The long‐term functional status in patients with Guillain‐Barré syndrome

Rudolph, Thomas; Larsen, Jan Petter; Farbu, Elisabeth

doi:10.1111/j.1468-1331.2008.02311.x

Cited by 31 publications

(41 citation statements)

References 18 publications

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“…As previously shown in Guillain Barré syndrome (GBS), our findings suggest, that fatigue is independent from muscle strength, sensory function and the Hughes score (Merkies et al, 1999;Rudolph et al, 2008). Axonal degeneration at long-term follow-up is typical in CIP and may also occur in GBS (Wolfe and Barohn, 1998;Dornonville and Jakobsen, 2005).…”

Section: Discussionsupporting

confidence: 79%

Chronic idiopathic polyneuropathy: Patients own perception of well-being in correlation to clinical condition

Rudolph¹,

Larsen²,

Farbu³

2011

J. Clin. Med. Res.

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Chronic idiopathic polyneuropathy (CIP) is a disease of the elderly where further follow-up is usually not indicated after diagnosis. The aim of the study was to evaluate the self-reported functioning and well-being in patients with CIP in correlation to clinical findings. We examined forty-eight patients with CIP. The Fatigue Severity Scale, Visual Analogue Scale for pain, Disability Rating Index, Berg Balance test and Medical Outcome Study 36-item short-form health status scale were correlated with clinical variables at long-term follow-up. Predominantly sensory symptoms and signs were found. Reduced balance and sensory function explained up to 31% of variance in self-reported physical impairment (p < 0.0001). Otherwise, self-reported functioning and well-being could not be explained by clinical symptoms. Sensory deficits and balance problems are typical in CIP, and reduced balance and sensory functioning partially explained impaired physical functioning and well-being. Further follow-up could be indicated to investigate the effect of specific training programs and whether other factors may contribute to impaired functioning and well-being as well.

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Section: Discussionsupporting

confidence: 79%

Chronic idiopathic polyneuropathy: Patients own perception of well-being in correlation to clinical condition

Rudolph¹,

Larsen²,

Farbu³

2011

J. Clin. Med. Res.

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“…Notably lower scores on physical dimensions have also been found in cross-sectional studies of HRQL several years after GBS, using the SIP [31] and the SF-36 [14,32]. Thus, it seems that persons with GBS recover quite well in terms of the psychosocial aspects of HRQL.…”

Section: Discussionmentioning

confidence: 82%

“…A good outcome after GBS has mostly been associated with the capability to regain walking ability, which is often assessed with the GBS disability score [10,11]. Apart from physical disabilities, studies have shown decreased health-related quality of life (HRQL) and higher fatigue 3-8 years after GBS onset [12][13][14]. Subjective experiences of HRQL and fatigue also seem to differ between persons with residual symptoms and those who have fully recovered [12].…”

Section: Introductionmentioning

confidence: 99%

Residual disability 10years after falling ill in Guillain–Barré syndrome: A prospective follow-up study

Forsberg

Holmqvist

2012

Journal of the Neurological Sciences

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“…The patients in this study reported severe fatigue as one of the most important symptoms leading to problems in school or work. Fatigue is also an important complaint after GBS in adults, which may in part be attributed to residual peripheral nerve damage (Merkies et al, ; Rudolph et al, ; Rekand et al, ; Drenthen et al, ). Garssen et al ( ) demonstrated a persistent decrease in fatigue after a bicycle exercise training program in adult GBS patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although most patients show a tendency to recover and proven effective treatments are available, GBS often has considerable long‐term effects (Bernsen et al, ) . Patients may have persistent neurological deficit, one‐third of patients report persistent pain and up to 60% report severe fatigue interfering with daily life (Merkies et al, ; Rudolph et al, ; Rekand et al, ) . This may have a negative impact on work, quality of life (QoL), and social functioning (Bernsen et al, ; Rudolph et al, ) .…”

Section: Introductionmentioning

confidence: 99%

Long‐term outcome of Guillain‐Barré syndrome in children

Roodbol

Wit

Aarsen

et al. 2014

J Peripheral Nervous Sys

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The objective of this study is to determine the long-term outcome and consequences of Guillain-Barré syndrome (GBS) in children. This is an observational cross-sectional cohort study of children diagnosed with GBS (0-18 years old) at the Sophia Children's Hospital in Rotterdam from 1987 to 2009. All patients were invited for a structured interview, questionnaires, and full neurologic exam to record their current clinical condition focused on complaints and symptoms, neurological deficits, disabilities, behavior, and quality of life. Thirty-seven patients participated, 23 were now adults, with a median age of 20 years (range 4-39 years) and a median follow-up time of 11 years (range 1-22 years). Residual complaints were reported by 24 (65%) patients, including paresthesias (38%), unsteadiness of gait in the dark (37%), painful hands or feet (24%), and severe fatigue (22%). Four patients had severe neurological deficits, including facial diplegia and limb weakness. Two patients had had a recurrence of GBS. In 10 patients (26%), GBS had a negative impact on their school career. Questionnaires identified a wide range of behavioral problems. Quality of life was below normal on the subscale vitality, and above normal on the subscales social functioning and positive emotions in the adult group. Most children show good recovery of neurological deficits after GBS, but many have persisting long-term residual complaints and symptoms that may lead to psychosocial problems interfering with participation in daily life.

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The long‐term functional status in patients with Guillain‐Barré syndrome

Abstract: Relatively independent from various variables at onset, patients with GBS seem to have a reduced quality of life and functioning, and the distress seems to have become persistent after the first few years with improvement following the acute disease.

Cited by 31 publications

References 18 publications

Chronic idiopathic polyneuropathy: Patients own perception of well-being in correlation to clinical condition

Chronic idiopathic polyneuropathy: Patients own perception of well-being in correlation to clinical condition

Residual disability 10years after falling ill in Guillain–Barré syndrome: A prospective follow-up study

Long‐term outcome of Guillain‐Barré syndrome in children

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