target zones in Mara ecosystem and which the local pastoralists must consider when accessing key ecosystem services such as water and pasture. Electronic supplementary material The online version of this article (10.1007/s11250-018-01790-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A participatory epidemiological study of major cattle diseases amongst Maasai pastoralists living in wildlife-livestock interfaces in Maasai Mara, Kenya

Nthiwa

Alonso²,

Odongo

et al. 2019

Trop Anim Health Prod

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“…They concluded that vaccinations should be delayed until calves are at least 3 months old and that they should be given a high potency vaccine, preferably with a booster after one month. Elnekave et al (2016) [ 14 ] followed calves vaccinated three or four times (at 0, 4, 19 +/− 34 weeks) at ages up to 6 months for 70 weeks. Calves less than 3 months old responded relatively poorly, although a transient response was observed after a third and especially fourth vaccination; however, calves above 3 months old responded better.…”

Section: Discussionmentioning

confidence: 99%

“…However, this recommendation may be ignored, so that animals receive only a single dose of vaccine when first vaccinated. It is well established that maternally derived antibodies (MDA) to FMDV that are transferred in colostrum from immune dams to their offspring provide protection but interfere with the development of acquired immunity, although this interference varies with differences in the timing of vaccination of dams and especially calves, the potency of vaccines, the nature of the adjuvants within them, the amount and timing of colostral consumption and the different serological tests and test cut-off thresholds used to predict protection [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. This creates uncertainty about the effectiveness of FMD vaccination and what will be the most appropriate vaccination regime.…”

Section: Introductionmentioning

confidence: 99%

Maternally Derived Antibodies to Foot-and-Mouth Disease Virus Modulate the Antigenic Specificity of Humoral Responses in Vaccinated Cattle

Senawi,

Wilsden,

Browning

et al. 2023

Vaccines

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Vaccination is widely used to control foot-and-mouth disease (FMD), but maternal antibodies may interfere with the response to vaccination in calves. This study, conducted on a regularly vaccinated Malaysian dairy farm, aimed to optimise the vaccination regime by measuring the in vitro neutralising virus antibody responses of 51 calves before and after vaccination with a one or two dose vaccination regime starting at 2–7 months old. The presence of maternal antibodies was associated with poor post-vaccination antibody responses after a single dose of vaccine in calves less than 6 months old. However, a second dose of vaccine given three weeks later, improved the antibody responses in all ages of calves. This confirms the view that in regularly vaccinated farms, some combination of delay and revaccination is needed to achieve effective immunization of calves. Sera from cows and pre-vaccinated calves neutralised homologous serotype A vaccine virus more strongly than a heterologous serotype A field virus, but this pattern was reversed in some calves after vaccination. The strength of heterologous responses in calves 49 days after first vaccination correlated to the amount of transferred maternal antibody, suggesting that pre-existing antibodies could have modulated the specificity of these active antibody responses. If confirmed, such an effect by pre-existing antibodies could have wider implications for broadening the coverage of FMD vaccine responses.

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“…Various studies have reported the relationship between MDA interference and reduced efficacy of FMD vaccines 4 – 6 , and the optimal timing for vaccination in young animals 7 , 8 . However, few studies have suggested strategies for inducing a strong immune response by effectively overcoming MDA.…”

Section: Introductionmentioning

confidence: 99%

The C3d-fused foot-and-mouth disease vaccine platform overcomes maternally-derived antibody interference by inducing a potent adaptive immunity

et al. 2022

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Vaccination prevents and controls foot-and-mouth disease (FMD). However, the current FMD vaccine remains disadvantageous since it cannot overcome maternally-derived antibody (MDA) interference in weeks-old animals, which suppress active immunity via vaccination. To address this, we developed the immune-enhancing O PA2-C3d and A22-C3d FMD vaccine strains that can stimulate receptors on the surface of B cells by inserting C3d (a B cell epitope) into the VP1 region of O PA2 (FMDV type O) and A22 (FMDV type A). We purified inactivated viral antigens from these vaccine strains and evaluated their immunogenicity and host defense against FMDV infection in mice. We also verified its efficacy in inducing an adaptive immune response and overcome MDA interference in MDA-positive (MDA(+), FMD-seropositive) and -negative (MDA(−), FMD-seronegative) pigs. These results suggest a key strategy for establishing novel FMD vaccine platform to overcome MDA interference and induce a robust adaptive immune response.

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The long term effect of age and maternally derived antibodies against foot and mouth disease on the serological response following vaccination in young dairy calves

Cited by 10 publications

References 17 publications

A participatory epidemiological study of major cattle diseases amongst Maasai pastoralists living in wildlife-livestock interfaces in Maasai Mara, Kenya

A participatory epidemiological study of major cattle diseases amongst Maasai pastoralists living in wildlife-livestock interfaces in Maasai Mara, Kenya

Maternally Derived Antibodies to Foot-and-Mouth Disease Virus Modulate the Antigenic Specificity of Humoral Responses in Vaccinated Cattle

The C3d-fused foot-and-mouth disease vaccine platform overcomes maternally-derived antibody interference by inducing a potent adaptive immunity

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