The long-term outcome of childhood nephrotic syndrome in Germany: a cross-sectional study

Aydin, Malik; Franke, Ingo; Kurylowicz, Lisa; Ganschow, Rainer; Lentze, Michael J.; Born, Mark; Hagemann, Rebekka

doi:10.1007/s10157-019-01696-8

Cited by 24 publications

(55 citation statements)

References 45 publications

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“…The relatively higher prevalence reported by Kyrieleis et al seems to have been affected by their pool of patients, which only included patients who were continuously relapsing as adults. Estimates from two German groups showed a very low prevalence of short stature . There were no patients with short stature in the more recent study, and in the older study, short stature was only present in one female patient who had a continuous steroid prescription due to vasculitis and arthritis.…”

Section: Growth and Heightmentioning

confidence: 70%

“…There were no patients with short stature in the more recent study, and in the older study, short stature was only present in one female patient who had a continuous steroid prescription due to vasculitis and arthritis. When the patients in these studies reached adulthood, the final height scores were −0.2 SD and −0.4 SD, respectively, compared to the general population average. Data from these two studies were compared to their genetically expected target height and did not show any difference.…”

Section: Growth and Heightmentioning

confidence: 70%

“…Thus, they suggested that NS in childhood did not increase the risk of overweight and obesity during the long‐term follow‐up period . We also reviewed two German studies . The prevalence of overweight and obesity was 63% and 12%, respectively, in the Aydin et al study published in 2019, while the percentage was 19% and 2% in the study by Ruth et al published in 2005.…”

Section: Obesity and Overweightmentioning

confidence: 99%

“…In the long‐term cohorts, 19%‐35% of patients were overweight, with a body mass index (BMI) of ≥25 to 30 kg/m 2 and 2%‐17% were obese (BMI ≥ 30 kg/m 2 or >97 percentile) . Skrzypczyk et al compared their figures (23% overweight and 5% obese) with data for the general Polish population and found similar proportions, as overweight and obesity affected 24% aged 18‐39 years.…”

Section: Obesity and Overweightmentioning

confidence: 99%

“…Nephrotic syndrome (NS) is the most common glomerular disease in childhood and one of the major aetiologies that contributes to childhood exposure to systemic glucocorticoids. The annual incidence of NS is estimated to be 2‐7 per 100 000 children …”

Section: Introductionmentioning

confidence: 99%

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Review on long‐term non‐renal complications of childhood nephrotic syndrome

et al. 2019

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Background Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long‐term renal prognosis of childhood‐onset idiopathic NS. However, the nonrenal outcomes have not been studied as much. Aim We aimed to discuss the long‐term non‐renal outcomes of childhood NS, highlighting studies with a follow‐up period of more than 10 years. Results We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non‐renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non‐renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies. Conclusion This review discusses and summarises the non‐renal outcomes of idiopathic childhood NS.

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Section: Growth and Heightmentioning

confidence: 70%