The long‐term outcome of extremely preterm (&lt;28 weeks’ gestational age) infants with and without severe retinopathy of prematurity

Molloy, Carly; Anderson, Peter J.; Anderson, Vicki; Doyle, Lex W.

doi:10.1111/jnp.12069

Cited by 40 publications

(39 citation statements)

References 101 publications

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“…Developing chronic lung disease is another common condition in preterm infants, which can also impact on neurodevelopment (23). Neurodevelopment dysfunction is also increased in preterm infants who require surgery for necrotizing enterocolitis (24), who are exposed to sepsis (25), or suffer from severe retinopathy of prematurity (26). The clinical course scores were collected at discharge, following diagnosis of any of these major complications, therefore more information, comparative to the early physiological analysis, was available to accurately predict outcome.…”

Section: Discussionmentioning

confidence: 99%

Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring

et al. 2016

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Background: Preterm infants are at risk of adverse outcome. The aim of this study is to develop a multimodal model, including physiological signals from the first days of life, to predict 2-y outcome in preterm infants. Methods: Infants <32 wk gestation had simultaneous multichannel electroencephalography (EEG), peripheral oxygen saturation (SpO 2 ), and heart rate (HR) monitoring. EEG grades were combined with gestational age (GA) and quantitative features of HR and SpO 2 in a logistic regression model to predict outcome. Bayley Scales of Infant Development-III assessed 2-y neurodevelopmental outcome. A clinical course score, grading infants at discharge as high or low morbidity risk, was used to compare performance with the model. results: Forty-three infants were included: 27 had good outcomes, 16 had poor outcomes or died. While performance of the model was similar to the clinical course score graded at discharge, with an area under the receiver operator characteristic (AUC) of 0.83 (95% confidence intervals (CI): 0.69-0.95) vs. 0.79 (0.66-0.90) (P = 0.633), the model was able to predict 2-y outcome days after birth. conclusion: Quantitative analysis of physiological signals, combined with GA and graded EEG, shows potential for predicting mortality or delayed neurodevelopment at 2 y of age.

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Section: Discussionmentioning

confidence: 99%

Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring

et al. 2016

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“…Ex-preterm infants also have abnormal higher visual processing that result in difficulties with visual scenes (for example, finding a toy against a patterned background), visual guidance (for example, walking over uneven ground) and recognition and orientation, all manifestations of cerebral visual impairment (Dutton, 2009, Ortibus et al, 2011 A recent study suggests that much of the demonstrable association between severe ROP and NND is the result of common shared risk factors. In a cohort of 17-18 year old former extremely low birth weight (ELBW: birth weight <1000g) infants from Victoria, Australia, Molloy and colleagues (Molloy et al, 2015) found those with a history of severe ROP had poorer test performance including on visual processing and visual-motor integration as well as reading, arithmetic and IQ compared with those without severe ROP. They also reported that after controlling for neonatal factors (severe WMI, postnatal corticosteroids and neonatal surgery) the differences between the groups diminished with only poorer visual acuity remaining significant.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Pathophysiology, screening and treatment of ROP: A multi-disciplinary perspective

Chan‐Ling

Gole

Quinn

et al. 2018

Progress in Retinal and Eye Research

129

107

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The population of infants at risk for retinopathy of prematurity (ROP) varies by world region; in countries with well developed neonatal intensive care services, the highest risk infants are those born at less than 28 weeks gestational age (GA) and less than 1 kg at birth, while, in regions where many aspects of neonatal intensive and ophthalmological care are not routinely available, more mature infants up to 2000 g at birth and 37 weeks GA are also at risk for severe ROP. Treatment options for both groups of patients include standard retinal laser photocoagulation or, more recently, intravitreal anti-VEGF drugs. In addition to detection and treatment of ROP, this review highlights new opportunities created by telemedicine, where screening and diagnosis of ROP in remote locations can be undertaken by non-ophthalmologists using digital fundus cameras. The ophthalmological care of the ROP infant is undertaken in the wider context of neonatal care and general wellbeing of the infant. Because of this context, this review takes a multi-disciplinary perspective with contributions from retinal vascular biologists, pediatric ophthalmologists, an epidemiologist and a neonatologist. This review highlights the latest insights regarding cellular and molecular mechanisms in the formation of the retinal vasculature in the human infant, pathogenesis of ROP, detection and treatment of severe ROP, the risks and benefits of anti-VEGF therapy, the identification of new therapies over the horizon, and the optimal neonatal care regimen for best ROP outcomes, and the benefits and pitfalls of telemedicine in the remote screening and diagnosis of ROP, all of which have the potential to improve ROP outcomes.

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“…Molloy et al (2015) reported that infants with severe ROP are at increased risk of poor cognitive outcome compared to very low birthweight preterm infants without eye lesions (ROP). Molloy et al (2015) reported that infants with severe ROP are at increased risk of poor cognitive outcome compared to very low birthweight preterm infants without eye lesions (ROP).…”

Section: Comparison Of Neurological Outcome To Other Collectivesmentioning

confidence: 99%

“…In this study, the most preterm children with poor neurologic outcome defined by the Bayleys scores were observed in the group of children with ROP. Molloy et al (2015) reported that infants with severe ROP are at increased risk of poor cognitive outcome compared to very low birthweight preterm infants without eye lesions (ROP). The mechanism responsible is complex and probably caused by ROP and possible accompanying processes.…”

Section: Comparison Of Neurological Outcome To Other Collectivesmentioning

confidence: 99%

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Fieß

Kölb-Keerl

Schuster³

et al. 2018

Acta Ophthalmologica

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The long‐term outcome of extremely preterm (<28 weeks’ gestational age) infants with and without severe retinopathy of prematurity

Abstract: Extremely preterm children with severe ROP are at increased risk for ongoing visual processing difficulties and lower IQ compared with EP peers without severe ROP. While severe ROP is a predictor of long-term impairments, this association is largely mediated by other neonatal risk factors.

Cited by 40 publications

References 101 publications

Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring

Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring

Pathophysiology, screening and treatment of ROP: A multi-disciplinary perspective

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

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